Results 11 to 20 of about 249,586 (383)
Lysosome Transport as a Function of Lysosome Diameter [PDF]
PLoS ONE, 2014 Lysosomes are membrane-bound organelles responsible for the transport and degradation of intracellular and extracellular cargo. The intracellular motion of lysosomes is both diffusive and active, mediated by motor proteins moving lysosomes along microtubules. We sought to determine how lysosome diameter influences lysosome transport.
Christine K. Payne +4 more
openaire +5 more sources
EMBO Molecular Medicine, 2016 In the early 50s, Christian De Duve identified a new cellular structure, the lysosome, defined as the cell's “suicide bag” (de Duve, ). Sixty years later, it is clear that the lysosome greatly exceeded the expectations of its discoverer. Over 50 different types of lysosomal storage diseases have been identified, each due to the deficiency or ...
Andrea Ballabio
openaire +6 more sources
High lumenal chloride in the lysosome is critical for lysosome function
eLife, 2017 AbstractLysosomes are organelles responsible for the breakdown and recycling of cellular machinery. Dysfunctional lysosomes give rise to lysosomal storage disorders as well as common neurodegenerative diseases. Here, we use a DNA-based, fluorescent chloride reporter to measure lysosomal chloride inCaenorhabditis elegansas well as murine and human cell ...
Kasturi Chakraborty +2 more
openaire +7 more sources
The mTOR–lysosome axis at the centre of ageing
FEBS Open Bio, 2021 Age‐related diseases represent some of the largest unmet clinical needs of our time. While treatment of specific disease‐related signs has had some success (for example, the effect of statin drugs on slowing progression of atherosclerosis), slowing ...
Julian M. Carosi +3 more
semanticscholar +2 more sources
Reactive oxygen species prevent lysosome coalescence during PIKfyve inhibition.
PLoS ONE, 2021 Lysosomes are terminal, degradative organelles of the endosomal pathway that undergo repeated fusion-fission cycles with themselves, endosomes, phagosomes, and autophagosomes. Lysosome number and size depends on balanced fusion and fission rates.
Golam T Saffi +6 more
doaj +1 more source
Orphanet Journal of Rare Diseases, 2021 Parents of children with severe inborn errors of metabolism frequently face stressful events related to the disease of their child and are consequently at high risk for developing parental posttraumatic stress disorder (PTSD).
Thirsa Conijn +3 more
doaj +1 more source
Scientific Reports, 2021 We have previously shown that the DBA/2J versus AKR/J mouse strain is associated with decreased autophagy-mediated lysosomal hydrolysis of cholesterol esters. Our objective was to determine differences in lysosome function in AKR/J and DBA/2J macrophages,
Peggy Robinet +7 more
doaj +1 more source
ER – lysosome contacts at a pre-axonal region regulate axonal lysosome availability
Nature Communications, 2021 In neurons and other cells, contacts between organelles regulates function and subcellular organization, but the precise mechanisms and effects are unclear.
Nazmiye Özkan +9 more
doaj +1 more source
RUFY3 links Arl8b and JIP4-Dynein complex to regulate lysosome size and positioning
Nature Communications, 2022 The bidirectional movement of lysosomes on microtubule tracks regulates their whole-cell spatial arrangement. Arl8b, a small GTP-binding (G) protein, promotes lysosome anterograde trafficking mediated by kinesin-1.
G. Kumar +7 more
semanticscholar +1 more source
Inhibition of glioma cell lysosome exocytosis inhibits glioma invasion. [PDF]
PLoS ONE, 2012 Cancer cells invade by secreting enzymes that degrade the extracellular matrix and these are sequestered in lysosomal vesicles. In this study, the effects of the selective lysosome lysing drug GPN and the lysosome exocytosis inhibitor vacuolin-1 on ...
Yu Liu, Yijiang Zhou, Keqing Zhu
doaj +1 more source