Results 21 to 30 of about 3,037 (136)

Global analysis of lysine succinylation in patchouli plant leaves. [PDF]

Hortic Res, 2019
AbstractLysine succinylation is a novel, naturally occurring posttranslational modification (PTM) in living organisms. Global lysine succinylation identification has been performed at the proteomic level in various species; however, the study of lysine succinylation in plant species is relatively limited. Patchouli plant (P.
Wang X, Chen X, Li J, Zhou X, Liu Y, Zhong L, Tang Y, Zheng H, Liu J, Zhan R, Chen L.   +10 more
europepmc   +3 more sources

First analyses of lysine succinylation proteome and overlap between succinylation and acetylation in Solenopsis invicta Buren (Hymenoptera: Formicidae). [PDF]

BMC Genomics, 2022
Abstract Background Lysine succinylation (Ksu) exists in both eukaryotes and prokaryotes, and influences a variety of metabolism processes. However, little attention has been paid to Ksu in insects, especially the notorious invasive pest Solenopsis ...
Ye J, Li J.
europepmc   +5 more sources

Tandem mass tag-based quantitative proteomic analysis identification of succinylation related proteins in pathogenesis of thoracic aortic aneurysm and aortic dissection [PDF]

PeerJ, 2023
Background Thoracic aortic aneurysm and dissection (TAAD) are devastating cardiovascular diseases with a high rate of disability and mortality. Lysine succinylation, a newly found post-translational modification, has been reported to play an important ...
Yu Zhang, Hongwei Zhang, Haiyue Wang, Chenhao Wang, Peng Yang, Chen Lu, Yu Liu, Zhenyuan Xu, Yi Xie, Jia Hu   +9 more
doaj   +2 more sources

Succinylated lysine residue prediction revisited

Briefings in Bioinformatics, 2022
AbstractMotivationLysine succinylation is a kind of post-translational modification (PTM) which plays a crucial role in regulating the cellular processes. Aberrant succinylation may cause inflammation, cancers, metabolism diseases and nervous system diseases. The experimental methods to detect succinylation sites are time-consuming and costly.
Shehab Sarar Ahmed, Zaara Tasnim Rifat, Mohammad Saifur Rahman, M. Sohel Rahman   +3 more
openaire   +2 more sources

Global profiling of lysine succinylation in human lungs

PROTEOMICS, 2022
AbstractThe lysine succinylation (Ksucc) is involved in many core energy metabolism pathways and affects the metabolic process in mitochondria, making this modification highly valuable for studying diseases related to mitochondrial disorders. In this paper, we used liquid chromatography with tandem mass spectrometry (LC‐MS/MS) to perform the first ...
Ye‐Hong Yang, Song‐Feng Wu, Yun‐Ping Zhu, Jun‐Tao Yang, Jiang‐Feng Liu   +4 more
openaire   +2 more sources

Proteome-Wide Identification of Lysine Succinylation in the Proteins of Tomato (Solanum lycopersicum). [PDF]

PLoS ONE, 2016
Post-translational modification of proteins through lysine succinylation plays important regulatory roles in living cells. Lysine succinylation was recently identified as a novel post-translational modification in Escherichia coli, yeast, Toxoplasma ...
Weibo Jin, Fangli Wu
doaj   +1 more source

Regulation of urea cycle by reversible high-stoichiometry lysine succinylation. [PDF]

Nat Metab
The post-translational modification lysine succinylation is implicated in the regulation of various metabolic pathways. However, its biological relevance remains uncertain due to methodological difficulties in determining high-impact succinylation sites.
Zhang R, Fang J, Xie X, Carrico C, Meyer JG, Wei L, Bons J, Rose J, Riley R, Kwok R, Ashok Kumaar PV, Zhang Y, He W, Nishida Y, Liu X, Locasale JW, Schilling B, Verdin E.   +17 more
europepmc   +3 more sources

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Global Proteomic Analysis Reveals Widespread Lysine Succinylation in Rice Seedlings. [PDF]

Int J Mol Sci, 2019
Lysine succinylation (Ksu) is a dynamic and reversible post-translational modification that plays an important role in many biological processes. Although recent research has analyzed Ksu plant proteomes, little is known about the scope and cellular distribution of Ksu in rice seedlings.
Zhang K, Xiong Y, Sun W, Wang GL, Liu W.
europepmc   +4 more sources

Succinylation of a KEAP1 sensor lysine promotes NRF2 activation

Cell Chemical Biology, 2023
SummaryCrosstalk between metabolism and stress-responsive signaling is essential to maintaining cellular homeostasis. One way this crosstalk is achieved is through the covalent modification of proteins by endogenous, reactive metabolites that regulate the activity of key stress-responsive transcription factors such as NRF2.
Lara Ibrahim, Caroline Stanton, Kayla Nutsch, Thu Nguyen, Chloris Li-Ma, Yeonjin Ko, Gabriel C. Lander, R. Luke Wiseman, Michael J. Bollong   +8 more
openaire   +3 more sources