Results 61 to 70 of about 10,942 (204)

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li   +12 more
wiley   +1 more source

A starch edible surface coating delays banana fruit ripening [PDF]

open access: yes, 2019
A rice starch edible coating blended with sucrose esters was developed for controlling the postharvest physiological activity of Cavendish banana to extend postharvest quality during ripening at 20 ± 2 °C.
Bowyer, Michael   +6 more
core   +2 more sources

Identification and Validation of Biomarkers in Chronic Rhinosinusitis With Nasal Polyps and Study of Their Associated Mechanisms

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Cell senescence (CS) and lipid metabolism (LM) disorders have been reported in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the mechanism is still unclear. Methods Data were obtained from public databases; differential expression analysis and machine learning were performed to identify biomarkers and to understand the
Hui‐Yi Deng   +3 more
wiley   +1 more source

Elevated Serum Levels of Arachidonoyl-lysophosphatidic Acid and Sphingosine 1-Phosphate in Systemic Sclerosis

open access: yesInternational Journal of Medical Sciences, 2009
Systemic sclerosis (SSc) is an often fatal disease characterized by autoimmunity and inflammation, leading to widespread vasculopathy and fibrosis.
Akira Tokumura, Laura D. Carbone, Yasuko Yoshioka, Junichi Morishige, Masaki Kikuchi, Arnold Postlethwaite, Mitchell A. Watsky
doaj  

Surface loops of extracellular phospholipase A1 determine both substrate specificity and preference for lysophospholipids

open access: yesJournal of Lipid Research, 2012
Members of the pancreatic lipase family exhibit both lipase activity toward triacylglycerol and/or phospholipase A1 (PLA1) activity toward certain phospholipids.
Naoaki Arima   +4 more
doaj   +1 more source

Lysophospholipids Facilitate COPII Vesicle Formation [PDF]

open access: yesCurrent Biology, 2018
Coat protein complex II (COPII) proteins form vesicles from the endoplasmic reticulum to export cargo molecules to the Golgi apparatus. Among the many proteins involved in this process, Sec12 is a key regulator, functioning as the guanosine diphosphate (GDP) exchange factor for Sar1p, the small guanosine triphosphatase (GTPase) that initiates COPII ...
Melero Carrillo, Alejandro   +7 more
openaire   +3 more sources

Circulating Rhythmic Metabolites and Causal Risk of Type 2 Diabetes in Adults in the Canadian Longitudinal Study on Aging

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Circadian regulation of metabolism is an important factor in metabolic health, yet the role of rhythmic metabolites in Type 2 diabetes development remains poorly understood. This study investigated associations between circulating rhythmic metabolites and incident Type 2 diabetes risk and evaluated causal relationships using two‐sample ...
Divya Joshi   +10 more
wiley   +1 more source

Characterization and relative quantification of phospholipids based on methylation and stable isotopic labeling[S]

open access: yesJournal of Lipid Research, 2016
Phospholipids (PLs), one of the lipid categories, are not only the primary building blocks of cellular membranes, but also can be split to produce products that function as second messengers in signal transduction and play a pivotal role in numerous ...
Tanxi Cai   +12 more
doaj   +1 more source

Opposing roles of DGAT‐mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity

open access: yesThe FEBS Journal, EarlyView.
Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump   +10 more
wiley   +1 more source

Novel bisretinoids of human retina are lyso alkyl ether glycerophosphoethanolamine-bearing A2PE species

open access: yesJournal of Lipid Research, 2018
Bisretinoids are a family of fluorophores that form in photoreceptor cells' outer segments by nonenzymatic reaction of two vitamin A aldehydes (A2) with phosphatidylethanolamine (PE).
Hye Jin Kim, Janet R. Sparrow
doaj   +1 more source

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