Results 41 to 50 of about 879,513 (265)

M2 macrophage infusion ameliorates diabetic glomerulopathy via the JAK2/STAT3 pathway in db/db mice

Renal Failure
Objectives: To explore the therapeutic effects of M2 macrophages in diabetic nephropathy (DN) and their mechanism.Methods: We infused M2 macrophages stimulated with IL-4 into 10-week-old db/db mice once a week for 4 weeks through the tail vein as M2 ...
Yulin Gu, Songyan Yu, Weijun Gu, Bing Li, Jing Xue, Jiejie Liu, Qi Zhang, Yaqi Yin, Haixia Zhang, Qinghua Guo, Mingxia Yuan, Zhaohui Lyu, Yiming Mu, Yu Cheng   +13 more
doaj   +1 more source

Clec7a expression in inflammatory macrophages orchestrates progression of acute kidney injury

Frontiers in Immunology, 2022
Acute kidney injury (AKI) is associated with high risk of mortality, post-disease renal fibrosis, kidney dysfunction and renal failure. Renal macrophages play a key role in the pathogenesis (M1 subpopulation), healing and remodeling (M2 subpopulation) in
Yaqiong Wang, Yaqiong Wang, Yaqiong Wang, Yaqiong Wang, Yaqiong Wang, Xianzhe Li, Xianzhe Li, Xianzhe Li, Xianzhe Li, Xianzhe Li, Xialian Xu, Xialian Xu, Xialian Xu, Xialian Xu, Xialian Xu, Jinbo Yu, Jinbo Yu, Jinbo Yu, Jinbo Yu, Jinbo Yu, Xiaohong Chen, Xiaohong Chen, Xiaohong Chen, Xiaohong Chen, Xiaohong Chen, Xuesen Cao, Xuesen Cao, Xuesen Cao, Xuesen Cao, Xuesen Cao, Jianzhou Zou, Jianzhou Zou, Jianzhou Zou, Jianzhou Zou, Jianzhou Zou, Bo Shen, Bo Shen, Bo Shen, Bo Shen, Bo Shen, Xiaoqiang Ding, Xiaoqiang Ding, Xiaoqiang Ding, Xiaoqiang Ding, Xiaoqiang Ding   +44 more
doaj   +1 more source

M2-like macrophages transplantation protects against the doxorubicin-induced heart failure via mitochondrial transfer

Biomaterials Research, 2022
Aims The alternatively activated macrophages have shown a cardioprotective effect in heart failure. However, the effect of M2 adoptive transfer in non-ischemic heart failure is unknown.
Yihai Liu, Mingyue Wu, Chongxia Zhong, Biao Xu, Lina Kang   +4 more
doaj   +1 more source

M2 macrophage polarization: a potential target in pain relief

Frontiers in Immunology, 2023
Pain imposes a significant urden on patients, affecting them physically, psychologically, and economically. Despite numerous studies on the pathogenesis of pain, its clinical management remains suboptimal, leading to the under-treatment of many pain ...
Wenjing Zhao, Wenjing Zhao, Wenjing Zhao, Lulin Ma, Lulin Ma, Lulin Ma, Daling Deng, Daling Deng, Daling Deng, Tianhao Zhang, Tianhao Zhang, Tianhao Zhang, Linlin Han, Linlin Han, Linlin Han, Feng Xu, Feng Xu, Feng Xu, Shiqian Huang, Shiqian Huang, Shiqian Huang, Yuanyuan Ding, Yuanyuan Ding, Yuanyuan Ding, Xiangdong Chen, Xiangdong Chen, Xiangdong Chen   +26 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

miR-181a Induces Macrophage Polarized to M2 Phenotype and Promotes M2 Macrophage-mediated Tumor Cell Metastasis by Targeting KLF6 and C/EBPα

Molecular Therapy: Nucleic Acids, 2016
Macrophages can acquire a variety of polarization status and functions: classically activated macrophages (M1 macrophages); alternatively activated macrophages (M2 macrophages). However, the molecular basis of the process is still unclear.
Jia Bi, Xianxin Zeng, Lin Zhao, Qian Wei, Lifeng Yu, Xinnan Wang, Zhaojin Yu, Yaming Cao, Fengping Shan, Minjie Wei   +9 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Saikosaponin A affects differentiation and function of M1/M2 macrophages by regulating NF-κB and STAT6 signaling pathways

陆军军医大学学报
Objective To investigate the effect of Saikosaponin A (SSA) on the differentiation, apoptosis and function of mouse bone marrow derived macrophages (BMDM)-derived M1/M2 macrophages, and to explore its molecular mechanism.
CUI Zhao, SHU Yating, LEI Fan
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source