Results 51 to 60 of about 4,722 (203)

The Effect of NAG–thiazoline on Morphology and Surface Hydrophobicity of Escherichia Coli [PDF]

, 2004
The β-hexosaminidase inhibitor and structural analog of the putative oxazolium reaction intermediate of lytic transglycosylases, N-acetylglucosamine thiazoline (NAG–thiazoline), was synthesized in 46% overall yield and tested as an inhibitor of ...
Blackburn, Neil T., Clarke, Anthony J., Reid, Christopher W.   +2 more
core   +2 more sources

Lytic transglycosylases: concinnity in concision of the bacterial cell wall [PDF]

Critical Reviews in Biochemistry and Molecular Biology, 2017
The lytic transglycosylases (LTs) are bacterial enzymes that catalyze the non-hydrolytic cleavage of the peptidoglycan structures of the bacterial cell wall. They are not catalysts of glycan synthesis as might be surmised from their name. Notwithstanding the seemingly mundane reaction catalyzed by the LTs, their lytic reactions serve bacteria for a ...
David A. Dik, Daniel R. Marous, Jed F. Fisher, Shahriar Mobashery   +3 more
openaire   +2 more sources

Antibiotic Targets in Gonococcal Cell Wall Metabolism

Antibiotics, 2018
The peptidoglycan cell wall that encloses the bacterial cell and provides structural support and protection is remodeled by multiple enzymes that synthesize and cleave the polymer during growth.
Krizia M. Pérez Medina, Joseph P. Dillard   +1 more
doaj   +1 more source

Comparative Genomics of 9 Novel Paenibacillus Larvae Bacteriophages [PDF]

, 2016
American Foulbrood Disease, caused by the bacterium Paenibacillus larvae, is one of the most destructive diseases of the honeybee, Apis mellifera. Our group recently published the sequences of 9 new phages with the ability to infect and lyse P.
Amy, Penny S., LeBlanc, Lucy, Stamereilers, Casey, Tsourkas, Philippos K., Yost, Diane   +4 more
core   +2 more sources

Lytic transglycosylases: Bacterial space-making autolysins

The International Journal of Biochemistry & Cell Biology, 2008
Lytic transglycosylases are an important class of bacterial enzymes that act on peptidoglycan with the same substrate specificity as lysozyme. Unlike the latter enzymes, however, the lytic transglycosylases are not hydrolases but instead cleave the glycosidic linkage between N-actetylmuramoyl and N-acetylglucosaminyl residues with the concomitant ...
Scheurwater, Edie, Reid, Christopher W., Clarke, Anthony J.   +2 more
openaire   +4 more sources

A SpoIID Homolog Cleaves Glycan Strands at the Chlamydial Division Septum

mBio, 2019
Chlamydiales species are obligate intracellular bacteria lacking a classical peptidoglycan sacculus but relying on peptidoglycan synthesis for cytokinesis.
Nicolas Jacquier, Akhilesh K. Yadav, Trestan Pillonel, Patrick H. Viollier, Felipe Cava, Gilbert Greub   +5 more
doaj   +1 more source

The structure of a resuscitation-promoting factor domain from Mycobacterium tuberculosis shows homology to lysozymes [PDF]

, 2005
Resuscitation-promoting factor (RPF) proteins reactivate stationary-phase cultures of (G+C)-rich Gram-positive bacteria including the causative agent of tuberculosis, Mycobacterium tuberculosis.
AT Brunger, BA Johnson, Brian Henderson, Christian Roumestand, Claire Bagnéris, D Sharma, EJ van Asselt, EJ van Asselt, G Cornilescu, GV Mukamolova, GV Mukamolova, GV Mukamolova, H Song, JB Raymond, JG Lees, JL Pons, JM Tufariello, John Ward, JP Linge, L Holm, M Cohen-Gonsaud, M Cohen-Gonsaud, M Hartmann, Martin Cohen-Gonsaud, Nicholas H Keep, Philippe Barthe, R Koradi, RA Laskowski   +27 more
core   +2 more sources

Molecular characterisation, evolution and expression analysis of g-type lysozymes in Ciona intestinalis [PDF]

, 2017
Lysozyme is an important defense molecule of the innate immune system. Known for its bactericidal properties, lysozyme catalyzes the hydrolysis of b-(1,4)-glycosidic bonds between the N-acetyl glucosamine and N-acetyl muramic acid in the peptidoglycan ...
Cammarata, M., Di Falco, F., Vizzini, A.
core   +1 more source

Characterization ofHelicobacter pyloriLytic Transglycosylases Slt and MltD [PDF]

Journal of Bacteriology, 2006
ABSTRACTPeptidoglycan (PG) is a cell wall heteropolymer that is essential for cell integrity. PG hydrolases participate in correct assembly of the PG layer and have been shown to be required for cell division, cell daughter separation, and maintenance of bacterial morphology. In silico analysis of theHelicobacter pylorigenome resulted in identification
Catherine Chaput, Agnès Labigne, Ivo G. Boneca   +2 more
openalex   +4 more sources

BB0259 Encompasses a Peptidoglycan Lytic Enzyme Function for Proper Assembly of Periplasmic Flagella in Borrelia burgdorferi

Frontiers in Microbiology, 2021
Assembly of the bacterial flagellar rod, hook, and filament requires penetration through the peptidoglycan (PG) sacculus and outer membrane. In most β- and γ-proteobacteria, the protein FlgJ has two functional domains that enable PG hydrolyzing activity ...
Hui Xu, Bo Hu, David A. Flesher, David A. Flesher, Jun Liu, Jun Liu, Md A. Motaleb   +6 more
doaj   +1 more source