Results 51 to 60 of about 7,531 (229)

Action mechanism of hypoglycemic principle 9-(R)-HODE isolated from cortex lycii based on a metabolomics approach

Frontiers in Pharmacology, 2022
The 9-(R)-HODE is an active compound isolated from cortex lycii that showed significant hypoglycemic effects in our previous in vitro study. In this study, 9-(R)-HODE’s in vivo hypoglycemic activity and effect on alleviating diabetic complications ...
Yueqiu Liu, Yueqiu Liu, Xinyi Hu, Wen Zheng, Lu Zhang, Luolan Gui, Ge Liang, Yong Zhang, Liqiang Hu, Xin Li, Yi Zhong, Tao Su, Xin Liu, Jingqiu Cheng, Meng Gong   +14 more
doaj   +1 more source

Hepatocellular carcinoma: Review of disease and tumor biomarkers. [PDF]

, 2016
© The Author(s) 2016.Hepatocellular carcinoma (HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative
Cox, IJ, Crossey, MM, Fye, HK, Gomez-Romero, M, Holmes, E, Kim, JU, Njie, R, Shariff, MI, Taylor-Robinson, SD   +8 more
core   +1 more source

Plasma lipid profiling for the prognosis of 90-day mortality, in-hospital mortality, ICU admission, and severity in bacterial community-acquired pneumonia (CAP)

Critical Care, 2020
Introduction Pneumonia is the most common cause of mortality from infectious diseases, the second leading cause of nosocomial infection, and the leading cause of mortality among hospitalized adults.
Mohammad M. Banoei, Hans J. Vogel, Aalim M. Weljie, Sachin Yende, Derek C. Angus, Brent W. Winston   +5 more
doaj   +1 more source

Metabolic profiling reveals interleukin-17A monoclonal antibody treatment ameliorate lipids metabolism with the potentiality to reduce cardiovascular risk in psoriasis patients

Lipids in Health and Disease, 2021
Background Psoriasis is a common chronic inflammatory skin disease associated with overproduction of interleukin-17A (IL-17A). IL-17A monoclonal antibodies (mAbs) have shown clinical efficacy in psoriasis patients.
Han Cao, Shengmin Su, Qi Yang, Yunchen Le, Lihong Chen, Mengyan Hu, Xiaoyu Guo, Jie Zheng, Xia Li, Yunqiu Yu   +9 more
doaj   +1 more source

Dysregulated Choline, Methionine, and Aromatic Amino Acid Metabolism in Patients with Wilson Disease: Exploratory Metabolomic Profiling and Implications for Hepatic and Neurologic Phenotypes. [PDF]

, 2019
Wilson disease (WD) is a genetic copper overload condition characterized by hepatic and neuropsychiatric symptoms with a not well-understood pathogenesis.
Czlonkowska, Anna, Kim, Kyoungmi, Litwin, Tomasz, Mazi, Tagreed A, Medici, Valentina, Sarode, Gaurav V, Shibata, Noreene M   +6 more
core   +2 more sources

Quantification and Localisation of New Brain Lipid Synthesis Using Deuterium Oxide and High Resolution Mass Spectrometry

Angewandte Chemie, EarlyView.
Liquid chromatography tandem mass spectrometry and mass spectrometry imaging were used in combination with deuterium oxide administration to quantify and localise newly synthesised myelin lipids in the mouse brain. This methodology, used here to show sites of myelin repair, enables the measurement of dynamic lipid synthesis in living systems and ...
Catherine Zhang, Jesse A. Michael, Jonathan D. Teo, Huitong Song, Mika T. Westerhausen, Shadrack M. Mutuku, Shane R. Ellis, Anthony S. Don   +7 more
wiley   +2 more sources

Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance [PDF]

, 2017
Although chemotherapy is designed to eradicate tumor cells, it also has significant effects on normal tissues. The platinum-induced fatty acid 16:4(n-3) (hexadeca-4,7,10,13-tetraenoic acid) induces systemic resistance to a broad range of DNA-damaging ...
Daenen, Laura G.M., Hansen, Steffen V.F., Hirasawa, Akira, Houthuijzen, Julia M., Hudson, Brian D., Ishihara, Kenji, Jaarsveld, Marijn T.M., McLean, Chelsea M., Milligan, Graeme, Oosterom, Ilse, Peeper, Daniel S., Roodhart, Jeanine M.L., Sadatmand, Sahar Jafari, Ulven, Trond, van de Lest, Chris H.A., Voest, Emile E.   +15 more
core   +12 more sources

Acacetin Attenuates Lysophosphatidylcholine-Induced Vascular Smooth Muscle Cell Injury via Sirt1-Nrf2/p62 Signaling Axis

Biomedicines
Background: Acacetin, a naturally occurring flavone present in various plants, is known as a promising drug candidate for cardiovascular disorders.
Yun-Da Li, Yao Wu, Tian-Li Zhou, Qian Yuan, Gui-Rong Li, Wei-Yin Wu, Yan Wang, Gang Li   +7 more
doaj   +1 more source

Metabolic characterization of the natural progression of chronic hepatitis B [PDF]

, 2016
Background: Worldwide, over 350 million people are chronically infected with the hepatitis B virus (HBV) and are at increased risk of developing progressive liver diseases.
Berger, R. (Ruud), Boonstra, P.A. (André), Hankemeier, T. (Thomas), Harms, A.C. (Amy), Hou, J. (Jun), Schoeman, J.C. (Johannes C.), Vreeken, R. (Rob)   +6 more
core   +1 more source

Gut opportunistic pathogens contribute to high-altitude pulmonary edema by elevating lysophosphatidylcholines and inducing inflammation

Microbiology Spectrum
Gut microbiota have been found to promote hypoxia-induced intestinal injury. However, the role of gut microbiota in high-altitude pulmonary edema (HAPE), the preventive effect of synbiotic on HAPE, and the mechanisms by which they might work remain ...
Xianduo Sun, Gaosheng Hu, Yuting Li, Wenjing Li, Yong Wang, Hui Yan, Guoqing Long, Long Zhao, Anhua Wang, Jingming Jia   +9 more
doaj   +1 more source