Results 1 to 10 of about 63,662 (384)

The role of m6A modification in the biological functions and diseases

Signal Transduction and Targeted Therapy, 2021
N 6 -methyladenosine (m6A) is the most prevalent, abundant and conserved internal cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells.
Xiulin Jiang, Baiyang Liu, Zhi Nie, Lincan Duan, Qiu-xia Xiong, Zhixian Jin, Cuiping Yang, Yongbin Chen   +7 more
semanticscholar   +1 more source

Adaptive Syllable Training Improves Phoneme Identification in Older Listeners with and without Hearing Loss

Audiology Research, 2022
Acoustic-phonetic speech training mitigates confusion between consonants and improves phoneme identification in noise. A novel training paradigm addressed two principles of perceptual learning.
Annette Schumann, Bernhard Ross
doaj   +1 more source

METTL3 Affects Spinal Cord Neuronal Apoptosis by Regulating Bcl-2 m6A Modifications After Spinal Cord Injury [PDF]

Neurospine, 2023
Objective Spinal cord injury (SCI) is a severe type of neurological trauma. N6-methyladenosine (m6A) modification is one of the most common internal modifications of RNA.
Shengyu Guo, Taotao Lin, Gang Chen, Zhitao Shangguan, Linquan Zhou, Zhi Chen, Tengbin Shi, Dehui Chen, Zhenyu Wang, Wenge Liu   +9 more
doaj   +1 more source

The role of m6A RNA methylation in cancer metabolism

Molecular Cancer, 2022
Metabolic reprogramming is one of the main characteristics of malignant tumors, which is due to the flexible changes of cell metabolism that can meet the needs of cell growth and maintain the homeostasis of tissue environments.
Yuanyuan An, Huayan Duan
semanticscholar   +1 more source

m6A modification: recent advances, anticancer targeted drug discovery and beyond

Molecular Cancer, 2022
Abnormal N6-methyladenosine (m6A) modification is closely associated with the occurrence, development, progression and prognosis of cancer, and aberrant m6A regulators have been identified as novel anticancer drug targets.
Lijuan Deng, Weilun Deng, Shunming Fan, Minfeng Chen, Ming Qi, Wen-Yu Lyu, Qi Qi, A. Tiwari, Jia-xu Chen, Dong-Mei Zhang, Zhe‐Sheng Chen   +10 more
semanticscholar   +1 more source

MiR-141-3p promotes malignant progression in prostate cancer through AlkB homolog 5-mediated m6A modification of protein arginine methyltransferase 6

Chinese Journal of Physiology, 2023
Prostate cancer (PCa) is one of the leading causes of cancer-related death in males worldwide and exploring more reliable biomarkers for PCa is essential for the diagnosis and therapeutics for the disease.
Xun Li, Bide Liu, Shuheng Wang, Jiuzhi Li, Xiaohu Ge   +4 more
doaj   +1 more source

N⁶-Methyladenosine (m⁶A) Methylation-Mediated Transcriptional Regulation in Maize Root Response to Salt Stress. [PDF]

Plants (Basel)
Ta W, Zhuang Z, Bian J, Ren Z, Hao X, Zhang L, Peng Y.   +6 more
europepmc   +3 more sources

RNA N6-Methyladenosine Regulators Contribute to Tumor Immune Microenvironment and Have Clinical Prognostic Impact in Breast Cancer

Frontiers in Genetics, 2022
Purpose: This study aims to reveal the relationship between RNA N6-methyladenosine (m6A) regulators and tumor immune microenvironment (TME) in breast cancer, and to establish a risk model for predicting the occurrence and development of tumors.Patients ...
Lan-Xin Mu, You-Cheng Shao, Lei Wei, Fang-Fang Chen, Jing-Wei Zhang   +4 more
doaj   +1 more source

Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma

Genome Biology, 2021
Background Histone lactylation, a metabolic stress-related histone modification, plays an important role in the regulation of gene expression during M1 macrophage polarization.
Jie Yu, P. Chai, Minyue Xie, S. Ge, Jing Ruan, Xianqun Fan, Renbing Jia   +6 more
semanticscholar   +1 more source

RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming

Nature Communications, 2021
N6-methyladenosine (m6A) is a reversible mRNA modification that has been shown to play important roles in various biological processes. However, the roles of m6A modification in macrophages are still unknown.
Huilong Yin, Xiang Zhang, Pengyuan Yang, Xiaofang Zhang, Yingran Peng, D. Li, Yanping Yu, Ye Wu, Yidi Wang, Jinbao Zhang, Xiaochen Ding, Xiangpeng Wang, A. Yang, Rui Zhang   +13 more
semanticscholar   +1 more source