Results 1 to 10 of about 58,783 (322)

RNA m6A methylation across the transcriptome.

Molecular Cell, 2023
Since the early days of foundational studies of nucleic acids, many chemical moieties have been discovered to decorate RNA and DNA in diverse organisms.
Erdem Sendinc, Yang Shi
semanticscholar   +3 more sources

The role of m6A modification in the biological functions and diseases

Signal Transduction and Targeted Therapy, 2021
N 6 -methyladenosine (m6A) is the most prevalent, abundant and conserved internal cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells.
Xiulin Jiang, Baiyang Liu, Zhi Nie, Lincan Duan, Qiu-xia Xiong, Zhixian Jin, Cuiping Yang, Yongbin Chen   +7 more
semanticscholar   +1 more source

Adaptive Syllable Training Improves Phoneme Identification in Older Listeners with and without Hearing Loss

Audiology Research, 2022
Acoustic-phonetic speech training mitigates confusion between consonants and improves phoneme identification in noise. A novel training paradigm addressed two principles of perceptual learning.
Annette Schumann, Bernhard Ross
doaj   +1 more source

METTL3 Affects Spinal Cord Neuronal Apoptosis by Regulating Bcl-2 m6A Modifications After Spinal Cord Injury [PDF]

Neurospine, 2023
Objective Spinal cord injury (SCI) is a severe type of neurological trauma. N6-methyladenosine (m6A) modification is one of the most common internal modifications of RNA.
Shengyu Guo, Taotao Lin, Gang Chen, Zhitao Shangguan, Linquan Zhou, Zhi Chen, Tengbin Shi, Dehui Chen, Zhenyu Wang, Wenge Liu   +9 more
doaj   +1 more source

Reading m6A in the Transcriptome: m6A-Binding Proteins [PDF]

Trends in Cell Biology, 2018
N6-Methyladenosine (m6A) is the most prevalent post-transcriptional modification of eukaryotic mRNA and long noncoding RNA. m6A mediates its effects primarily by recruiting proteins, including the multiprotein eukaryotic initiation factor 3 complex and a set of proteins that contain the YTH domain.
Deepak P, Patil, Brian F, Pickering, Samie R, Jaffrey   +2 more
openaire   +2 more sources

MiR-141-3p promotes malignant progression in prostate cancer through AlkB homolog 5-mediated m6A modification of protein arginine methyltransferase 6

Chinese Journal of Physiology, 2023
Prostate cancer (PCa) is one of the leading causes of cancer-related death in males worldwide and exploring more reliable biomarkers for PCa is essential for the diagnosis and therapeutics for the disease.
Xun Li, Bide Liu, Shuheng Wang, Jiuzhi Li, Xiaohu Ge   +4 more
doaj   +1 more source

Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells.

Molecules and Cells, 2022
Tumor-infiltrating myeloid cells (TIMs) are crucial cell populations involved in tumor immune escape, and their functions are regulated by multiple epigenetic mechanisms.
Jia Xiong, Jia He, Jun Zhu, Jiongli Pan, Weijie Liao, Hongying Ye, Hao Wang, Yinjing Song, Yue Du, Bijun Cui, Maoguang Xue, Wanling Zheng, Xiangxing Kong, K. Jiang, K. Ding, Lihua Lai, Qingqing Wang   +16 more
semanticscholar   +1 more source

Transcriptome-Wide m6A Methylome and m6A-Modified Gene Analysis in Asthma

Frontiers in Cell and Developmental Biology, 2022
N6-methyladenosine (m6A) modification is one of the most prevalent RNA modification forms and is an important posttranscriptional mechanism for regulating genes. In previous research, we found that m6A regulator–mediated RNA methylation modification was involved in asthma; however, the specific modified genes are not clear.
Deyang Sun, Xiaolu Cai, Fenglin Shen, Liming Fan, Huan Yang, Suqun Zheng, Linshui Zhou, Ke Chen, Zhen Wang, Zhen Wang   +9 more
openaire   +3 more sources

RNA N6-Methyladenosine Regulators Contribute to Tumor Immune Microenvironment and Have Clinical Prognostic Impact in Breast Cancer

Frontiers in Genetics, 2022
Purpose: This study aims to reveal the relationship between RNA N6-methyladenosine (m6A) regulators and tumor immune microenvironment (TME) in breast cancer, and to establish a risk model for predicting the occurrence and development of tumors.Patients ...
Lan-Xin Mu, You-Cheng Shao, Lei Wei, Fang-Fang Chen, Jing-Wei Zhang   +4 more
doaj   +1 more source

The role of m6A RNA methylation in cancer metabolism

Molecular Cancer, 2022
Metabolic reprogramming is one of the main characteristics of malignant tumors, which is due to the flexible changes of cell metabolism that can meet the needs of cell growth and maintain the homeostasis of tissue environments.
Yuanyuan An, Huayan Duan
semanticscholar   +1 more source