Results 21 to 30 of about 4,722 (203)

Important role of a putative lytic transglycosylase Cj0843c in β-lactam resistance in Campylobacter jejuni [PDF]

Frontiers in Microbiology, 2015
Beta-lactam antibiotics are an important class of antibiotics for treating bacterial infections. Despite prevalent β-lactam resistance in Campylobacter jejuni, the leading bacterial cause of human diarrhea in developed countries, molecular mechanism of β-
Ximin eZeng, Barbara eGillespie, Jun eLin   +2 more
doaj   +2 more sources

A Francisella novicida Mutant, Lacking the Soluble Lytic Transglycosylase Slt, Exhibits Defects in Both Growth and Virulence [PDF]

Frontiers in Microbiology, 2019
Francisella tularensis is the causative agent of tularemia and has gained recent interest as it poses a significant biothreat risk. F. novicida is commonly used as a laboratory surrogate for tularemia research due to genetic similarity and susceptibility
Beth A. Bachert, Sergei S. Biryukov, Jennifer Chua, Sabrina A. Rodriguez, Ronald G. Toothman, Christopher K. Cote, Christopher P. Klimko, Melissa Hunter, Jennifer L. Shoe, Janice A. Williams, Kathleen A. Kuehl, Fabrice V. Biot, Joel A. Bozue   +12 more
doaj   +2 more sources

Structural studies and molecular dynamics simulations suggest a processive mechanism of exolytic lytic transglycosylase from Campylobacter jejuni. [PDF]

PLoS ONE, 2018
The bacterial soluble lytic transglycosylase (LT) breaks down the peptidoglycan (PG) layer during processes such as cell division. We present here crystal structures of the soluble LT Cj0843 from Campylobacter jejuni with and without bulgecin A inhibitor
Jagamya Vijayaraghavan, Vijay Kumar, Nikhil P Krishnan, Ross T Kaufhold, Ximin Zeng, Jun Lin, Focco van den Akker   +6 more
doaj   +2 more sources

Turnover Chemistry and Structural Characterization of the Cj0843c Lytic Transglycosylase of Campylobacter jejuni. [PDF]

Biochemistry, 2021
Kumar V, Mathure SA, Lee M, Boorman J, Zeng X, Lin J, Hesek D, Lastochkin E, Mobashery S, van den Akker F.   +9 more
europepmc   +3 more sources

The 22 kDa endo-specific membrane-bound lytic transglycosylase EmtA [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 2000
Francesca Gliubich, A.M.W.H. Thunnissen, Bauke W. Dijkstra   +2 more
openalex   +3 more sources

Coordinated Transcriptional Increases in Cell Wall Synthesis Genes in Neisseria gonorrhoeae Lacking the Lytic Transglycosylase, ltgA. [PDF]

Curr Microbiol
Broadie CO, Telchy AI, Baines AT, Dillard JP, Nicholas RA, Williams D.   +5 more
europepmc   +3 more sources

Lytic Transglycosylase Deficiency Increases Susceptibility to β-lactam Antibiotics But Reduces Susceptibility to Vancomycin in Escherichia coli. [PDF]

Microbiol Immunol
ABSTRACT In Staphylococcus aureus, a gram‐positive pathogen, vancomycin‐resistant strains become susceptible to β‐lactam antibiotics, referred to as the “seesaw effect.” However, in gram‐negative bacteria, the phenomenon is less clear. Here, we analyzed the gene‐knockout effects of eight lytic transglycosylases (slt, mltA, mltB, mltC, mltD, mltE, mltF,
Kimura T, Ishikawa K, Nakagawa R, Furuta K, Kaito C.   +4 more
europepmc   +2 more sources

Crystal Structures of the SpoIID Lytic Transglycosylases Essential for Bacterial Sporulation [PDF]

Journal of Biological Chemistry, 2016
Bacterial spores are the most resistant form of life known on Earth and represent a serious problem for (i) bioterrorism attack, (ii) horizontal transmission of microbial pathogens in the community, and (iii) persistence in patients and in a nosocomial environment.
Salvatore Nocadello, G. Minasov, Ludmilla Shuvalova, I. Dubrovska, E. Sabini, W.F. Anderson   +5 more
openalex   +4 more sources

Immunoinformatics-based design and evaluation of a multi-epitope vaccine against Vibrio fluvialis [PDF]

Scientific Reports
Vibrio fluvialis is an emerging foodborne pathogen causing gastroenteritis and extraintestinal infections, representing a significant public health concern due to rising antimicrobial resistance and the absence of an approved vaccine. This study aimed to
Muhammad Naveed, Muhammad Husnain, Tariq Aziz, Parveen Qadir, Muhammad Asim, Muhammad Nouman Majeed, Abeer S Aloufi, Ashwag Shami, Maher S Alwethynani, Nantenaina Tombozara   +9 more
doaj   +2 more sources

Accelerated X-ray Structure Elucidation of a 36 kDa Muramidase/Transglycosylase Using wARP [PDF]

, 1998
The X-ray structure of the 36kDa soluble lytic transglycosylase from Escherichia coli has been determined starting with the multiple isomorphous replacement method with inclusion of anomalous scattering at 2.7 Å resolution. Subsequently, before any model
Asselt, Erik J. van,, Dijkstra, Bauke W.,, Kalk, Kor H.,, Lamzin, Victor S.,, Perrakis, Anastassis,   +4 more
core   +16 more sources