Results 91 to 100 of about 58,783 (322)
The structure and function of YTHDF epitranscriptomic m6A readers.
TIPS - Trends in Pharmacological Sciences, 2023 Specific RNA sequences modified by a methylated adenosine, N6-methyladenosine (m6A), contribute to the post-transcriptional regulation of gene expression.
Vilbert Sikorski +4 more
semanticscholar +1 more source
Nonabelian Duality and Higgs Multiplets in Supersymmetric Grand Unified Theories [PDF]
, 1996 We consider strongly interacting supersymmetric gauge theories which break dynamically the GUT symmetry and produce the light Higgs doublets naturally.
Hotta, T., Izawa, K. -I., Yanagida, T.
core +2 more sources
Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System
Advanced Science, EarlyView.This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi +13 more
wiley +1 more source
Progress and application of epitranscriptomic m6A modification in gastric cancer
RNA Biology, 2022 The relationship between epitranscriptomics and malignant tumours has become a popular research topic in recent years. N6-methyladenosine (m6A), the most common post-transcriptional modification in mammals, is involved in various physiological processes ...
Yitian Xu, Chen Huang
doaj +1 more source
A Unified Model for the Function of YTHDF Proteins in Regulating m6A-Modified mRNA.
Cell, 2020 N6-methyladenosine (m6A) is the most abundant mRNA nucleotide modification and regulates critical aspects of cellular physiology and differentiation. m6A is thought to mediate its effects through a complex network of interactions between different m6A ...
S. Zaccara, S. Jaffrey
semanticscholar +1 more source
Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA. [PDF]
, 2019 N6-methyladenosine (m6A) modification provides an important epitranscriptomic mechanism that critically regulates RNA metabolism and function. However, how m6A writers attain substrate specificities remains unclear. We report the 3.1 Å-resolution crystal
Gao, Linfeng +6 more
core
Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation [PDF]
, 2017 Transcription and translation are two main pillars of gene expression. Due to the different timings, spots of action, and mechanisms of regulation, these processes are mainly regarded as distinct and generally uncoupled, despite serving a common purpose.
Agami, R. (Reuven) +6 more
core +4 more sources
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Cancer Management and Research, 2020 Li-chao Xu,1,2,* Jing-xin Pan,3,* Hong-da Pan2 1Department of Interventional Radiology, Fudan University Shanghai Cancer Center, Shanghai 200032, People’s Republic of China; 2Department of Oncology, Shanghai Medical College, Fudan University ...
Xu L, Pan J, Pan H
doaj
The potential regulatory role of RNA methylation in ovarian cancer
RNA Biology, 2023 Updates in whole genome sequencing technologies have revealed various RNA modifications in cancer, among which RNA methylation is a frequent posttranscriptional modification.
Shijie Zhao +5 more
doaj +1 more source