Cell ReportsSummary: Pseudomonas syringae deploys a type III secretion system (T3SS) to deliver effector proteins to facilitate infection of plant cells; however, little is known about the direct interactions between T3SS components and plants.
Jun-Zhou Li +7 more
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Structural studies and molecular dynamics simulations suggest a processive mechanism of exolytic lytic transglycosylase from Campylobacter jejuni. [PDF]
PLoS ONE, 2018 The bacterial soluble lytic transglycosylase (LT) breaks down the peptidoglycan (PG) layer during processes such as cell division. We present here crystal structures of the soluble LT Cj0843 from Campylobacter jejuni with and without bulgecin A inhibitor
Jagamya Vijayaraghavan +6 more
doaj +2 more sources
β-Lactam Resistance in Azospirillum baldaniorum Sp245 Is Mediated by Lytic Transglycosylase and β-Lactamase and Regulated by a Cascade of RpoE7→RpoH3 Sigma Factors. [PDF]
J Bacteriol, 2022 Pandey P +5 more
europepmc +3 more sources
Interaction and modulation of two antagonistic cell wall enzymes of mycobacteria. [PDF]
PLoS Pathogens, 2010 Bacterial cell growth and division require coordinated cell wall hydrolysis and synthesis, allowing for the removal and expansion of cell wall material. Without proper coordination, unchecked hydrolysis can result in cell lysis.
Erik C Hett +2 more
doaj +12 more sources
Crystallization of the soluble lytic transglycosylase from Escherichia coli K12 [PDF]
Journal of Molecular Biology, 1990 Lytic transglycosylases degrade the murein polymer of the bacterial cell wall to 1,6-anhydromuropeptides. These enzymes are of significant medical interest, not only because they are ideal targets for the development of new classes of antibiotics, but also because the low molecular weight products of their catalytic action can cause diverse biological ...
H.J. Rozeboom +3 more
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The Lytic Transglycosylases ofNeisseria gonorrhoeae [PDF]
Microbial Drug Resistance, 2012 Neisseria gonorrhoeae encodes five lytic transglycosylases (LTs) in the core genome, and most gonococcal strains also carry the gonococcal genetic island that encodes one or two additional LTs. These peptidoglycan (PG)-degrading enzymes are required for a number of processes that are either involved in the normal growth of the bacteria or affect the ...
Yolande A. Chan +2 more
openalex +4 more sources
Mycobacteriophage endolysins: diverse and modular enzymes with multiple catalytic activities. [PDF]
PLoS ONE, 2012 The mycobacterial cell wall presents significant challenges to mycobacteriophages--viruses that infect mycobacterial hosts--because of its unusual structure containing a mycolic acid-rich mycobacterial outer membrane attached to an arabinogalactan layer ...
Kimberly M Payne, Graham F Hatfull
doaj +8 more sources
Structure of the Bacteriophage φKZ Lytic Transglycosylase gp144 [PDF]
Journal of Biological Chemistry, 2007 Lytic transglycosylases are enzymes that act on the peptidoglycan of bacterial cell walls. They cleave the glycosidic linkage between N-acetylmuramoyl and N-acetylglucosaminyl residues with the concomitant formation of a 1,6-anhydromuramoyl product. The x-ray structure of the lytic transglycosylase gp144 from the Pseudomonas bacteriophage phi KZ has ...
Andrei Fokine +4 more
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Inhibition of membrane‐bound lytic transglycosylase B by NAG‐thiazoline [PDF]
FEBS Letters, 2004 The lytic transglycosylases cleave the bacterial cell wall heteropolymer peptidoglycan with the same specificity as the muramidases (lysozymes), between the N‐acetylmuramic acid and N‐acetylglucosamine residues, with the concomitant formation of a 1,6‐anhydromuramoyl residue.
Christopher W. Reid +4 more
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Exploitation of a Bacterium-Encoded Lytic Transglycosylase by a Human Oral Lytic Phage To Facilitate Infection. [PDF]
J Virol, 2022 The evidence for the presence of a diverse and abundant phage population in the host-associated oral microbiome came largely from metagenomic analysis or the observation of virus-like particles within saliva/plaque samples, while the isolation of oral phage and investigation of their interaction with bacterial hosts are limited.
Cen L +12 more
europepmc +5 more sources