Results 71 to 80 of about 929 (218)
Molecular Therapy: Nucleic Acids, 2013 Krabbe disease is a devastating neurodegenerative lysosomal storage disorder caused by a deficiency of β-galactocerebrosidase (GALC). Gene therapy is a promising therapeutic approach for Krabbe disease.
Xing-Li Meng +3 more
doaj +1 more source
Metabolic Lysosomal Enzyme Probes
The FASEB Journal, 2008 Lysosomes are acidic cytoplasmic organelles that are present in all nucleated mammalian cells. Lysosomes have been found to be involved in a variety of cellular processes including repair of the plasma membrane, defense against pathogens, cholesterol homeostasis, bone remodeling, metabolism, apoptosis and cell signaling.
John Joseph Naleway +3 more
openaire +1 more source
From RNA to DNA: How Cargo Identity Reprograms Lipid Nanoparticle Architecture and Function
Advanced Healthcare Materials, EarlyView.The evolution of lipid nanoparticles (LNPs) spans from RNA‐LNPs, used in mRNA vaccines, to DNA‐LNPs, ideal for gene therapies. Emerging bionano architectures, decorated with DNA and plasma proteins, pave the way for advanced DNA‐based therapies that are more stable, targeted, and customizable.
Erica Quagliarini +2 more
wiley +1 more source
Induced pluripotent stem cell models of lysosomal storage disorders
Disease Models & Mechanisms, 2017 Induced pluripotent stem cells (iPSCs) have provided new opportunities to explore the cell biology and pathophysiology of human diseases, and the lysosomal storage disorder research community has been quick to adopt this technology.
Daniel K. Borger +5 more
doaj +1 more source
Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction
Advanced Healthcare Materials, EarlyView.Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang +4 more
wiley +1 more source
Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy
Advanced Materials, EarlyView.Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa +3 more
wiley +1 more source
Journal of Functional BiomaterialsExtracellular vesicles (EVs) can be isolated from biological fluids and cell culture medium. Their nanometric dimension, relative stability, and biocompatibility have raised considerable interest for their therapeutic use as delivery vehicles of ...
Eleonora Calzoni +9 more
doaj +1 more source
A Novel Method of Imaging Lysosomes in Living Human Mammary Epithelial Cells
Molecular Imaging, 2003 Cancer cells invade by secreting degradative enzymes which, under normal conditions, are sequestered in lysosomal vesicles. The ability to noninvasively label lysosomes and track lysosomal trafficking would be extremely useful to understand the ...
Kristine Glunde +3 more
doaj +1 more source
Brazilian Journal of Medical and Biological Research, 2000 This study was designed to evaluate the effect of different conditions of collection, transport and storage on the quality of blood samples from normal individuals in terms of the activity of the enzymes ß-glucuronidase, total hexosaminidase ...
M. Burin +5 more
doaj +1 more source
Lysosomal Enzymes in Meningioma
Neurologia medico-chirurgica, 1978 Thirty-nine samples of meningiomas were studied with respect to activities of N-acetyl-glucosaminidase, β-glucuronidase, acid phosphatase, and arylsulfatase. Meningiomas were classified as meningotheliomatous (4), transitional (12), fibroblastic (6), angioblastic (3), malignant (11), and unclassified types (3).
HIROSHI ABE +4 more
openaire +2 more sources