Bulgecin A: The Key to a Broad‐Spectrum Inhibitor That Targets Lytic Transglycosylases [PDF]
Antibiotics, 2017 Lytic transglycosylases (Lts) are involved in recycling, cell division, and metabolism of the peptidoglycan. They have been understudied for their usefulness as potential antibacterial targets due to their high redundancy in Gram‐negative bacteria ...
Allison H. Williams +5 more
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Exploitation of a Bacterium-Encoded Lytic Transglycosylase by a Human Oral Lytic Phage To Facilitate Infection. [PDF]
J Virol, 2022 The evidence for the presence of a diverse and abundant phage population in the host-associated oral microbiome came largely from metagenomic analysis or the observation of virus-like particles within saliva/plaque samples, while the isolation of oral phage and investigation of their interaction with bacterial hosts are limited.
Cen L +12 more
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The lytic transglycosylase, LtgG, controls cell morphology and virulence in Burkholderia pseudomallei [PDF]
Scientific Reports, 2019 Burkholderia pseudomallei is the causative agent of the tropical disease melioidosis. Its genome encodes an arsenal of virulence factors that allow it, when required, to switch from a soil dwelling bacterium to a deadly intracellular pathogen.
Christopher H. Jenkins +8 more
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Structural Characterization of Lytic Transglycosylase SltB2 of Pseudomonas aeruginosa [PDF]
ACS OmegaPeer ...
Vega Miguel-Ruano +6 more
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XAC4296 Is a Multifunctional and Exclusive Xanthomonadaceae Gene Containing a Fusion of Lytic Transglycosylase and Epimerase Domains [PDF]
Microorganisms, 2022 Microorganisms have a limited and highly adaptable repertoire of genes capable of encoding proteins containing single or variable multidomains. The phytopathogenic bacteria Xanthomonas citri subsp. citri (X.
Amanda C. P. de Oliveira +6 more
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An atypical orphan carbohydrate-NRPS genomic island encodes a novel lytic transglycosylase. [PDF]
Chem Biol, 2014 Microbial genome sequencing platforms have produced a deluge of orphan biosynthetic pathways suspected of biosynthesizing new small molecules with pharmacological relevance. Genome synteny analysis provides an assessment of genomic island content, which is enriched in natural product gene clusters.
Guo X, Crawford JM.
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Identification of Membrane-Bound Lytic Murein Transglycosylase A (MltA) as a Growth Factor for Francisella novicida in a Silkworm Infection Model [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 Francisella tularensis, the causative agent of tularemia, is transmitted by arthropod vectors within mammalian hosts. The detailed mechanisms contributing to growth and survival of Francisella within arthropod remain poorly understood.
Takemasa Nakamura +7 more
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Lytic transglycosylases mitigate periplasmic crowding by degrading soluble cell wall turnover products [PDF]
eLife, 2022 The peptidoglycan cell wall is a predominant structure of bacteria, determining cell shape and supporting survival in diverse conditions. Peptidoglycan is dynamic and requires regulated synthesis of new material, remodeling, and turnover – or autolysis –
Anna Isabell Weaver +7 more
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Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis [PDF]
eLife, 2020 Lytic transglycosylases (LT) are enzymes involved in peptidoglycan (PG) remodeling. However, their contribution to cell-wall-modifying complexes and their potential as antimicrobial drug targets remains unclear.
Allison Hillary Williams +13 more
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Glycan strand cleavage by a lytic transglycosylase, MltD contributes to the expansion of peptidoglycan in Escherichia coli. [PDF]
PLoS GeneticsPeptidoglycan (PG) is a protective sac-like exoskeleton present in most bacterial cell walls. It is a large, covalently crosslinked mesh-like polymer made up of many glycan strands cross-bridged to each other by short peptide chains.
Moneca Kaul +3 more
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