Results 71 to 80 of about 44,822 (222)

Lytic Phages against ST11 K47 Carbapenem-Resistant Klebsiella pneumoniae and the Corresponding Phage Resistance Mechanisms

open access: yesmSphere, 2022
We isolated and characterized a novel phage from hospital sewage, P13, able to lyse ST11 K47 carbapenem-resistant Klebsiella pneumoniae (CRKP), a major CRKP lineage.
Qingqing Fang, Zhiyong Zong
doaj   +1 more source

Propionibacterium acnes bacteriophages display limited genetic diversity and broad killing activity against bacterial skin isolates. [PDF]

open access: yes, 2012
UnlabelledInvestigation of the human microbiome has revealed diverse and complex microbial communities at distinct anatomic sites. The microbiome of the human sebaceous follicle provides a tractable model in which to study its dominant bacterial ...
Bowman, Charles   +13 more
core   +2 more sources

Pyroptosis‐Inducing Engineered Microparticles for Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
Engineered microparticles co‐delivering geldanamycin and dual nanobodies induce targeted pyroptosis and block PD‐L1 and CD47 pathways, reprogramming the tumor microenvironment and achieving potent antitumor immunity in lung cancer models with minimal toxicity.
Tianli Hao   +12 more
wiley   +1 more source

Biological characteristics and preliminary genome analysis of Acinetobacter baumannii bacteriophage SWH-Ab-3

open access: yesDi-san junyi daxue xuebao, 2019
Objective To investigate the biological characteristics and basic genomic information of Acinetobacter baumannii (A. baumannii) lytic bacteriophage isolated from hospital sewage.
ZHANG Ran   +5 more
doaj   +1 more source

Inhibition of Targeted Bacterial Growth Using MazF‐Expressing Phagemids: A Novel Therapeutic Approach Based on Endoribonuclease Toxin Molecules

open access: yesMicrobiology and Immunology, EarlyView.
ABSTRACT The extensive and indiscriminate use of antibiotics, which are intended to halt bacterial growth or eliminate them, has unintentionally given rise to antimicrobial resistance (AMR), which is a critical threat to global health. In the pursuit of alternative solutions, researchers have focused on type II toxin–antitoxin systems prevalent within ...
Hana Hasegawa   +6 more
wiley   +1 more source

Characterization of Pseudomonas aeruginosa Bacteriophage L5 Which Requires Type IV Pili for Infection

open access: yesFrontiers in Microbiology, 2022
Pseudomonas aeruginosa is a common opportunistic human pathogen. With the emergence of multidrug-resistant (MDR) clinical infection of P. aeruginosa, phage therapy has received renewed attention in treating P. aeruginosa infections.
Lan Yang   +10 more
doaj   +1 more source

Molecular Characterisation of Bacteriophage K Towards Applications for the Biocontrol of Pathogenic Staphylococci [PDF]

open access: yes, 2006
End of project reportThe aim of this work was to characterise staphylococcal bacteriophage (a bacterial virus) and to assess their potential as therapeutic agents against pathogenic strains of Staphylococcus aureus, particularly mastitis-causing strains.
Coffey, Aidan   +5 more
core  

Phage Therapy: Targeting the Gut Microbiota for the Treatment of Acute Pancreatitis

open access: yesJournal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Acute pancreatitis (AP) is a common clinical inflammatory condition whose severity is closely associated with both local pancreatic injury and systemic complications. Research indicates that gut microbiota dysbiosis and subsequent bacterial translocation can exacerbate disease progression via the gut–pancreas axis, representing a critical ...
Jiawei Chen   +4 more
wiley   +1 more source

The Role of Viruses in the Pathogenesis of Periodontitis

open access: yesJournal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte   +2 more
wiley   +1 more source

Comparative Genomics of 9 Novel Paenibacillus Larvae Bacteriophages [PDF]

open access: yes, 2016
American Foulbrood Disease, caused by the bacterium Paenibacillus larvae, is one of the most destructive diseases of the honeybee, Apis mellifera. Our group recently published the sequences of 9 new phages with the ability to infect and lyse P.
Amy, Penny S.   +4 more
core   +2 more sources

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