Results 31 to 40 of about 231,658 (339)

Nanodrugs Detonate Lysosome Bombs

Frontiers in Pharmacology, 2022
Cancer cell lysosomes contain various hydrolases and non-degraded substrates that are corrosive enough to destroy cancer cells. However, many traditional small molecule drugs targeting lysosomes have strong side effects because they cannot effectively ...
Yuting Xiang, Niansheng Li, Min Liu, Min Liu, Qiaohui Chen, Xingyu Long, Yuqi Yang, Yuqi Yang, Zuoxiu Xiao, Jia Huang, Jia Huang, Xiaoyuan Wang, Xiaoyuan Wang, Yunrong Yang, Yunrong Yang, Jinping Zhang, Jinping Zhang, Chong Liu, Chong Liu, Qiong Huang, Qiong Huang   +20 more
doaj   +1 more source

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome [PDF]

, 2009
Expansion of the polyglutamine repeat within the protein Huntingtin (Htt) causes Huntington's disease, a neurodegenerative disease associated with aging and the accumulation of mutant Htt in diseased neurons.
Aiken, Ali Khoshnan, Alice L. Lau, Ana Maria Cuervo, Anne, Apostol, Arrasate, Arrasate, Ashish Massey, Atwal, Atwal, Björkqvist, Brown, Charity T. Aiken, Chen, Chondrogianni, Cornett, Cuervo, Cuervo, Cuervo, D'Orazi, Dan, Donald C. Lo, Fang, Finkbeiner, Frank M. LaFerla, Gillian Bates, Graham, Grossman, Gu, Guerrero, Gutekunst, Hasan Khashwji, Henn, Hernandez-Hernandez, Hietakangas, Hofmann, Hu, Huang, Humbert, Hunter, J. Lawrence Marsh, Jacqueline Gire O'Rourke, Jeong, Jiang, Joan S. Steffan, Karin, Karin, Katalin Illes, Kaushik, Kazantsev, Khoshnan, Khoshnan, Kim N. Green, Komatsu, Lan Huang, Leslie Michels Thompson, Linda S. Kaltenbach, Liu, Lo, Luo, Mangiarini, Marta Martinez-Vincente, Martinez-Vicente, Massey, Massey, Michael R. Hayden, Michels, Mizushima, Montserrat Arrasate, Namita Agrawal, Orr, Paul H. Patterson, Peters-Libeu, Rockabrand, Saudou, Schilling, Scott O. Zeitlin, Shao, Southwell, Steffan, Steffan, Steffan, Steven Finkbeiner, Tagwerker, Tamas Lukacsovich, Tonoki, Verma, Walker, Warby, Warby, Warby, Wu, Xia, Ya-Zhen Zhu, Yanai, Zhang, Zuccato   +97 more
core   +3 more sources

Screening of four lysosome-related genes in sepsis based on RNA sequencing technology

BMC Immunology, 2023
Purpose Screening of lysosome-related genes in sepsis patients to provide direction for lysosome-targeted therapy. Methods Peripheral blood samples were obtained from 22 patients diagnosed with sepsis and 10 normal controls for the purpose of RNA ...
Guihong Chen, Wen Zhang, Chenglin Wang, Muhu Chen, Yingchun Hu, Zheng Wang   +5 more
doaj   +1 more source

Lysosome Depletion-Triggered Autophagy Impairment in Progressive Kidney Injury

Kidney Diseases, 2021
Background: Macroautophagy (autophagy) is a cellular recycling process involving the destruction of damaged organelles and proteins in intracellular lysosomes for efficient nutrient reuse.
Xiao-cui Chen, Zhi-hang Li, Chen Yang, Ji-xin Tang, Hui-yao Lan, Hua-feng Liu   +5 more
doaj   +1 more source

Reprogramming of lysosomal gene expression by interleukin-4 and Stat6. [PDF]

, 2013
BACKGROUND: Lysosomes play important roles in multiple aspects of physiology, but the problem of how the transcription of lysosomal genes is coordinated remains incompletely understood.
Bartlett, NW, Brignull, LM, Czimmerer, Z, Daniel, B, Johnston, SL, Meira, LB, Nagy, L, Nohturfft, A, Saidi, H, Villela, I   +9 more
core   +2 more sources

Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration. [PDF]

, 2018
Nematode EAK-7 (enhancer-of-akt-1-7) regulates dauer formation and controls life span; however, the function of the human ortholog mammalian EAK-7 (mEAK-7) is unknown.
Fox, Alexandra Lucienne, Kim, Jin Koo, Krebsbach, Paul H, Mendonça, Daniela Baccelli, Nguyen, Joe Truong, Ray, Connor   +5 more
core   +2 more sources

The role of lysosome in regulated necrosis

Acta Pharmaceutica Sinica B, 2020
Lysosome is a ubiquitous acidic organelle fundamental for the turnover of unwanted cellular molecules, particles, and organelles. Currently, the pivotal role of lysosome in regulating cell death is drawing great attention.
Aqu Alu, Xuejiao Han, Xuelei Ma, Min Wu, Yuquan Wei, Xiawei Wei   +5 more
doaj   +1 more source

High lumenal chloride in the lysosome is critical for lysosome function

eLife, 2017
Lysosomes are organelles responsible for the breakdown and recycling of cellular machinery. Dysfunctional lysosomes give rise to lysosomal storage disorders as well as common neurodegenerative diseases.
Kasturi Chakraborty, KaHo Leung, Yamuna Krishnan   +2 more
doaj   +1 more source

Cytoplasmic Flow and Mixing Due to Deformation of Motile Cells. [PDF]

, 2017
The cytoplasm of a living cell is a dynamic environment through which intracellular components must move and mix. In motile, rapidly deforming cells such as human neutrophils, bulk cytoplasmic flow couples cell deformation to the transport and dispersion
Chan, Caleb K, Koslover, Elena F, Theriot, Julie A   +2 more
core   +2 more sources

Enhancement of lysosome biogenesis as a potential therapeutic approach for neurodegenerative diseases

Neural Regeneration Research, 2023
Millions of people are suffering from Alzheimer’s disease globally, but there is still no effective treatment for this neurodegenerative disease. Thus, novel therapeutic approaches for Alzheimer’s disease are needed, which requires further evaluation of ...
Wenlong Xue, Jie Zhang, Yang Li
doaj   +1 more source