Results 21 to 30 of about 94,143 (143)

Protein post-translational modification by lysine succinylation: Biochemistry, biological implications, and therapeutic opportunities [PDF]

Genes and Diseases, 2023
Longxiang Xie, Jinshuai Guo, Jianping Xie   +2 more
exaly   +2 more sources

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction [PDF]

Advanced science
Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Meng N, Zhou J, Guo X, Hong T, Li X, Wei X, Zhang C, Zhang X, Liu S, Zhang Y, Yao L, Huang L, Gu W.   +12 more
europepmc   +2 more sources

Biochemical Analysis of Histone Succinylation [PDF]

Biochemistry Research International, 2017
Posttranslational modification (PTM) of proteins is used to regulate protein activity and stability. Histone PTMs are regarded as some of the most important, as they can directly regulate gene expression through chromatin reorganization.
Atsushi Yokoyama, Shogo Katsura, Akira Sugawara   +2 more
doaj   +2 more sources

Regulation of urea cycle by reversible high-stoichiometry lysine succinylation. [PDF]

Nat Metab
The post-translational modification lysine succinylation is implicated in the regulation of various metabolic pathways. However, its biological relevance remains uncertain due to methodological difficulties in determining high-impact succinylation sites.
Zhang R, Fang J, Xie X, Carrico C, Meyer JG, Wei L, Bons J, Rose J, Riley R, Kwok R, Ashok Kumaar PV, Zhang Y, Bielska O, He W, Nishida Y, Liu X, Locasale JW, Schilling B, Verdin E.   +18 more
europepmc   +2 more sources

Stage‐Specific H3K14 and H3K23 Succinylation Orchestrates Insect Metamorphosis and Oogenesis [PDF]

Advanced Science
Histone lysine succinylation is a pivotal epigenetic modification for diverse biological processes, yet how it regulates insect metamorphosis and reproduction remains poorly understood.
Yu‐Pu Jing, Lunjie Li, Libin Yang, Lin‐Jie Zhang, Qiang Yan, Ci Zhang, Zanrong Wen, Guangze Yu, Qian Li, Shutang Zhou   +9 more
doaj   +2 more sources

Lysine succinylation and SIRT5 couple nutritional status to glutamine catabolism. [PDF]

Mol Cell Oncol, 2020
The metabolic microenvironment of tumors is characterized by fluctuating and limited nutrient availability. To survive these conditions, cancer cell-intrinsic mechanisms sense and signal nutritional status.
Lukey MJ, Greene KS, Cerione RA.
europepmc   +2 more sources

Tandem mass tag-based quantitative proteomic analysis identification of succinylation related proteins in pathogenesis of thoracic aortic aneurysm and aortic dissection [PDF]

PeerJ, 2023
Background Thoracic aortic aneurysm and dissection (TAAD) are devastating cardiovascular diseases with a high rate of disability and mortality. Lysine succinylation, a newly found post-translational modification, has been reported to play an important ...
Yu Zhang, Hongwei Zhang, Haiyue Wang, Chenhao Wang, Peng Yang, Chen Lu, Yu Liu, Zhenyuan Xu, Yi Xie, Jia Hu   +9 more
doaj   +2 more sources

Lysine Succinylation Contributes to Aflatoxin Production and Pathogenicity in Aspergillus flavus. [PDF]

Mol Cell Proteomics, 2018
Aspergillus flavus (A. flavus) is a ubiquitous saprophytic and pathogenic fungus that produces the aflatoxin carcinogen, and A. flavus can have tremendous economic and health impacts worldwide.
Ren S, Yang M, Yue Y, Ge F, Li Y, Guo X, Zhang J, Zhang F, Nie X, Wang S.   +9 more
europepmc   +2 more sources

Global Proteomic Analysis of Lysine Succinylation in Zebrafish (Danio rerio)

, 2019
Lysine succinylation (Ksu) is a novel identified post-translational modification that is conserved from prokaryotes to eukaryotes. As a kind of acylation, Ksu was reported to have different functions than other acylations at lysine residues.
Yan Gao (93649), Oh Kwang Kwon (1471246), Sangkyu Lee (228641), Minjia Tan (629800), Ki-Tae Kim (1847161), Hyojin Lee (182880)   +5 more
core   +6 more sources

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source