Results 111 to 120 of about 879,513 (265)

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source

Near‐Infrared Light‐Activated Polydopamine Nanoparticles Conjugated With Transferrin Peptides for Enhanced Brain Accumulation

Advanced Healthcare Materials, EarlyView.
This study demonstrates that Tf‐PDA NPs combine a receptor‐mediated targeting with mild photothermal activation to enhance nanoparticle accumulation in the brain. NIR‐activated Tf‐PDA NPs increase BBB permeability to NPs in vitro and in vivo without inducing cytotoxicity or adverse immune responses.
Rafaela Ferrão, Susana Simões, Paulo Rodrigues‐Santos, Vitor Francisco, Akhilesh Rai, Lino Ferreira   +5 more
wiley   +1 more source

Forecasting M2 growth: an exploration in real time [PDF]

Evan Koenig presents a model that has proved successful at reproducing the pattern of M2 growth over the first half of the decade of the 1990s. The model suggests that a large gap between long-term bond yields and M2 deposit rates contributed importantly
Evan F. Koenig
core  

Unprimed, M1 and M2 Macrophages Differentially Interact with Porphyromonas gingivalis. [PDF]

, 2016
Porphyromonas gingivalis is a keystone pathogen in the development of chronic periodontitis. Tissue macrophages are amongst the first immune cells to respond to bacteria and depending on the cytokine profile at the infection site, macrophages are primed ...
O'Brien-Simpson, NM, Roselind S Lam, Lenzo, JC, Jason C Lenzo, Shao B Fong, Reynolds, EC, James A Holden, Lam, RS, Neil M O'Brien-Simpson, Eric C Reynolds, Holden, JA, Fong, SB   +11 more
core   +2 more sources

Computed Tomography‐ and Photoacoustic Imaging‐Active Bioresorbable Electrospun Bismuth Nanoparticle‐Infused Small‐Diameter Vascular Grafts

Advanced Healthcare Materials, EarlyView.
A polymeric graft loaded with radiopaque bismuth nanoparticles is expected to undergo gradual polymer resorption and nanoparticle release. This design enables noninvasive, multimodal monitoring of device integrity, patency, and degradation using computed tomography alongside ultrasound and photoacoustic imaging over 12 weeks.
Allan John R. Barcena, Joy Vanessa D. Perez, Marvin R. Bernardino, Dominic Karl M. Bolinas, Kitz Paul D. Marco, Kim Claudette J. Fernandez, Archana Mishra, Erin Marie D. San Valentin, Jossana A. Damasco, Gino Martin Canlas, Natalie Fowlkes, Richard R. Bouchard, Steven Y. Huang, Marites P. Melancon   +13 more
wiley   +1 more source

Identification of M1 and M2 macrophages.

, 2019
Panel (a). Murine bone marrow-derived macrophages were analyzed by flow cytometry using antibodies against F4/80 and CD11b. F4/80+/CD11b+ cells are analyzed as macrophages. Panel (b).
Jung-Hwa Ryu (512365), Mengyuan Ge (6611972), Maarten Hoek (6611984), Koji Okamoto (640313), Hila Roshanravan (6611981), Alessia Fornoni (519467), Sandra Merscher (6611975), Myung K. Shin (288496), Avi Z. Rosenberg (632626), Marco Desante (6611978), Jeffrey B. Kopp (217081)   +10 more
core   +1 more source

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

The macrophages in rheumatic diseases

, 2016
Antonella Laria, Alfredomaria Lurati , Mariagrazia Marrazza , Daniela Mazzocchi, Katia Angela Re, Magda Scarpellini Rheumatology Unit, Fornaroli Hospital, Magenta, Italy Abstract: Macrophages belong to the innate immune system giving us protection ...
Laria A, Mazzocchi D, Re KA, Scarpellini M, Lurati A, Marrazza M   +5 more
core  

rFgl2-treated CD32b+M2 macrophages effectively inhibits cardiac transplant rejection in mice

Immunobiology
Background: The search for additional therapies against acute rejection is warranted. Alternatively activated macrophages (M2 macrophages) have immunomodulatory functions, and enhancement of their immunomodulatory capacity is a feasible complementary ...
Wenbin Ji, Baotong Zhang, Jiansheng Zhang, Guoshan Chen, Weiwei Wang, Feng Qi   +5 more
doaj   +1 more source

Effect of colorectal cancer-derived extracellular vesicles on the immunophenotype and cytokine secretion profile of monocytes and macrophages

Cell Communication and Signaling, 2018
. Background Macrophages are one of the most important players in the tumor microenvironment. The polarization status of tumor associated macrophages into a pro-inflammatory type M1 or anti-inflammatory type M2 may influence cancer progression and ...
Ineta Popēna, Artūrs Ābols, Līga Saulīte, Kārlis Pleiko, Elīna Zandberga, Kaspars Jēkabsons, Edgars Endzeliņš, Alicia Llorente, Aija Linē, Una Riekstiņa   +9 more
doaj   +1 more source