Results 111 to 120 of about 58,783 (322)

Salsolinol as an RNA m6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

Neural Regeneration Research
Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, Sal) is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, an environmental toxin that causes Parkinson ...
Jianan Wang, Yuanyuan Ran, Zihan Li, Tianyuan Zhao, Fangfang Zhang, Juan Wang, Zongjian Liu, Xuechai Chen   +7 more
doaj   +1 more source

METTL3-mediated m6A modification of TIMP2 mRNA promotes podocyte injury in diabetic nephropathy

Molecular Therapy, 2022
Epigenetic changes are present in many physiological and pathological processes. The N6-methyladenosine (m6A) modification is the most common modification in eukaryotic mRNA.
Ling Jiang, Xue-Qi Liu, Xuelin Hu, Li Gao, Han-Xu Zeng, Xian Wang, Yue Huang, Wei Zhu, Jia-nan Wang, Jia-gen Wen, Xiao-ming Meng, Yong-gui Wu   +11 more
semanticscholar   +1 more source

Deciphering the epitranscriptome: a green perspective [PDF]

, 2016
The advent of high-throughput sequencing technologies coupled with new detection methods of RNA modifications has enabled investigation of a new layer of gene regulation - the epitranscriptome.
Burgess, A., David, R., Searle, I.
core   +1 more source

Hepatocyte BPGM Induces RET Lactylation and Macrophage Reprogramming to Promote Tumorigenesis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Mechanistic schematic diagram.BPGM promotes the expression level of RET by increasing the lactylation of RET‐K549 and inhibiting its ubiquitination levels in HCC cells. Furthermore, BPGM in HCC cells could also promote M2 polarization in macrophages through lactate secretion. Both of the mechanisms could promote the progression of HCC. ABSTRACT Aerobic
Jiajia Zhang, Lu Shi, Liangliang Lin, Yang Zhang, Miao Zhang, Lili Wu, Yong Xia, Yaqiong Zhang, Peng Han, Likun Zhuang, Liang Shi   +10 more
wiley   +1 more source

Link Between m6A Modification and Cancers [PDF]

Frontiers in Bioengineering and Biotechnology, 2018
N6-methyladenosine (m6A) epitranscriptional modification has recently gained much attention. Through the development of m6A sequencing, the molecular mechanism and importance of m6A have been revealed. m6A is the most abundant internal modification in higher eukaryotic mRNAs, which plays crucial roles in mRNA metabolism and multiple biological ...
Zhen-Xian Liu, Li-Man Li, Hui-Lung Sun, Song-Mei Liu   +3 more
openaire   +3 more sources

Star and protoplanetary disk properties in Orion's suburbs

, 2009
(Note: this is a shortened version of the original "structured" A&A format abstract.) We performed a large optical spectroscopic and photometric survey of the Lynds~1630N and 1641 clouds.
A. Carmona, A. Sicilia-Aguilar, Acke, Acke, Acke, Adams, Akeson, Akeson, Alcalá, Alexander, Allen, Alonso-Albi, Alves, Anderson, Andrews, Anthony-Twarog, Artymowicz, Bally, Baraffe, Barrado y Navascués, Barrado y Navascués, Bertout, Bouwman, Briceño, Briceño, Béjar, Calvet, Calvet, Calvet, Cardelli, Carpenter, Cieza, Cieza, Cieza, Clarke, Comerón, D'Alessio, D'Antona, Dahm, Dahm, Dahm, Dahm, Diolaiti, Dotter, Dullemond, Eisner, Eisner, Evans, Evans, Evans, Fazio, Fedele, Fedele, Finkbeiner, Flaherty, Furlan, Garcia Lopez, Gatti, Genzel, Gullbring, Gustafsson, Gutermuth, Gutermuth, Gâlfalk, Haisch, Hamann, Hartigan, Hartigan, Hartigan, Hartmann, Hartmann, Hartmann, Hartmann, Hartmann, Hartmann, Henning, Herbig, Herbig, Herczeg, Hernández, Hernández, Hernández, Hernández, Hillenbrand, Hillenbrand, Hillenbrand, Hirota, Huélamo, Isella, Kenyon, Kenyon, Kramer, Kraus, Kurucz, Kurucz, Kwan, Lada, Lada, Leinert, Lombardi, Luhman, Luhman, Luhman, M. Fang, Maddalena, Mamajek, Meeus, Megeath, Miesch, Mohanty, Monnier, Monnier, Muzerolle, Muzerolle, Muzerolle, Muzerolle, Muzerolle, Muzerolle, Najita, Natta, Natta, Osterloh, Quillen, R. van Boekel, Reipurth, Rice, Rieke, Román-Zúñiga, Rucinski, Sacco, Setiawan, Shu, Sicilia-Aguilar, Sicilia-Aguilar, Sicilia-Aguilar, Sicilia-Aguilar, Sicilia-Aguilar, Siess, Siess, Skrutskie, Spezzi, Strom, Strom, Th. Henning, Valdes, van der Plas, Vinkovic, Vinkovic, W. Wang, White, Wilson, Winston, Young   +152 more
core   +2 more sources

Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis [PDF]

, 2017
Circular RNAs (circRNAs) constitute a family of transcripts with unique structures and still largely unknown functions. Their biogenesis, which proceeds via a back-splicing reaction, is fairly well characterized, whereas their role in the modulation of ...
Andronache, Adrian, Bozzoni, Irene, Briganti, Francesca, DI TIMOTEO, Gaia, Fatica, Alessandro, Laneve, Pietro, Legnini, Ivano, Morlando, Mariangela, Rajewsky, Nikolaus, Rossi, Francesca, Santini, Tiziana, Sthandier, Olga Elena, Wade, Mark   +12 more
core   +3 more sources

Elevated TRIM25 Impairs Poly (ADP‐ribose) Metabolism via PARG Degradation and Mediates Compression‐Induced Intervertebral Disc Degeneration

Advanced Science, EarlyView.
TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng, Haiyang Gao, Wenbo Wu, Pengzhi Shi, Xianglong Chen, Zimu Yu, Wang Wu, Kangcheng Zhao, Cao Yang, Yukun Zhang   +9 more
wiley   +1 more source

m6A-Mediated IRS1 Regulates the Development of Oral Squamous Cell Carcinoma through p53/Line-1 Signaling

Frontiers in Bioscience-Landmark
Background: The importance of N6-methyladenosine (m6A) modification in tumorigenesis and progression have been highlighted. This study aimed to investigate the modification of insulin receptor substrate 1 (IRS1) by m6A and its role in oral squamous cell ...
Yanbo Xiao, Xuan Zhu, Qun Li, Zongkang Wang, Qiaojuan Zuo, Xun Liu, Jin Tan   +6 more
doaj   +1 more source

m6A RNA methylation regulators predict prognosis and indicate characteristics of tumour microenvironment infiltration in acute myeloid leukaemia

Epigenetics, 2023
Patients with acute myeloid leukaemia (AML) have poor prognoses and low overall survival (OS) rates owing to its heterogeneity and the complexity of its tumour microenvironment (TME).
Xinai Liao, Ling Chen, Jingru Liu, Haoran Hu, Diyu Hou, Ruolan You, Xiaoting Wang, Huifang Huang   +7 more
doaj   +1 more source