Results 91 to 100 of about 24,193 (235)

Novel lysophosphoplipid receptors: their structure and function

Journal of Lipid Research, 2014
It is now accepted that lysophospholipids (LysoGPs) have a wide variety of functions as lipid mediators that are exerted through G protein-coupled receptors (GPCRs) specific to each lysophospholipid.
Kumiko Makide, Akiharu Uwamizu, Yuji Shinjo, Jun Ishiguro, Michiyo Okutani, Asuka Inoue, Junken Aoki   +6 more
doaj   +1 more source

Docosatetraenoyl LPA is elevated in exhaled breath condensate in idiopathic pulmonary fibrosis [PDF]

, 2014
Background: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease with no effective medical therapies. Recent research has focused on identifying the biological processes essential to the development and progression of fibrosis, and on ...
Berdyshev, Evgeny V, Brenner, Laura N, Gorshkova, Irina A, Mathai, Susan K, Montesi, Sydney B, Shea, Barry S, Tager, Andrew M   +6 more
core   +2 more sources

Lysophosphatidic Acid Receptor LPAR6 Supports the Tumorigenicity of Hepatocellular Carcinoma [PDF]

Cancer Research, 2015
Abstract The aberrant processes driving hepatocellular carcinoma (HCC) are not fully understood. Lysophosphatidic acid receptors (LPAR) are commonly overexpressed in HCC, but their contributions to malignant development are not well established.
MAZZOCCA, ANTONIO, DITURI, FRANCESCO, De Santis, Flavia, Filannino, Addolorata, Lopane, Chiara, Betz, Regina C., Li, Ying Yi, Mukaida, Naofumi, Winter, Peter, TORTORELLA, Cosimo, GIANNELLI, Gianluigi, SABBA', Carlo   +11 more
openaire   +4 more sources

Placenta‐derived extracellular vesicles: Signal messengers shuttling across the maternal‐fetal barrier

Interdisciplinary Medicine, EarlyView.
In normal pregnancy, PEVs help maintain maternal–fetal immune tolerance while enabling controlled immune activation, promote endothelial migration, and support trophoblast invasion and syncytialization, strengthening antimicrobial defense. In pregnancy‐related disorders, dysregulated PEV signaling may drive endothelial dysfunction and hypertension, BBB
Jiale Du, Maliang Tao, Yanxuan Xiao, Zhijian Wang, Bo Situ, Lei Zheng   +5 more
wiley   +1 more source

Aberrant lipid metabolism: an emerging diagnostic and therapeutic target in ovarian cancer [PDF]

, 2013
Ovarian cancer remains the most lethal gynaecological cancer. A better understanding of the molecular pathogenesis of ovarian cancer is of critical importance to develop early detection tests and identify new therapeutic targets that would increase ...
Agarwal, Anliker, Aoki, Baker, Bensaad, Cai, Carmela Ricciardelli, Carmen Pyragius, Chae, Chajes, Chang, Choi, Daly, Dong, Eck, Eder, Fishman, Gansler, Gatt, Hanada, Hu, Hu, Illuzzi, Imamura, Iwasawa, Jeong, Jiang, Kimura, Kushi, La Vecchia, Lee, Lee, Li, Little, Makhlouf, Maria Fuller, Martin Oehler, Menendez, Migita, Mukherjee, Murthi, Nakamura, Nam, Nam, Nieman, Noguchi, Pan, Pewzner-Jung, Pizer, Ptaszynska, Pustilnik, Radin, Rahman, Ren, Risch, Risch, Ryland, Sawada, Selzner, Shida, Shintani, Siegel, Song, Spiegel, Sutphen, Swanton, Swinnen, Swinnen, Tania, Tokumura, Tomek, Ueda, Umezu-Goto, Van Vlerken, Vidot, Von Haefen, Wang, Watanabe, Xiao, Xu, Xu, Yanagida, Yang, Yu, Zhang, Zhou, Zhou   +86 more
core   +3 more sources

Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu, Xingju Zou, Yang Zheng, Chen Sun, Cheng Peng   +4 more
wiley   +1 more source

LPA receptor signaling: pharmacology, physiology, and pathophysiology

Journal of Lipid Research, 2014
Lysophosphatidic acid (LPA) is a small ubiquitous lipid found in vertebrate and nonvertebrate organisms that mediates diverse biological actions and demonstrates medicinal relevance. LPA's functional roles are driven by extracellular signaling through at
Yun C. Yung, Nicole C. Stoddard, Jerold Chun   +2 more
doaj   +1 more source

Lysophosphatidic Acid Promotes Epithelial to Mesenchymal Transition in Ovarian Cancer Cells by Repressing SIRT1 [PDF]

, 2017
Epithelial-to-mesenchymal transition (EMT) plays an essential role in the transition from early to invasive phenotype, however the underlying mechanisms still remain elusive.
Ray, Upasana, Roy Chowdhury, Shreya, Roy, Sib Sankar   +2 more
core   +2 more sources

Beyond the chaos: How architecture structures tumour biology

The FEBS Journal, EarlyView.
Tissue architecture shapes tumour initiation and progression through multiple interconnected layers continuously remodelled over time. This review outlines how physical forces, biochemical cues, cellular niches and systemic influences contribute to tumour evolution.
Lea Dörner, Catrin Lutz, Stefan Prekovic, Hendrik A. Messal   +3 more
wiley   +1 more source

Inhibition of lysophosphatidic acid receptor 1–3 deteriorates experimental autoimmune encephalomyelitis by inducing oxidative stress

Journal of Neuroinflammation, 2021
Background Lysophosphatidic acid receptors (LPARs) are G-protein-coupled receptors involved in many physiological functions in the central nervous system. However, the role of the LPARs in multiple sclerosis (MS) has not been clearly defined yet. Methods
Jong Hee Choi, Jinhee Oh, Min Jung Lee, Hyunsu Bae, Seong-Gyu Ko, Seung-Yeol Nah, Ik-Hyun Cho   +6 more
doaj   +1 more source