Results 91 to 100 of about 30,858,840 (226)

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Evolution in the understanding of idiopathic membranous nephropathy pathogenesis: from experimental models to the clinic

Alʹmanah Kliničeskoj Mediciny, 2018
Membranous nephropathy (MN) is the leading cause of nephrotic syndrome in adults. This review describes a 60-year history of MN study and represents an evolution in the understanding of its pathogenesis from experimental models to the clinic.
I. N. Bobkova, P. A. Каkhsurueva, E. V. Stavrovskaya, E. E. Filatova   +3 more
doaj   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Anti-Phospholipase A2 Receptor Antibodies in Membranous Nephropathy : from Bench to the Patient [PDF]

, 2014
Membranous Nephropathy (MN) is the leading cause of nephrotic syndrome in adults. Primary or idiopathic Membranous Nephropathy (iMN) has been considered as an organ-specific autoimmune disease with an unknown aetiology.
Graziani, Giorgio, Assandri, Roberto, Podestà, Manuel Alfredo, Monari, Marta, Montanelli, Alessandro   +4 more
core   +1 more source

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source

The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells

, 2008
Activated mast cells are a major source of the eicosanoids PGD(2) and leukotriene C(4) (LTC(4)), which contribute to allergic responses. These eicosanoids are produced following the ERK1/2-dependent activation of cytosolic phospholipase A(2), thus ...
Gilfillan, Alasdair M., Kuehn, Hye Sun, Beaven, Michael A., Swindle, Emily J., Kim, Mi-Sun, Metcalfe, Dean D.   +5 more
core   +2 more sources

Bakuchiol: From structural mimicry to systems‐level skin biology

International Journal of Cosmetic Science, EarlyView.
Convergent outcomes, divergent mechanisms: bakuchiol vs. retinol. Bakuchiol exhibits functional convergence with retinol in improving extracellular matrix integrity, epidermal differentiation and barrier function, while operating through distinct mechanisms.
Ratan K. Chaudhuri
wiley   +1 more source

Identification of caspase 3 motifs and critical aspartate residues in human Phospholipase D1b and Phopsholipase D2a [PDF]

, 2008
Stimulation of mammalian cells frequently initiates phospholipase D-catalysed hydrolysis of phosphatidylcholine in the plasma membrane to yield phosphatidic acid (PA) a novel lipid messenger.
Ladds, Graham, Aletrari, Mina-Olga, Hodgkin, Matthew N., Farquhar, Michelle J., Wright, Michelle H.   +4 more
core   +1 more source

Interactive effect of 25-hydroxyvitamin D3 and M-type phospholipase A2 receptor gene polymorphism on the progression of idiopathic membranous nephropathy

Linchuang shenzangbing zazhi
Objective To explore the interaction between 1,25-hydroxyvitamin D3 [25-（OH）D3] and M-type phospholipase A2 receptor 1 （PLA2R1） gene polymorphism in the progression of idiopathic membranous nephropathy （IMN）.
Xian-li Huang, Fei-ya Wen, Yan Hao
doaj   +1 more source

Genome‐scale evidence for host‐associated lineage divergence in the parasitoid, Microctonus aethiopoides

Insect Molecular Biology, EarlyView.
Host associations are primary drivers of genomic divergence, with clear phylogenetic separation observed between strains associated with Hypera and Sitona weevil hosts. Genomic diversity aligns with reproductive modes: sexually reproducing ancestral lineages maintain high heterozygosity, while derived asexual strains exhibit reduced heterozygosity and ...
Meeran Hussain, Elahe Parvizi, Mark R. McNeill, Angela McGaughran   +3 more
wiley   +1 more source