Landscape of N1‐methyladenosin (m1A) modification pattern in colorectal cancer [PDF]
Cancer Reports, 2023 Background N1‐methyladenosine (m1A) is a recently identified mRNA modification. However, it is still unclear that how m1A alteration affects the development of colorectal cancer (CRC).
Chunhui Jiang +4 more
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Harnessing m1A modification: a new frontier in cancer immunotherapy [PDF]
Frontiers in ImmunologyN1-methyladenosine (m1A) modification is an epigenetic change that occurs on RNA molecules, regulated by a suite of enzymes including methyltransferases (writers), demethylases (erasers), and m1A-recognizing proteins (readers).
Xinru Wang +10 more
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The landscape of m1A modification and its posttranscriptional regulatory functions in primary neurons [PDF]
eLife, 2023 Cerebral ischaemia‒reperfusion injury (IRI), during which neurons undergo oxygen-glucose deprivation/reoxygenation (OGD/R), is a notable pathological process in many neurological diseases.
Chi Zhang +15 more
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Abundant mRNA m1A modification in dinoflagellates: a new layer of gene regulation [PDF]
EMBO ReportsDinoflagellates, a class of unicellular eukaryotic phytoplankton, exhibit minimal transcriptional regulation, representing a unique model for exploring gene expression.
Chongping Li +10 more
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Association of genetic variants in m1A modification core genes and neuroblastoma risk [PDF]
BMC CancerNeuroblastoma tightly linked with genetic abnormality. The core genes responsible for RNA N1-methyladenosine (m1A) modification are critical in tumor development. Nevertheless, few reports revealed the function of m1A modification core gene polymorphisms
Susu Jiang +16 more
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The landscape of N1-methyladenosine (m1A) modification in mRNA of the decidua in severe preeclampsia [PDF]
Biomolecules & BiomedicineRecent discoveries in mRNA modification have highlighted N1-methyladenosine (m1A), but its role in preeclampsia (PE) pathogenesis remains unclear. In this study, we utilized methylated RNA immunoprecipitation sequencing (MeRIP-seq) and RNA sequencing ...
Jing Tong +3 more
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m1A methylation modification patterns and metabolic characteristics in hepatocellular carcinoma [PDF]
BMC Gastroenterology, 2022 Background The dysregulation of RNA methylation has been demonstrated to contribute to tumorigenicity and progression in recent years. However, the alteration of N1-methyladenosine (m1A) methylation and its role in hepatocellular carcinoma (HCC) remain ...
Chengcheng Tong, Wei Wang, Chiyi He
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m1A Post‐Transcriptional Modification in tRNAs [PDF]
Biomolecules, 2017 To date, about 90 post‐transcriptional modifications have been reported in tRNA expanding their chemical and functional diversity. Methylation is the most frequent post‐transcriptional tRNA modification that can occur on almost all nitrogen sites of
Stephanie Oerum +3 more
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Reversible RNA Modification N1-methyladenosine (m1A) in mRNA and tRNA
Genomics, Proteomics & Bioinformatics, 2018 More than 100 modifications have been found in RNA. Analogous to epigenetic DNA methylation, epitranscriptomic modifications can be written, read, and erased by a complex network of proteins.
Chi Zhang, Guifang Jia
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tRNA m1A modification regulates cholesterol biosynthesis to promote antitumor immunity of CD8+ T cells. [PDF]
J Exp MedActivation of CD8+ T cells necessitates rapid metabolic reprogramming to fulfill the substantial biosynthetic demands of effector functions. However, the posttranscriptional mechanisms underpinning this process remain obscure. The transfer RNA (tRNA) N1-methyladenine (m1A) modification, essential for tRNA stability and protein translation, has an ...
Miao S +8 more
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