Results 71 to 80 of about 10,942 (204)

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

open access: yesThe FEBS Journal, EarlyView.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo   +4 more
wiley   +1 more source

LPA receptor signaling: pharmacology, physiology, and pathophysiology

open access: yesJournal of Lipid Research, 2014
Lysophosphatidic acid (LPA) is a small ubiquitous lipid found in vertebrate and nonvertebrate organisms that mediates diverse biological actions and demonstrates medicinal relevance. LPA's functional roles are driven by extracellular signaling through at
Yun C. Yung   +2 more
doaj   +1 more source

Altered bactericidal activity aginst staphylococcus aureus in tuberculous bronchoalveolr lavage fluids [PDF]

open access: yes, 1994
Altered bactericidal activity against Staphylococcus aureus in tuberculous bronchoalveolar lavage fluids. P. Selvaraj, N. Venkataprasad, V.K. Vijayan, P.R. Narayanan. ©ERS Journals Ltd 1994.
Narayanan, P R   +3 more
core  

Metabolome response to temperature-induced virulence gene expression in two genotypes of pathogenic Vibrio parahaemolyticus [PDF]

open access: yes, 2016
Relative concentration of metabolites identified in Vibrio parahaemolyticus ATCC17802. (XLSX 113 kb)
Bo Feng   +4 more
core   +3 more sources

Lysophospholipid G Protein-coupled Receptors [PDF]

open access: yesJournal of Biological Chemistry, 2004
The many biological responses documented for lysophospholipids that include lysophosphatidic acid and sphingosine 1-phosphate can be mechanistically attributed to signaling through specific G protein-coupled receptors. At least nine receptors have now been identified, and the total number is likely to be larger.
Brigitte, Anliker, Jerold, Chun
openaire   +2 more sources

Identification of Blood Pressure‐Associated Metabolites by Integrating Metabolomic and Genetic Analysis

open access: yesMedComm, Volume 7, Issue 4, April 2026.
This study identified 10 potential causality between metabolites and blood pressure and found potential genetic regulators of two metabolites. Multiomics integration revealed that a genetic variant near the omega‐3 metabolism genes (FADS1/FADS2) may influence blood pressure regulation by modulating prostaglandin E3 levels.
Yuanjiao Liu   +5 more
wiley   +1 more source

Cell type‐selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment

open access: yesMolecular Oncology, 2019
The peritoneal fluid of ovarian carcinoma patients promotes cancer cell invasion and metastatic spread with lysophosphatidic acid (LPA) as a potentially crucial mediator.
Silke Reinartz   +17 more
doaj   +1 more source

Differential lipid metabolism in monocytes and macrophages: influence of cholesterol loading[S]

open access: yesJournal of Lipid Research, 2016
The influence of the hypercholesterolemia associated with atherosclerosis on monocytes is poorly understood. Monocytes are exposed to high concentrations of lipids, particularly cholesterol and lysophosphatidylcholine (lyso-PC).
Irene Fernandez-Ruiz   +4 more
doaj   +1 more source

In Vitro Modeling of Age‐Associated Lipid Mediator's Impact on Vascular Biology Following Platelet Concentrate Transfusion

open access: yesAging Cell, Volume 25, Issue 4, April 2026.
Age‐associated LPA affects adverse reactions and alters platelet and endothelial biology following platelet concentrate transfusion. Age‐associated LPC, S1P could be involved in adverse reactions, in platelet and endothelium biology following a PC transfusion.
Amelie Prier   +10 more
wiley   +1 more source

Targeting the LPI/GPR55 Axis in MAFLD and MASH: Novel Insights, Therapeutic Strategies and Future Directions

open access: yesLiver International, Volume 46, Issue 4, April 2026.
ABSTRACT Metabolic dysfunction‐associated fatty liver disease (MAFLD), recently redefined from non‐alcoholic fatty liver disease (NAFLD), highlights the central role of metabolic dysfunction in its pathophysiology. The L‐α‐lysophosphatidylinositol/G protein‐coupled receptor 55 (LPI/GPR55) axis, an element of the endocannabinoidome, has emerged as a key
Jerome Lian   +3 more
wiley   +1 more source

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