Results 51 to 60 of about 879,513 (265)

Distinct alterations of CD68+CD163+ M2-like macrophages and myeloid-derived suppressor cells in newly diagnosed primary immune thrombocytopenia with or without CR after high-dose dexamethasone treatment

Journal of Translational Medicine, 2018
Background Although impaired myeloid-derived suppressor cells (MDSCs) recently have been studied in immune thrombocytopenia (ITP), another myeloid-derived cell population signified as M2 macrophages has not been investigated properly in ITP patients.
Xia Shao, Boting Wu, Luya Cheng, Feng Li, Yanxia Zhan, Chanjuan Liu, Lili Ji, Zhihui Min, Yang Ke, Lihua Sun, Hao Chen, Yunfeng Cheng   +11 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

M1 and M2 Macrophages Polarization_Aravind Reddy Tarugu.jpg

, 2022
   Macrophage polarization is essential for tissue repair and homeostasis. It is a process by which macrophages generate divergent functional phenotypes in response to precise microenvironmental signals and stimuli.
Aravind Reddy Tarugu (13107756)
core   +1 more source

Immunological characteristics and functions of macrophages in Mycobacterium leprae infection

BMC Immunology
Objective Our research aimed to clarify the roles of M1 and M2 macrophages in leprosy, focusing on their polarization states, phagocytic capacities, and the survival of M. leprae within these macrophage subsets.
Xiaodong Zhang, Haiqin Jiang, Weijun Liu, Hongsheng Wang   +3 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Mast cells and M2 macrophages in ovarian cancer

, 2022
The objectives of this study were to investigate the immunohistochemical expression of markers of mast cells and M2 macrophages in benign and malignant ovarian neoplasms and to examine the prognostic value of this expression in ovarian cancer.
Eddie Fernando Candido Murta, Millena Prata Jammal, Rosekeila Simões Nomelini, Renata Margarida Etchebehere, Ananda Domingues Lopes   +4 more
core   +1 more source

β-elemene inhibits tumor-promoting in small cell lung cancer by affecting M2 macrophages and TGF-β

BMC Pulmonary Medicine
Objective M2 macrophages have been implicated in promoting tumor growth and metastasis in various cancers, including small cell lung cancer (SCLC).
Wenhui Huang, Bing Fu, Haoran Xu
doaj   +1 more source

M2-polarized macrophages promote metastatic behavior of Lewis lung carcinoma cells by inducing vascular endothelial growth factor-C expression

Clinics, 2012
OBJECTIVES: Tumor-associated macrophages that generally exhibit an alternatively activated (M2) phenotype have been linked to tumor progression and metastasis.
Bicheng Zhang, Yafei Zhang, Guoqing Yao, Juan Gao, Bo Yang, Yong Zhao, Zhiguo Rao, Jianfei Gao   +7 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Effects of montelukast on M2-related cytokine and chemokine in M2 macrophages [PDF]

, 2016
Background/PurposeAsthma is a chronic airway inflammatory disease mediated by T-helper (Th)2 cells. Montelukast (trade name Singulair) is a cysteinyl leukotriene receptor antagonist used for asthma treatment.
Kuo, Hsuan-Fu, Lin, Yi-Ching, Hung, Chih-Hsing, Lee, Min-Sheng, Hsieh, Chong-Chao, Huang, Ming-Yii, Kuo, Chang-Hung   +6 more
core   +2 more sources