Results 31 to 40 of about 7,391 (220)

Upregulation of ABC transporters contributes to chemoresistance of sphingosine 1-phosphate lyase-deficient fibroblasts

Journal of Lipid Research, 2015
Sphingosine 1-phosphate (S1P) is an extra- and intracellular mediator that regulates cell growth, survival, migration, and adhesion in many cell types.
Katja Ihlefeld, Hans Vienken, Ralf Frederik Claas, Kira Blankenbach, Agnes Rudowski, Michael ter Braak, Alexander Koch, Paul P. Van Veldhoven, Josef Pfeilschifter, Dagmar Meyer zu Heringdorf   +9 more
doaj   +1 more source

Lysophospholipids in laboratory medicine

Proceedings of the Japan Academy, Series B, 2018
Lysophospholipids (LPLs), such as lysophosphatidic acid (LPA), sphingosine 1-phosphate (S1P), and lysophosphatidylserine (LysoPS), are attracting attention as second-generation lipid mediators. In our laboratory, the functional roles of these lipid mediators and the mechanisms by which the levels of these mediators are regulated in vivo have been ...
YATOMI, Yutaka, KURANO, Makoto, IKEDA, Hitoshi, IGARASHI, Koji, KANO, Kuniyuki, AOKI, Junken   +5 more
openaire   +3 more sources

Group 1B phospholipase A2 deficiency protects against diet-induced hyperlipidemia in mice

Journal of Lipid Research, 2011
Excessive absorption of products of dietary fat digestion leads to type 2 diabetes and other obesity-related disorders. Mice deficient in the group 1B phospholipase A2 (Pla2g1b), a gut digestive enzyme, are protected against diet-induced obesity and type
Norris I. Hollie, David Y. Hui
doaj   +1 more source

Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice

Journal of Lipid Research, 2019
HDL-bound ApoM and albumin are protein chaperones for the circulating bioactive lipid, sphingosine 1-phosphate (S1P); in this role, they support essential extracellular S1P signaling functions in the vascular and immune systems. We previously showed that
Hideru Obinata, Andrew Kuo, Yukata Wada, Steven Swendeman, Catherine H. Liu, Victoria A. Blaho, Rieko Nagumo, Kenichi Satoh, Takashi Izumi, Timothy Hla   +9 more
doaj   +1 more source

Lysophospholipid acyltransferases: Novel potential regulators of the inflammatory response and target for new drug discovery

, 2008
Molecular and biochemical analyses of membrane phospholipids have revealed that, in addition to their physico-chemical properties, the metabolites of phospholipids play a crucial role in the recognition, signalling and responses of cells to a variety of ...
Simon K. Jackson, Amanda J. Tonks, Jackson, Simon K., Abate, Wondwossen, Tonks, Amanda J., Wondwossen Abate   +5 more
core   +1 more source

SnapShot: Bioactive Lysophospholipids

Cell, 2012
Lysophosphatidic acid (LPA; monoacyl-glycerol-3-phosphate) and sphingosine 1-phosphate (S1P) are bioactive lysophospholipids that regulate critical biological functions and disease processes. LPA and S1P act on distinct G protein-coupled receptors (GPCRs) that initiate multiple signaling cascades in many cell types.
Moolenaar, Wouter H., Hla, Timothy
openaire   +2 more sources

International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature

, 2002
The lysophospholipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), are now recognized as important extracellular signaling molecules. These lipid mediators are pleiotropic; among the most common cellular responses are mitogenesis, cell
Chun, Jerold, Goetzl, Edward J, Hla, Timothy, Moolenaar, Wouter, Pyne, Susan, Igarashi, Yasuyuki, Lynch, Kevin R, Tigyi, Gabor   +7 more
core   +3 more sources

Lysophospholipid interactions with protein targets

, 2008
Bioactive lysophospholipids include lysophosphatidic acid (LPA), sphingosine 1-phosphate (S1P), cyclic-phosphatidic acid (CPA) and alkyl glycerolphosphate (AGP).
Parrill, Abby L.
core   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source