Results 91 to 100 of about 26,727 (247)

Calcium homeostasis and role of ryanodine receptor type 1 (RyR1) in immune cells [PDF]

, 2010
Ryanodine receptors are intracellular Ca2+ release channels located in the membrane of the Endoplasmatic/Sarcoplasmatic Reticulum. Ryanodine receptor 1 isoform is preferentially expressed in skeletal muscle where it is responsible for release of Ca2 ...
Vukcevic, Mirko
core   +1 more source

Evolution in the understanding of idiopathic membranous nephropathy pathogenesis: from experimental models to the clinic

Alʹmanah Kliničeskoj Mediciny, 2018
Membranous nephropathy (MN) is the leading cause of nephrotic syndrome in adults. This review describes a 60-year history of MN study and represents an evolution in the understanding of its pathogenesis from experimental models to the clinic.
I. N. Bobkova, P. A. Каkhsurueva, E. V. Stavrovskaya, E. E. Filatova   +3 more
doaj   +1 more source

Updates on intra‐articular corticosteroid administration in horses

Equine Veterinary Education, EarlyView.
Summary Intra‐articular (IA) corticosteroid administration in equine athletes has gained increased attention recently, particularly in racing. Despite widespread corticosteroid use in equine practice for decades, there are still a lack of equine‐specific studies to address key questions related to their use.
K. Tanner, L. Bass, C. Kawcak, L. V. Schnabel, K. L. Hallowell, L. M. Pezzanite   +5 more
wiley   +1 more source

A metabolomic investigation of the effects of vitamin E supplementation in humans

, 2012
Background Vitamin E is a nutrient with both antioxidant and non-antioxidant activities and has been shown to modulate the function of a number of cell types in vitro and in human studies.
John K Lodge, Max Wong, Lodge John K, Lodge, John, Wong, Max, Wong Max   +5 more
core   +1 more source

Mycobacterial lysocardiolipin is exported from phagosomes upon cleavage of cardiolipin by a macrophage-derived lysosomal phospholipase A2. [PDF]

, 2001
Pathogenic mycobacteria are able to survive and proliferate in phagosomes within host macrophages (Mphi). This capability has been attributed in part to their cell wall, which consists of various unique lipids.
Torrelles, Jordi, Torrelles, J., Schaible, UE, Fischer, K, Kaufmann, Stefan H. E., Chatterjee, D., Brennan, Patrick J., Chatterjee, D, Fischer, K., Brennan, PJ, Schaible, U., Brennan, P., Torrelles, J, Kaufmann, S., Fischer, Karsten, Kaufmann, SH, Chatterjee, Delphi, Schaible, Ulrich E.   +17 more
core   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Bakuchiol: From structural mimicry to systems‐level skin biology

International Journal of Cosmetic Science, EarlyView.
Convergent outcomes, divergent mechanisms: bakuchiol vs. retinol. Bakuchiol exhibits functional convergence with retinol in improving extracellular matrix integrity, epidermal differentiation and barrier function, while operating through distinct mechanisms.
Ratan K. Chaudhuri
wiley   +1 more source

The changing epidemiology of human type 2 diabetes–associated atherosclerosis: Pathophysiological mechanisms and emerging treatment possibilities

Journal of Internal Medicine, EarlyView.
Abstract Type 2 diabetes (T2D) is a major global health concern strongly associated with atherosclerosis and subsequent macrovascular complications. These complications are the leading cause of death among T2D patients. Despite a decline in cardiovascular events over the last decade, individuals with T2D still have an approximately doubled risk ...
Dania Al‐Sharify, Jiangming Sun, Andreas Edsfeldt   +2 more
wiley   +1 more source

Expression of phospholipase A2 receptor and IgG4 in patients with membranous nephropathy

, 2018
Lei Liu,1 Baochao Chang,1 Xueping Wu,1 Yaling Guo,1 Yan Pan,1 Lijuan Yang2 1Department of Nephrology, The First Affiliated Hospital of Bengbu Medical College, Anhui, People’s Republic of China; 2Department of Physiology, Bengbu Medical College ...
Pan Y, Liu L, Chang B, Yang L, Guo Y, Wu X   +5 more
core  

Interactive effect of 25-hydroxyvitamin D3 and M-type phospholipase A2 receptor gene polymorphism on the progression of idiopathic membranous nephropathy

Linchuang shenzangbing zazhi
Objective To explore the interaction between 1,25-hydroxyvitamin D3 [25-（OH）D3] and M-type phospholipase A2 receptor 1 （PLA2R1） gene polymorphism in the progression of idiopathic membranous nephropathy （IMN）.
Xian-li Huang, Fei-ya Wen, Yan Hao
doaj   +1 more source