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Methyladenine as a regulator of biomolecular condensation [PDF]
Frontiers in Molecular BiosciencesRibonucleotide modifications modulate RNA structure and stability, thereby influencing RNA turnover and a wide range of cellular functions. Recent studies have revealed that specific RNA modifications can also affect the formation, composition, and ...
Roberto Arsiè +2 more
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N1-methyladenosine modification in cancer biology: Current status and future perspectives
Computational and Structural Biotechnology Journal, 2022 Post-transcriptional modifications in RNAs regulate their biological behaviors and functions. N1-methyladenosine (m1A), which is dynamically regulated by writers, erasers and readers, has been found as a reversible modification in tRNA, mRNA, rRNA and ...
Jiexin Li +2 more
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N 1-methyladenosine (m1A) RNA modification: the key to ribosome control [PDF]
The Journal of Biochemistry, 2020 AbstractRNA displays diverse functions in living cells. The presence of various chemical modifications of RNA mediated by enzymes is one of the factors that impart such functional diversity to RNA. Among more than 100 types of RNA modification, N1-methyladenosine (m1A) is found mainly in tRNA and rRNA of many living organisms and is known to be deeply ...
Kazuhiko Igarashi, Hiroki Shima
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Frontiers in Immunology, 2021 Backgroundrecently, many researches have concentrated on the relevance between N1-methyladenosine (m1A) methylation modifications and tumor progression and prognosis.
Jinhui Liu +6 more
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m1A RNA Modification in Gene Expression Regulation
Genes, 2022 N1-methyladenosine (m1A) is a prevalent and reversible post-transcriptional RNA modification that decorates tRNA, rRNA and mRNA. Recent studies based on technical advances in analytical chemistry and high-throughput sequencing methods have revealed the crucial roles of m1A RNA modification in gene regulation and biological processes. In this review, we
Hao Jin +3 more
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m1A and m6A modifications function cooperatively to facilitate rapid mRNA degradation
Cell Reports, 2022 N6-Methyladenosine (m6A), the most abundant internal mRNA modification, affects multiple steps in gene expression. Mechanistically, the binding of YTHDF2 to m6A on mRNAs elicits rapid mRNA degradation by recruiting several RNA degrading enzymes. Here, we show that N1-methyladenosine (m1A), another type of RNA modification, accelerates rapid m6A RNA ...
Sung Ho Boo, Hongseok Ha, Yoon Ki Kim
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Cell Death Discovery, 2023 N1-Methyladenosine (m1A) is an abundant modification of transcripts, plays important roles in regulating mRNA structure and translation efficiency, and is dynamically regulated under stress.
Zhangyang Qi +12 more
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Frontiers in Oncology, 2022 BackgroundPrevious studies have demonstrated that transcriptional RNA methyladenosine modification significantly affects tumor initiation and progression.
Guangyao Bao +6 more
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Frontiers in Immunology, 2022 RNA methylation plays crucial roles in gene expression and has been indicated to be involved in tumorigenesis, while it is still unclear whether m1A modifications have potential roles in the prognosis of hepatocellular carcinoma (HCC).
Mingxing Zhao +4 more
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