Reevaluation of mycobacterial phosphatidyl-myo-inositol mannosides (PIMs) as Toll-like receptor 2 (TLR2) agonists. [PDF]
Belkai S +13 more
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Anti-Contactin-1-Associated Membranous Nephropathy Presenting With Subsequent Autoimmune Nodopathy. [PDF]
Visch R +6 more
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Hemostasis-Modulating Proteins from Indian Elapid and Viper Snake Venom: Mechanistic Insights and Therapeutic Opportunities. [PDF]
Kiruthika S +4 more
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Optimization of a Target Antigen Diagnostic Pathway for Membranous Nephropathy. [PDF]
Li W +15 more
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The Phospholipase A<sub>2</sub> Superfamily in Health and Disease: From Lipid Signaling to Inflammation, Cancer, and Neurodegeneration. [PDF]
Sikder MM, Labony SA.
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Specialized Pro-Resolving Mediators at the Ocular Surface: Biosynthesis, Mechanisms, and Therapeutic Potential. [PDF]
Gandhi S, Shokravi A, Buhrow S, Balas M.
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Structure of Human M-Type Phospholipase A2 Receptor Revealed by Cryo-Electron Microscopy
Journal of Molecular Biology, 2017M-type phospholipase A2 receptor (M-PLA2R) is a member of the mannose receptor family and known as the receptor of secretory phospholipase A2s. It has also been identified as the major autoantigen of idiopathic membranous nephropathy, one of the most common causes for nephrotic syndrome in adults.
Yongning He, Longxing Cao, Hua Tang
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The M-type phospholipase A2 receptor (PLA2R) is the major autoantigen of primary membranous nephropathy (MN). Despite many studies on B-cell epitopes recognized by antibodies, little is known about T-cell epitopes. Herein, we synthesized 123 linear peptides, each consisting of 15-22 amino acids with 8-12 amino acid overlaps, across ten domains of PLA2R.
Xiao-Dan, Zhang +10 more
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Crystal structure of the CTLD7 domain of human M-type phospholipase A2 receptor
Journal of Structural Biology, 2019M-type phospholipase A2 receptor (PLA2R) is a member of the mannose receptor family. Recent evidence shows that PLA2R is a major autoantigen causing idiopathic membranous nephropathy (IMN), which is an autoimmune disease and one of the most common causes for nephrotic syndrome in adults. The epitope mapping data suggest that the major epitopes of PLA2R
Bowen Yu +4 more
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Antibodies to m‐type phospholipase
AbstractIdiopathic membranous nephropathy (IMN), the commonest cause of adult nephrotic syndrome (NS), accounts for only a minority of paediatric NS. Antibodies to m‐type phospholipase A2 receptor (PLA2R) are seen in two‐thirds of adult IMN cases.
Vinod, Kumar +8 more
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