Results 91 to 100 of about 63,662 (384)

RNA m6A modification, signals for degradation or stabilisation?

Biochemical Society Transactions
The RNA modification N6-methyladenosine (m6A) is conserved across eukaryotes, and profoundly influences RNA metabolism, including regulating RNA stability. METTL3 and METTL14, together with several accessory components, form a ‘writer’ complex catalysing
Guifeng Wei
semanticscholar   +1 more source

RNA m6A methylation modulates airway inflammation in allergic asthma via PTX3-dependent macrophage homeostasis

Nature Communications, 2023
N6-methyladenosine (m6A), the most prevalent mRNA modification, has an important function in diverse biological processes. However, the involvement of m6A in allergic asthma and macrophage homeostasis remains largely unknown.
Xiao Han, Lijuan Liu, Saihua Huang, Wenfeng Xiao, Yajing Gao, Weitao Zhou, Caiyan Zhang, Hongmei Zheng, Lan Yang, Xueru Xie, Qiuyan Liang, Zikun Tu, Hongmiao Yu, Jinrong Fu, Libo Wang, Xiaobo Zhang, Liling Qian, Yufeng Zhou   +17 more
semanticscholar   +1 more source

Tendon Organoids Enable Functional Tendon Rejuvenation Through ALKBH5‐Dependent RNA Demethylation

Advanced Science, EarlyView.
FT organoids reverse the aged phenotype of tendon cells, reinstating a fetal‐like state. This breakthrough establishes a potent cell source for tendon tissue engineering, effectively advancing regenerative medicine. ABSTRACT Adult tendon injuries pose a major clinical challenge due to limited self‐repair capacity, resulting in suboptimal regeneration ...
Tian Qin, Aini Pan, Zhuoning Miao, Yanyan Zhao, Xianan Mo, Heng Sun, Chunmei Fan, Junyu Guo, Bingbing Wu, Weiliang Shen, Qiangqiang Zheng, Jun Lu, Xi Jiang, Zi Yin, Xiao Chen   +14 more
wiley   +1 more source

Crosstalk between RNA Metabolism and Cellular Stress Responses during Zika Virus Replication

Pathogens, 2020
Zika virus (ZIKV) is a mosquito-borne virus associated with neurological disorders such as Guillain-Barré syndrome and microcephaly. In humans, ZIKV is able to replicate in cell types from different tissues including placental cells, neurons, and ...
Aarón Oyarzún-Arrau, Luis Alonso-Palomares, Fernando Valiente-Echeverría, Fabiola Osorio, Ricardo Soto-Rifo   +4 more
doaj   +1 more source

Altered expression of neuroplasticity-related genes in the brain of depressed suicides [PDF]

, 2015
Background: Expression of the neuronal membrane glycoprotein M6a (GPM6A), the proteolipid protein (PLP/DM20) family member, is downregulated in the hippocampus of chronically stressed animals.
Alvarez Juliá, Anabel, Frasch, Alberto Carlos C., Fuchsova, Beata, Pandey, G. N., Rizavi, H. S.   +4 more
core   +1 more source

NAT10 mediated ac4C acetylation driven m6A modification via involvement of YTHDC1-LDHA/PFKM regulates glycolysis and promotes osteosarcoma

Cell Communication and Signaling
The dynamic changes of RNA N6-methyladenosine (m6A) during cancer progression participate in various cellular processes. However, less is known about a possible direct connection between upstream regulator and m6A modification, and therefore affects ...
Zhongting Mei, Zhihua Shen, Jiaying Pu, Qian Liu, Guoxin Liu, Xuting He, Yang Wang, Jinrui Yue, Shiyu Ge, Tao Li, Ye Yuan, Lei Yang   +11 more
semanticscholar   +1 more source

ALKBH5/YTHDF2‐mediated m6A modification of circAFF2 enhances radiosensitivity of colorectal cancer by inhibiting Cullin neddylation

Clinical and Translational Medicine, 2023
Background Circular RNA (circRNA) and N6‐methyladenosine (m6A) play a critical role in tumour occurrence and development, including colorectal cancer (CRC). However, little is known about the interaction between circRNA and m6A in the radiosensitivity of
Yingjie Shao, Zhenhua Liu, Xing Song, R. Sun, You Zhou, Dachuan Zhang, Huihui Sun, Junchao Huang, Chenxi Wu, Wendong Gu, Xiao Zheng, Jingting Jiang   +11 more
semanticscholar   +1 more source

Profiling Analysis of N6-Methyladenosine mRNA Methylation Reveals Differential m6A Patterns during the Embryonic Skeletal Muscle Development of Ducks [PDF]

, 2022
Biao Chen, Shuibing Liu, Wentao Zhang, Ting Xiong, Mingfang Zhou, Xiaolong Hu, Huirong Mao, Sanfeng Liu   +7 more
openalex   +1 more source

HPD is an m6A Methyltransferase that Protects Colorectal Cancer Cells from Ferroptotic Cell Death by m6A Methylating SLC7A11/GPX4

Advanced Science, EarlyView.
This study reveals that the tyrosine metabolic enzyme HPD functions as a previously uncharacterized, METTL3‐independent m6A methyltransferase. It promotes colorectal tumor progression by coordinately regulating the SLC7A11/GPX4 axis to suppress ferroptosis.
Jiyan Wang, Xintong Dai, Huanle Liu, Saiwei Hua, Hongkai Chang, Huanran Sun, Mingming Sun, Huifang Zhao, Kemin Ni, Fei Xie, Yaya Qiao, Qingle Gao, Chenxi Yu, Qijun Zhang, Jianshuang Guo, Chunze Zhang, Shuai Zhang, Changliang Shan   +17 more
wiley   +1 more source

Progress and application of epitranscriptomic m6A modification in gastric cancer

RNA Biology, 2022
The relationship between epitranscriptomics and malignant tumours has become a popular research topic in recent years. N6-methyladenosine (m6A), the most common post-transcriptional modification in mammals, is involved in various physiological processes ...
Yitian Xu, Chen Huang
doaj   +1 more source