The 22 kDa endo-specific membrane-bound lytic transglycosylase EmtA [PDF]
Acta Crystallographica Section A Foundations of Crystallography, 2000 Francesca Gliubich +2 more
openalex +4 more sources
Growth of Porphyromonas gingivalis on human serum albumin triggers programmed cell death
Journal of Oral Microbiology, 2023 Aims Gingival crevicular fluid (GCF) constitutes the primary growth substrate for Porphyromonas gingivalis in vivo. The goal of this work was to evaluate the growth of different strains of P.
Shirin Ghods +4 more
doaj +1 more source
Frontiers in Microbiology, 2023 Peptidoglycan, found within the cell wall of bacteria, is a structure critical for maintaining cell morphology and providing a protective barrier in diverse environments. Peptidoglycan is a remarkably dynamic structure that is constantly remodeled during
Beth A. Bachert, Joel A. Bozue
doaj +1 more source
Lytic transglycosylases: concinnity in concision of the bacterial cell wall [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2017 The lytic transglycosylases (LTs) are bacterial enzymes that catalyze the non-hydrolytic cleavage of the peptidoglycan structures of the bacterial cell wall. They are not catalysts of glycan synthesis as might be surmised from their name. Notwithstanding the seemingly mundane reaction catalyzed by the LTs, their lytic reactions serve bacteria for a ...
David A. Dik +3 more
openaire +3 more sources
The mechanistic landscape of Lytic transglycosylase as targets for antibacterial therapy
Current Opinion in Structural Biology, 2022 Lytic transglycosylases (Ltgs) are glycan strand cleaving enzymes whose role is poorly understood in the genesis of the bacterial envelope. They play multiple roles in all stages of a bacterial life cycle, by creating holes in the peptidoglycan that is necessary for cell division and separation.
Elizabeth A. Martinez-Bond +2 more
openaire +2 more sources
Subcellular distribution of the soluble lytic transglycosylase in Escherichia coli [PDF]
Journal of Bacteriology, 1991 The localization of the major autolytic enzyme, the soluble lytic transglycosylase, in the different cell compartments of Escherichia coli was investigated by immunoelectron microscopy. Ultrathin sections were labeled with a specific antiserum against purified soluble lytic transglycosylase, and the antibody-enzyme complexes were visualized with ...
Joachim-Volker Höltje, B Walderich
openaire +3 more sources
The Effect of NAG–thiazoline on Morphology and Surface Hydrophobicity of Escherichia Coli [PDF]
, 2004 The β-hexosaminidase inhibitor and structural analog of the putative oxazolium reaction intermediate of lytic transglycosylases, N-acetylglucosamine thiazoline (NAG–thiazoline), was synthesized in 46% overall yield and tested as an inhibitor of ...
Blackburn, Neil T. +2 more
core +2 more sources
Antibiotic Targets in Gonococcal Cell Wall Metabolism
Antibiotics, 2018 The peptidoglycan cell wall that encloses the bacterial cell and provides structural support and protection is remodeled by multiple enzymes that synthesize and cleave the polymer during growth.
Krizia M. Pérez Medina +1 more
doaj +1 more source
Structure and cell wall cleavage by modular lytic transglycosylase MltC of Escherichia coli. [PDF]
ACS Chem Biol, 2014 Artola-Recolons C +14 more
europepmc +2 more sources
Lytic transglycosylases in macromolecular transport systems of Gram-negative bacteria
Cellular and Molecular Life Sciences (CMLS), 2003 The cell wall of Gram-negative bacteria is essential for the integrity of the bacterial cell but also imposes a physical barrier to trans-envelope transport processes in which DNA and/or proteins are taken up or secreted by complex protein assemblies.
Günther Koraimann
openalex +4 more sources