Results 41 to 50 of about 249,586 (383)

Regulators of Lysosome Function and Dynamics in Caenorhabditis elegans

G3: Genes, Genomes, Genetics, 2017
Lysosomes, the major membrane-bound degradative organelles, have a multitude of functions in eukaryotic cells. Lysosomes are the terminal compartments in the endocytic pathway, though they display highly dynamic behaviors, fusing with each other and with
Kevin Gee, Danniel Zamora, Teresa Horm, Laeth George, Cameron Upchurch, Justin Randall, Colby Weaver, Caitlin Sanford, Austin Miller, Sebastian Hernandez, Hope Dang, Hanna Fares   +11 more
doaj   +1 more source

Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration. [PDF]

, 2018
Nematode EAK-7 (enhancer-of-akt-1-7) regulates dauer formation and controls life span; however, the function of the human ortholog mammalian EAK-7 (mEAK-7) is unknown.
Fox, Alexandra Lucienne, Kim, Jin Koo, Krebsbach, Paul H, Mendonça, Daniela Baccelli, Nguyen, Joe Truong, Ray, Connor   +5 more
core   +2 more sources

Lysosome

Journal of Inborn Errors of Metabolism and Screening, 2016
Since Christian de Duve first described the lysosome in the 1950s, it has been generally presented as a membrane-bound compartment containing acid hydrolases that enables the cell to degrade molecules without being digested by autolysis.
Ursula Matte BSc, PhD, Gabriela Pasqualim BSc, MSc   +1 more
doaj   +1 more source

Phenylboronic Acid Modification Augments the Lysosome Escape and Antitumor Efficacy of a Cylindrical Polymer Brush-Based Prodrug.

Journal of the American Chemical Society, 2021
Timely lysosome escape is of paramount importance for endocytosed nanomedicines to avoid premature degradation under the acidic and hydrolytic conditions in lysosomes.
Ruonan Wang, Changfeng Yin, Changren Liu, Ying Sun, P. Xiao, Jia Li, Shuo Yang, Wei Wu, Xiqun Jiang   +8 more
semanticscholar   +1 more source

Direct lysosome-based autophagy of lipid droplets in hepatocytes

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Lipid droplets (LDs) are specialized fat-storage organelles that can be used as a fuel source by many types of cells when nutrients are scarce. One mechanism used by hepatocytes (the functional cells of the liver) for the catabolism of these
Ryan J. Schulze, E. Krueger, S. Weller, Katherine M. Johnson, C. Casey, Micah B. Schott, M. McNiven   +6 more
semanticscholar   +1 more source

α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes

PLoS Biology, 2021
The accumulation of α-synuclein (α-syn) aggregates in specific brain regions is a hallmark of synucleinopathies including Parkinson disease (PD). α-Syn aggregates propagate in a “prion-like” manner and can be transferred inside lysosomes to recipient ...
Aysegul Dilsizoglu Senol, M. Samarani, S. Syan, Carlos M. A. Guardia, T. Nonaka, N. Liv, P. Latour-Lambert, M. Hasegawa, J. Klumperman, J. Bonifacino, C. Zurzolo   +10 more
semanticscholar   +1 more source

Lysosome-mediated processing of chromatin in senescence [PDF]

, 2013
Cellular senescence is a stable proliferation arrest, a potent tumor suppressor mechanism, and a likely contributor to tissue aging. Cellular senescence involves extensive cellular remodeling, including of chromatin structure. Autophagy and lysosomes are
Adams, Adams-Cioaba, Andre Ivanov, Barnhill, Barradas, Bodnar, Braig, Bridger, Butin-Israeli, Cao, Chen, Chen, Coffinier, Collado, Cosme-Blanco, Dang, David M. Nelson, De Cecco, De Cecco, De Vos, Demidenko, Di Micco, Duncan, Feldser, Feser, Fraga, Freund, Funayama, Glatz, Goldman, Graeme Hewitt, Gray-Schopfer, Gray-Schopfer, Greer, Hayflick, Hong Wu, Houben, Howard, Hunt, Ichijima, Iglesias-Bartolome, Imai, Indrani Manoharan, Ishidoh, Jeff Pawlikowski, Joao F. Passos, John van Tuyn, Kanfi, Kang, Kennedy, Klionsky, Kreiling, Krizhanovsky, Krtolica, Kuilman, Lamark, Laszlo, Lee, Maures, McManus, Michaloglou, Michishita, Narita, Narita, Narita, Omholt, O’Sullivan, Pankiv, Parisha P. Shah, Passos, Peleg, Peter D. Adams, Pollock, Pospelova, Ruhoy, Sagiv, Santos-Rosa, Scaffidi, Serrano, Shelley L. Berger, Shimi, Shimi, Siebold, Smolle, Smolle, Soutoglou, Suram, Taranjit Singh Rai, Tran, Vargas, Vergnes, Viktor I. Korolchuk, Villeponteau, Wang, Wood, Xue, Yang, Young, Zhang, Zhang, Ziegler-Birling   +100 more
core   +2 more sources

ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling

bioRxiv, 2021
Mutations in VPS13C cause early onset, autosomal recessive Parkinson’s Disease (PD). We have established that VPS13C encodes a lipid transfer protein localized to contact sites between the endoplasmic reticulum (ER) and late endosomes/lysosomes.
William Hancock-Cerutti, Zheng Wu, A. Tharkeshwar, S. Ferguson, G. Shadel, P. De Camilli   +5 more
semanticscholar   +1 more source

Inositol Triphosphate Signaling Triggers Lysosome Biogenesis Via Calcium Release from Endoplasmic Reticulum Stores

Contact, 2022
Lysosomes serve as cellular degradation and signaling centers that coordinate the turnover of macromolecules with cell metabolism. The adaptation of cellular lysosome content and activity via the induction of lysosome biogenesis is therefore key to cell ...
Mouhannad Malek, Volker Haucke
doaj   +1 more source

Lysosome Depletion-Triggered Autophagy Impairment in Progressive Kidney Injury

Kidney Diseases, 2021
Background: Macroautophagy (autophagy) is a cellular recycling process involving the destruction of damaged organelles and proteins in intracellular lysosomes for efficient nutrient reuse.
Xiao-cui Chen, Zhi-hang Li, Chen Yang, Ji-xin Tang, Hui-yao Lan, Hua-feng Liu   +5 more
doaj   +1 more source