Results 101 to 110 of about 58,783 (322)
Gastroenterology, 2022 BACKGROUND & AIMS N6-Methyladenosine (m6A) is the most prevalent RNA modification and recognized as an important epitranscriptomic mechanism in colorectal cancer (CRC).
Huarong Chen +16 more
semanticscholar +1 more source
Cancellation of Infrared Divergence in Inclusive Production of Heavy Quarkonia
, 2016 A scheme is presented here to cancel out the topologically unfactorized infrared divergences in the inclusive production of heavy quarkonia, which affect the NRQCD factorization of these processes.
Zhou, Gao-Liang
core +1 more source
Current epigenetic aspects the clinical kidney researcher should embrace [PDF]
, 2017 Chronic kidney disease (CKD), affecting 10-12% of the world's adult population, is associated with a considerably elevated risk of serious comorbidities, in particular, premature vascular disease and death.
Ekström, Tomas J. +5 more
core +1 more source
Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells
Advanced Science, EarlyView.ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen +11 more
wiley +1 more source
Journal of Inflammation Research, 2023 Xiao Tong, Xinyi Zhao, Xuan Dang, Yan Kou, Junjie Kou Department of Cardiology, The 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, People’s Republic of ...
Tong X, Zhao X, Dang X, Kou Y, Kou J
doaj
Recent advances in dynamic m6A RNA modification [PDF]
Open Biology, 2016 The identification of m6A demethylases and high-throughput sequencing analysis of methylated transcriptome corroborated m6A RNA epigenetic modification as a dynamic regulation process, and reignited its investigation in the past few years.
Guangchao Cao +3 more
doaj +1 more source
FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development
Science, 2022 N6-methyladenosine (m6A) is the most abundant internal modification on mammalian messenger RNA. It is installed by a writer complex and can be reversed by erasers such as the fat mass and obesity-associated protein FTO.
Jiangbo Wei +33 more
semanticscholar +1 more source
The second moment of twisted modular L-functions
, 2014 We prove an asymptotic formula with a power saving error term for the (pure or mixed) second moment of central values of L-functions of any two (possibly equal) fixed cusp forms f, g twisted by all primitive characters modulo q, valid for all ...
Blomer, Valentin, Milićević, Djordje
core +1 more source
Pitting damage levels estimation for planetary gear sets based on model simulation and grey relational analysis [PDF]
, 2011 The planetary gearbox is a critical mechanism in helicopter transmission systems. Tooth failures in planetary gear sets will cause great risk to helicopter operations.
Cheng, Zhe +3 more
core +1 more source
Advanced Science, EarlyView.We identify an antagonistic ubiquitin circuit that controls cellular permissiveness to multiple coronaviruses. The deubiquitinase USP7 stabilizes the epigenetic regulator KDM6A to upregulate viral receptors, while the E3 ligase RNF40 degrades KDM6A by catalyzing K6/K11‐ubiquitin chains of KDM6A for autophagic degradation.
Meng‐Zhuo Huang +9 more
wiley +1 more source