Results 31 to 40 of about 879,513 (265)

Roles of alternatively activated M2 macrophages in allergic contact dermatitis

Allergology International, 2017
Alternatively activated macrophages (M2 macrophages) play key roles in the suppression of Th1 cell responses and the orchestration of tissue repair.
Kotaro Suzuki, Kazuyuki Meguro, Daiki Nakagomi, Hiroshi Nakajima   +3 more
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M2 macrophages secrete CXCL13 to promote renal cell carcinoma migration, invasion, and EMT

Cancer Cell International, 2021
Objective M2 macrophages are associated with a poor prognosis in a variety of malignancies. There are, however, few relevant investigations in clear cell renal cell carcinoma (ccRCC).
Yingwei Xie, Zhiliang Chen, Qiyu Zhong, Zaosong Zheng, Yuqing Chen, Wentai Shangguan, Yishan Zhang, Jingying Yang, Dingjun Zhu, Wenlian Xie   +9 more
doaj   +1 more source

Stimulation of the farnesoid X receptor promotes M2 macrophage polarization

Frontiers in Immunology, 2023
FXR is a key molecule that modulates anti-inflammatory activity in the intestinal-liver axis. Although FXR has pleiotropic functions including regulation of liver inflammation and activation of macrophages, it remains unclear whether it is involved in ...
Thiranut Jaroonwitchawan, Hideki Arimochi, Yuki Sasaki, Chieko Ishifune, Hiroyuki Kondo, Kunihiro Otsuka, Kunihiro Otsuka, Shin-ichi Tsukumo, Shin-ichi Tsukumo, Koji Yasutomo, Koji Yasutomo, Koji Yasutomo   +11 more
doaj   +1 more source

Tissue transglutaminase exacerbates renal fibrosis via alternative activation of monocyte-derived macrophages

Cell Death and Disease, 2023
Macrophages are important components in modulating homeostatic and inflammatory responses and are generally categorized into two broad but distinct subsets: classical activated (M1) and alternatively activated (M2) depending on the microenvironment ...
Yoshiki Shinoda, Hideki Tatsukawa, Atsushi Yonaga, Ryosuke Wakita, Taishu Takeuchi, Tokuji Tsuji, Miyako Tanaka, Takayoshi Suganami, Kiyotaka Hitomi   +8 more
doaj   +1 more source

M2 Macrophage Co-Expression Factors Correlate With Immune Phenotype and Predict Prognosis of Bladder Cancer

Frontiers in Oncology, 2021
PurposeTherapeutic targets of tumor-associated macrophages have been discovered and used clinically as immunotherapy. M2 macrophages are tumor-associated macrophages that promote cancer progression.
Yutao Wang, Kexin Yan, Jianfeng Wang, Jiaxing Lin, Jianbin Bi   +4 more
doaj   +1 more source

M2-polarized tumor-associated macrophages facilitated migration and epithelial-mesenchymal transition of HCC cells via the TLR4/STAT3 signaling pathway

World Journal of Surgical Oncology, 2018
Background M2-polarized macrophages are tumor-associated-macrophages (TAMs), which are important contents of tumor-infiltrating immune cells. Toll-like receptor 4 (TLR4) is a molecular biomarker of tumor aggressiveness and poor prognosis.
Rong-Rong Yao, Jing-Huan Li, Rui Zhang, Rong-Xin Chen, Yan-Hong Wang   +4 more
doaj   +1 more source

Epigenetic therapy reprograms M2-type tumor-associated macrophages into an M1-like phenotype by upregulating miR-7083-5p

Frontiers in Immunology, 2022
Reprogramming M2-type, pro-tumoral tumor-associated macrophages (TAMs) into M1-type, anti-tumoral macrophages is a key strategy in cancer therapy. In this study, we exploited epigenetic therapy using the DNA methylation inhibitor 5-aza-2’-deoxycytidine ...
Sri Murugan Poongkavithai Vadevoo, Sri Murugan Poongkavithai Vadevoo, Gowri Rangaswamy Gunassekaran, Gowri Rangaswamy Gunassekaran, Jae Do Yoo, Jae Do Yoo, Tae-Hwan Kwon, Tae-Hwan Kwon, Tae-Hwan Kwon, Keun Hur, Keun Hur, Keun Hur, Sehyun Chae, Byungheon Lee, Byungheon Lee, Byungheon Lee   +15 more
doaj   +1 more source

M2‐like macrophages serve as a niche for adipocyte progenitors in adipose tissue

Journal of Diabetes Investigation, 2019
Adipose tissue (AT) is composed not only of adipocytes, but also of macrophages, endothelial cells and preadipocytes. Macrophages are an important component of AT, and are involved in tissue homeostasis, tissue repair and fibrosis.
Allah Nawaz, Kazuyuki Tobe
doaj   +1 more source

Distribution of M1 and M2 macrophages in tumor islets and stroma in relation to prognosis of non-small cell lung cancer

BMC Immunology, 2018
Background Non-small cell lung cancer (NSCLC) remains the most common cause of cancer related death worldwide. Tumor-infiltrating macrophages are believed to play an important role in growth, progression, and metastasis of tumors.
Jurgita Jackute, Marius Zemaitis, Darius Pranys, Brigita Sitkauskiene, Skaidrius Miliauskas, Simona Vaitkiene, Raimundas Sakalauskas   +6 more
doaj   +1 more source

YY1 complex in M2 macrophage promotes prostate cancer progression by upregulating IL-6

Journal for ImmunoTherapy of Cancer, 2023
Background Tumor-associated macrophages are mainly polarized into the M2 phenotype, remodeling the tumor microenvironment and promoting tumor progression by secreting various cytokines.Methods Tissue microarray consisting of prostate cancer (PCa), normal
Lihua Zhang, Ming Chen, Shenghong Ju, Kai Lu, Bin Xu, Wenchao Li, Saisai Chen, Jianping Wu, Yue Hou, Zonghao You, Chuanjun Shu, Xiaoying Wei, Tiange Wu, Naipeng Shi, Guangyuan Zhang, Shuqiu Chen, Dingxiao Zhang   +16 more
doaj   +1 more source