Results 41 to 50 of about 6,898 (217)

Upregulation of ABC transporters contributes to chemoresistance of sphingosine 1-phosphate lyase-deficient fibroblasts

Journal of Lipid Research, 2015
Sphingosine 1-phosphate (S1P) is an extra- and intracellular mediator that regulates cell growth, survival, migration, and adhesion in many cell types.
Katja Ihlefeld, Hans Vienken, Ralf Frederik Claas, Kira Blankenbach, Agnes Rudowski, Michael ter Braak, Alexander Koch, Paul P. Van Veldhoven, Josef Pfeilschifter, Dagmar Meyer zu Heringdorf   +9 more
doaj   +1 more source

Lysophospholipids in laboratory medicine

Proceedings of the Japan Academy, Series B, 2018
Lysophospholipids (LPLs), such as lysophosphatidic acid (LPA), sphingosine 1-phosphate (S1P), and lysophosphatidylserine (LysoPS), are attracting attention as second-generation lipid mediators. In our laboratory, the functional roles of these lipid mediators and the mechanisms by which the levels of these mediators are regulated in vivo have been ...
YATOMI, Yutaka, KURANO, Makoto, IKEDA, Hitoshi, IGARASHI, Koji, KANO, Kuniyuki, AOKI, Junken   +5 more
openaire   +3 more sources

Group 1B phospholipase A2 deficiency protects against diet-induced hyperlipidemia in mice

Journal of Lipid Research, 2011
Excessive absorption of products of dietary fat digestion leads to type 2 diabetes and other obesity-related disorders. Mice deficient in the group 1B phospholipase A2 (Pla2g1b), a gut digestive enzyme, are protected against diet-induced obesity and type
Norris I. Hollie, David Y. Hui
doaj   +1 more source

Functional Characterization of Lysophospholipids by Proteomic and Lipidomic Analysis of Fibroblast-like Synoviocytes

Cells, 2023
Synovial fluid (SF) from human knee joints with osteoarthritis (OA) has elevated levels of lysophosphatidylcholine (LPC) species, but their functional role is not well understood.
Thomas Timm, Christiane Hild, Gerhard Liebisch, Markus Rickert, Guenter Lochnit, Juergen Steinmeyer   +5 more
doaj   +1 more source

Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice

Journal of Lipid Research, 2019
HDL-bound ApoM and albumin are protein chaperones for the circulating bioactive lipid, sphingosine 1-phosphate (S1P); in this role, they support essential extracellular S1P signaling functions in the vascular and immune systems. We previously showed that
Hideru Obinata, Andrew Kuo, Yukata Wada, Steven Swendeman, Catherine H. Liu, Victoria A. Blaho, Rieko Nagumo, Kenichi Satoh, Takashi Izumi, Timothy Hla   +9 more
doaj   +1 more source

Lysophospholipid acyltransferases: Novel potential regulators of the inflammatory response and target for new drug discovery

, 2008
Molecular and biochemical analyses of membrane phospholipids have revealed that, in addition to their physico-chemical properties, the metabolites of phospholipids play a crucial role in the recognition, signalling and responses of cells to a variety of ...
Simon K. Jackson, Amanda J. Tonks, Jackson, Simon K., Abate, Wondwossen, Tonks, Amanda J., Wondwossen Abate   +5 more
core   +1 more source

Lysophospholipid (S1P) receptors in GtoPdb v.2023.1

, 2023
Sphingosine 1-phosphate (S1P) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Lysophospholipid receptors [96]) are activated by the endogenous lipid sphingosine 1-phosphate (S1P). Originally cloned as orphan members of the endothelial
Victoria Blaho, Blaho, Victoria, Jonnalagadda, Deepa, Deepa Jonnalagadda, Chun, Jerold, Jerold Chun, Kihara, Yasuyuki, Deron Herr, Herr, Deron, Yasuyuki Kihara, Jones, Danielle, Danielle Jones   +11 more
core   +1 more source

SnapShot: Bioactive Lysophospholipids

Cell, 2012
Lysophosphatidic acid (LPA; monoacyl-glycerol-3-phosphate) and sphingosine 1-phosphate (S1P) are bioactive lysophospholipids that regulate critical biological functions and disease processes. LPA and S1P act on distinct G protein-coupled receptors (GPCRs) that initiate multiple signaling cascades in many cell types.
Moolenaar, Wouter H., Hla, Timothy
openaire   +2 more sources

Lysophospholipid signaling: Beyond the EDGs [PDF]

Biochimica et Biophysica Acta (BBA) - General Subjects, 2008
As our understanding of the myriads of biological effects caused by lysophospholipids expands, we become witnesses to another miracle of nature that has endowed the simplest lysophospholipids with functions seemingly ubiquitous to every mammalian cell.
William J, Valentine, Yuko, Fujiwara, Ryoko, Tsukahara, Gabor, Tigyi   +3 more
openaire   +2 more sources

Updating Phospholipase A₂ Biology

Biomolecules, 2020
The phospholipase A2 (PLA2) superfamily contains more than 50 enzymes in mammals that are subdivided into several distinct families on a structural and biochemical basis.
Makoto Murakami, Hiroyasu Sato, Yoshitaka Taketomi   +2 more
doaj   +1 more source