Results 151 to 160 of about 755,261 (255)

Estrogen Promotes Melanogenesis Through Facilitating M2 Macrophage Skewing in Melasma. [PDF]

Int J Mol Sci
Lin S, Su L, Deng Y, Qu Y, Shen D, Yao K, Wang Q, Ouyang M, Xu Q.   +8 more
europepmc   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Muscularis EGR1 Deficiency Impairs M2 Macrophage Polarization and Disrupts Gastric Motility in Diabetic Gastroparesis. [PDF]

Neurogastroenterol Motil
Xie N, Su G, Wu Y, Peng K, Mei Z, Chen W, Xu K, Li B.   +7 more
europepmc   +1 more source

Miro1 Protects Against Acute Kidney Injury Through Modulating Mitochondrial Homeostasis via Interaction With Sirt6

Advanced Science, EarlyView.
Ischemia‐reperfusion reduces Sirt6 activity, thereby increasing Miro1 acetylation. Hyperacetylated Miro1 exhibits perinuclear distribution and degradation, thereby inducing mitochondrial dysfunction and promoting apoptosis in renal tubular epithelial cells. This pathway reveals a mechanistic link between Sirt6‐mediated deacetylation and Miro1 stability
Lin Wu, Qing Li, Yiyang Xu, Zitao Wang, Hua Shu, Yangfan Wu, Fang Lu, Zhimin Huang, Bo Zhang, Hongwei Liang, Changying Xing, Huijuan Mao, Yanggang Yuan   +12 more
wiley   +1 more source

M2 macrophage-associated factors for constructing a prognostic model for osteosarcoma. [PDF]

Medicine (Baltimore)
Han J.
europepmc   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Metabolic reprogramming of glutamine is associated with M2 macrophage polarization in allergic rhinitis. [PDF]

Front Immunol
Yan S, Xue K, Wang Y, Jia D, Chen Y, Lai X, Zhao C, Chen G, Xu Y, Wang X, Pan H, Zeng N.   +11 more
europepmc   +1 more source

The demand for M2, opportunity cost, and financial change [PDF]

An analysis of the recent weakness in M2 growth that attempts to measure the opportunity cost of the aggregate more accurately and that explores the potential effects of the thrift industry restructuring on the adjustment of money demand to its long-run ...
John B. Carlson, Sharon E. Parrott
core  

Hypomethylation of GNA15 Promotes Pancreatic Ductal Adenocarcinoma Progression and Macrophage M2 Polarization via STAT3‐CXCL8 Axis

Advanced Science, EarlyView.
A schematic model summarizing GNA15's mechanism in mediating macrophage M2 polarization and Gemcitabine resistance. ABSTRACT The complexity of pancreatic ductal adenocarcinoma (PDAC) progression, coupled with the lack of effective immunotherapy, underscores the imperative to deepen our understanding of its mechanisms and identify suitable immune ...
Weihui Guo, Zhenyuan Qian, Lei Wang, Weilang Xu, Yuxin Weng, Kai Jiang, Zaiyuan Ye, Ji Xu, Guangyuan Song   +8 more
wiley   +1 more source

The anti‑inflammatory activity of 2‑iminothiazolidines: the role of PPARγ and M2 macrophage subpopulations. [PDF]

Inflammopharmacology
Mohr ETB, Lubschinski TL, Moro PAM, Benvenutti L, Costa NTC, de Sousa PLPB, Sá MM, Hernandes MZ, Milton FA, Santin JR, Dalmarco EM.   +10 more
europepmc   +1 more source