Results 1 to 10 of about 47,686 (230)

Lysophosphatidic acid 2 alleviates deep vein thrombosis via protective endothelial barrier function [PDF]

Open Medicine
The specific role of lysophosphatidic acid 2 (LPA2) in deep vein thrombosis (DVT) remains unclear.
Bai Ruifeng, Yue Xinyang, Tian Xuan, Zhao Huiru, Liu Ying, Li Tian, Wu Jun   +6 more
doaj   +2 more sources

Lysophosphatidic Acid Signaling in the Gastrointestinal SystemSummary [PDF]

Cellular and Molecular Gastroenterology and Hepatology
The intestinal epithelium undergoes continuous homeostatic renewal to conduct the digestion and absorption of nutrients. At the same time, the intestinal epithelial barrier separates the host from the intestinal lumen, preventing systemic infection from ...
C. Chris Yun, Yiran Han, Beth McConnell
doaj   +2 more sources

The effect of lysophosphatidic acid on myometrial contractility and the mRNA transcription of its receptors in the myometrium at different stages of endometrosis in mares [PDF]

BMC Veterinary Research
Background Endometrosis (chronic degenerative endometritis) results in morphological changes in the equine endometrium and impairs its secretory function. However, the effect of this condition on the myometrium remains unclear. Lysophosphatidic acid (LPA)
Katarzyna Karolina Piotrowska-Tomala, Anna Szóstek-Mioduchowska, Agnieszka Walentyna Jonczyk, Ewa Monika Drzewiecka, Michał Hubert Wrobel, Takuo Hojo, Graca Ferreira-Dias, Dariusz Jan Skarzynski   +7 more
doaj   +2 more sources

Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment. [PDF]

, 2013
Lysophosphatidic acid (LPA) is a pleiotropic phospholipid present in the blood and certain tissues at high concentrations; its diverse effects are mediated through differential, tissue specific expression of LPA receptors.
Cardinal, Sofie, Chan, Rebecca, Corselli, Mirko, Crooks, Gay M, Dunn, Bruce, Evseenko, Denis, Latour, Brooke, Richardson, Wade, Sahaghian, Arineh, Zhu, Yuhua   +9 more
core   +11 more sources

A novel highly potent autotaxin/ENPP2 inhibitor produces prolonged decreases in plasma lysophosphatidic acid formation in vivo and regulates urethral tension. [PDF]

PLoS ONE, 2014
Autotaxin, also known as ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2), is a secreted enzyme that has lysophospholipase D activity, which converts lysophosphatidylcholine to bioactive lysophosphatidic acid. Lysophosphatidic acid activates at
Hiroshi Saga, Akira Ohhata, Akio Hayashi, Makoto Katoh, Tatsuo Maeda, Hirotaka Mizuno, Yuka Takada, Yuka Komichi, Hiroto Ota, Naoya Matsumura, Masami Shibaya, Tetsuya Sugiyama, Shinji Nakade, Katsuya Kishikawa   +13 more
doaj   +1 more source

Lysophosphatidic Acid Signaling and microRNAs: New Roles in Various Cancers

Frontiers in Oncology, 2022
A wide range of microRNAs (miRNAs) are coded for in the human genome and contribute to the regulation of gene expression. MiRNAs are able to degrade mRNAs and/or prevent the RNA transcript from being translated through complementary binding of the miRNA ...
Mahdi Rafiyan, Mahdi Rafiyan, Mohammad Hassan Jafari Najaf Abadi, Seyed Saeed Tamehri Zadeh, Michael R. Hamblin, Mahboubeh Mousavi, Hamed Mirzaei   +6 more
doaj   +1 more source

The contribution of lysophosphatidic acid receptors in the response of human lower esophageal sphincter under the electrical field stimulation

BMC Gastroenterology, 2023
Background This study aims to identify the impact on the reaction while the clasp and sling fibers of the human lower esophageal sphincter are under the electrical field stimulation, by adding lysophosphatidic acid receptor subtypes antagonist.
Yong Feng, Wei Wei, Liang Chen, Jun-Feng Liu   +3 more
doaj   +1 more source

2-Carba-lysophosphatidic acid is a novel β-lysophosphatidic acid analogue with high potential for lysophosphatidic acid receptor activation and autotaxin inhibition

Scientific Reports, 2021
Cyclic phosphatidic acid (cPA) is a naturally occurring phospholipid mediator that, along with its chemically stabilized analogue 2-carba-cyclic phosphatidic acid (2ccPA), induces various biological activities in vitro and in vivo.
Keiko Fukasawa, Mari Gotoh, Akiharu Uwamizu, Takatsugu Hirokawa, Masaki Ishikawa, Yoshibumi Shimizu, Shinji Yamamoto, Kensuke Iwasa, Keisuke Yoshikawa, Junken Aoki, Kimiko Murakami-Murofushi   +10 more
doaj   +1 more source

Lysophosphatidic Acid Mediates Activating Transcription Factor 3 Expression Which Is a Target for Post-Transcriptional Silencing by miR-30c-2-3p. [PDF]

PLoS ONE, 2015
Although microRNAs (miRNAs) are small, non-protein-coding entities, they have important roles in post-transcriptional regulation of most of the human genome.
Ha T Nguyen, Wei Jia, Aaron M Beedle, Eileen J Kennedy, Mandi M Murph   +4 more
doaj   +1 more source

The effect of lysophosphatidic acid-supplemented culture medium on human immature oocytes matured in vitro

Reproductive Biology and Endocrinology, 2021
Background Lysophosphatidic acid-supplemented culture medium significantly increases the oocyte maturation rate in vitro. However, potential targets and pathways involved remain unknown.
Qigui Xie, Yaxin Xing, Jianhong Zhou, Ling Wang, Jie Wu, Ri-Cheng Chian   +5 more
doaj   +1 more source