Bulgecin A: The Key to a Broad‐Spectrum Inhibitor That Targets Lytic Transglycosylases [PDF]
Antibiotics, 2017 Lytic transglycosylases (Lts) are involved in recycling, cell division, and metabolism of the peptidoglycan. They have been understudied for their usefulness as potential antibacterial targets due to their high redundancy in Gram‐negative bacteria ...
Allison H. Williams +5 more
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The lytic transglycosylase, LtgG, controls cell morphology and virulence in Burkholderia pseudomallei [PDF]
Scientific Reports, 2019 Burkholderia pseudomallei is the causative agent of the tropical disease melioidosis. Its genome encodes an arsenal of virulence factors that allow it, when required, to switch from a soil dwelling bacterium to a deadly intracellular pathogen.
Christopher H. Jenkins +8 more
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A lytic transglycosylase connects bacterial focal adhesion complexes to the peptidoglycan cell wall [PDF]
eLifeThe Gram-negative bacterium Myxococcus xanthus glides on solid surfaces. Dynamic bacterial focal adhesion complexes (bFACs) convert proton motive force from the inner membrane into mechanical propulsion on the cell surface.
Carlos A Ramirez Carbo +2 more
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The vertebrate lysozyme inhibitor Ivy functions to inhibit the activity of lytic transglycosylase. [PDF]
J Biol Chem, 2010 The proteinaceous inhibitor of vertebrate lysozymes (Ivy) is produced by a collection of Gram-negative bacteria as a stress response to damage to their essential cell wall component peptidoglycan. A paralog of Ivy, Ivyp2 is produced exclusively by a number of pseudomonads, including Pseudomonas aeruginosa, but this protein does not inhibit the ...
Clarke CA, Scheurwater EM, Clarke AJ.
europepmc +7 more sources
Soluble lytic transglycosylase SLT of Francisella novicida is involved in intracellular growth and immune suppression. [PDF]
PLoS ONE, 2019 Francisella tularensis, a category-A bioterrorism agent causes tularemia. F. tularensis suppresses the immune response of host cells and intracellularly proliferates.
Takemasa Nakamura +4 more
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Lytic transglycosylases mitigate periplasmic crowding by degrading soluble cell wall turnover products [PDF]
eLife, 2022 The peptidoglycan cell wall is a predominant structure of bacteria, determining cell shape and supporting survival in diverse conditions. Peptidoglycan is dynamic and requires regulated synthesis of new material, remodeling, and turnover – or autolysis –
Anna Isabell Weaver +7 more
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Cwp19 Is a Novel Lytic Transglycosylase Involved in Stationary-Phase Autolysis Resulting in Toxin Release in
mBio, 2018 Clostridium difficile is the major etiologic agent of antibiotic-associated intestinal disease. Pathogenesis of C. difficile is mainly attributed to the production and secretion of toxins A and B.
Sandra Wydau-Dematteis +11 more
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Glycan strand cleavage by a lytic transglycosylase, MltD contributes to the expansion of peptidoglycan in Escherichia coli. [PDF]
PLoS GeneticsPeptidoglycan (PG) is a protective sac-like exoskeleton present in most bacterial cell walls. It is a large, covalently crosslinked mesh-like polymer made up of many glycan strands cross-bridged to each other by short peptide chains.
Moneca Kaul +3 more
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Delivery determinants of an Acinetobacter baumannii type VI secretion system bifunctional peptidoglycan hydrolase [PDF]
mBioAcinetobacter baumannii is a Gram-negative opportunistic pathogen and is a common cause of nosocomial infections. The increasing development of antibiotic resistance in this organism is a global health concern. The A.
Valeriya Bezkorovayna +7 more
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Important role of a putative lytic transglycosylase Cj0843c in β-lactam resistance in Campylobacter jejuni [PDF]
Frontiers in Microbiology, 2015 Beta-lactam antibiotics are an important class of antibiotics for treating bacterial infections. Despite prevalent β-lactam resistance in Campylobacter jejuni, the leading bacterial cause of human diarrhea in developed countries, molecular mechanism of β-
Ximin eZeng +2 more
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