Results 111 to 120 of about 63,662 (384)

Crosstalk between m6A modification and alternative splicing during cancer progression

Clinical and Translational Medicine, 2023
Background N6‐methyladenosine (m6A), the most prevalent internal mRNA modification in eukaryotes, is added by m6A methyltransferases, removed by m6A demethylases and recognised by m6A‐binding proteins.
Zhi-man Zhu, Fu-chun Huo, Jian Zhang, Hong-Jian Shan, Dongsheng Pei   +4 more
semanticscholar   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Salsolinol as an RNA m6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

Neural Regeneration Research
Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, Sal) is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, an environmental toxin that causes Parkinson ...
Jianan Wang, Yuanyuan Ran, Zihan Li, Tianyuan Zhao, Fangfang Zhang, Juan Wang, Zongjian Liu, Xuechai Chen   +7 more
doaj   +1 more source

Current epigenetic aspects the clinical kidney researcher should embrace [PDF]

, 2017
Chronic kidney disease (CKD), affecting 10-12% of the world's adult population, is associated with a considerably elevated risk of serious comorbidities, in particular, premature vascular disease and death.
Ekström, Tomas J., Nordfors, Louise, Shiels, Paul G., Stenvinkel, Peter, Van Craenenbroeck, Amaryllis H., Witasp, Anna   +5 more
core   +1 more source

ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression

Experimental and Molecular Medicine, 2023
Improving health and delaying aging is the focus of medical research. Previous studies have shown that mesenchymal stem cell (MSC) senescence is closely related to organic aging and the development of aging-related diseases such as osteoarthritis (OA ...
Guiwen Ye, Jinteng Li, Wenhui Yu, Zhongyu Xie, Guan Zheng, Wenjie Liu, Shan Wang, Qian Cao, Jiajie Lin, Zepeng Su, Dateng Li, Yunshu Che, Shuai Fan, Peng Wang, Yanfeng Wu, Huiyong Shen   +15 more
semanticscholar   +1 more source

Positive Feedback Loop of Histone Lactylation‐Driven HNRNPC Promotes Autophagy to Confer Pancreatic Ductal Adenocarcinoma Gemcitabine Resistance

Advanced Science, EarlyView.
Histone 3 lysine18 lactylation (H3K18la) drives heterogeneous nuclear ribonucleoprotein C (HNRNPC) overexpression, activating autophagy to mediate gemcitabine resistance by stabilizing TNF receptor‐associated factor 6 (TRAF6) mRNA. Concurrently, HNRNPC stabilizes aldehyde dehydrogenase 1 family member A3 (ALDH1A3) mRNA, which enhances glycolysis and ...
Xi‐Tai Huang, Jiao Chen, En‐Liang Zhu, Ming‐Jian Ma, Yang‐Yin‐Hui Yu, Ying‐Qin Zhu, Jing‐Yuan Ye, Jin‐Zhao Xie, Zi‐Yi Zhao, Xiao‐Yu Yin   +9 more
wiley   +1 more source

Gene Expression Profile and Prognostic Value of m6A RNA Methylation Regulators in Hepatocellular Carcinoma

Journal of Hepatocellular Carcinoma, 2021
Xian Chang,1,* Yang-Fan Lv,2,* Jing He,3,* Ya Cao,2 Chang-Qing Li,1 Qiao-Nan Guo2 1Department of Orthopedics, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, People’s Republic of China; 2Department ...
Chang X, Lv YF, He J, Cao Y, Li CQ, Guo QN   +5 more
doaj  

Non-Gaussianity from Lifshitz Scalar

, 2010
A Lifshitz scalar with the dynamical critical exponent z = 3 obtains scale-invariant, super-horizon field fluctuations without the need of an inflationary era.
, B. Chen, C. Charmousis, C. Cheung, C. Cheung, C.T. Byrnes, C.T. Byrnes, D. Babich, D. Langlois, D. Langlois, D. Seery, D. Seery, D. Seery, D. Seery, E. Komatsu ., F. Arroja, G. Calcagni, H.R.S. Cogollo, J. Khoury, J.M. Maldacena, K. Izumi, Keisuke Izumi, L. Kofman, L. Senatore, M. Kawasaki, N. Arkani-Hamed, N. Bartolo, P. Creminelli, Q.-G. Huang, Q.-G. Huang, Q.-G. Huang, R. Holman, S. Mizuno, S. Mukohyama, S. Mukohyama, S. Mukohyama, S. Renaux-Petel, Shinji Mukohyama, T. Harada, T. Kobayashi, T. Suyama, Takeshi Kobayashi, X. Chen, X. Chen, X. Chen, X. Chen, X. Gao, X. Gao, X. Gao, X. Gao   +49 more
core   +1 more source

Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis [PDF]

, 2017
Circular RNAs (circRNAs) constitute a family of transcripts with unique structures and still largely unknown functions. Their biogenesis, which proceeds via a back-splicing reaction, is fairly well characterized, whereas their role in the modulation of ...
Andronache, Adrian, Bozzoni, Irene, Briganti, Francesca, DI TIMOTEO, Gaia, Fatica, Alessandro, Laneve, Pietro, Legnini, Ivano, Morlando, Mariangela, Rajewsky, Nikolaus, Rossi, Francesca, Santini, Tiziana, Sthandier, Olga Elena, Wade, Mark   +12 more
core   +2 more sources

The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases [PDF]

, 2021
Zuyao Chen, Xiaolin Zhong, Min Xia, Jing Zhong   +3 more
openalex   +1 more source