Results 231 to 240 of about 58,783 (322)

Mechanisms at the Intersection of lncRNA and m6A Biology. [PDF]

Noncoding RNA
Gonzalez SJ, Linares E, Swain AMP, Johnson AM.   +3 more
europepmc   +1 more source

The multifaceted roles of the ACSL family in cancer: Metabolic reprogramming, ferroptosis regulation and tumour immune microenvironment remodelling

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
The acyl‐CoA synthetase long‐chain (ACSL) family consists of five members, which exhibit a synergistic effect in promoting tumour lipid metabolism for energy supply. Specifically, ACSL3 and ACSL4 have antagonistic effects on the mechanisms related to ferroptosis in tumour cells.
Haocai Li, Weijian Wang, Juncheng Zhan, Yuxiang Xiao, Xiaoping Chen, Chen Su, Peng Zhu   +6 more
wiley   +1 more source

Mettl3-mediated m6A disruption of olfactory bulb glutamatergic metabolism homeostasis via the Wnt pathway in aging leads to olfactory dysfunction. [PDF]

Cell Mol Life Sci
Hu W, Wang XY, Zhan XJ, Pei P, Kong YR, Ji J, Liu J, Wang S, Tai J.   +8 more
europepmc   +1 more source

ALKBH5‐Driven m6A Demethylation Boosts Inflammation and Autophagy in LPS‐Stimulated Macrophages

Immunity, Inflammation and Disease, Volume 14, Issue 3, March 2026.
ABSTRACT Purpose Acute Respiratory Distress Syndrome (ARDS) remains a critical health threat with limited pharmacological treatments. This study investigates the role of the N6‐methyladenosine (m6A) demethylase AlkB homolog 5 (ALKBH5) in alveolar macrophages and its subsequent impact on inflammation and autophagy during ARDS pathogenesis.
Gui Wang, Ting Zhou, Shujun Zhou
wiley   +1 more source

Magnesium ions facilitate osteogenic differentiation and intervertebral fusion <i>via</i> m6A methylation of RhoA mRNA. [PDF]

J Orthop Translat
Xu H, Li L, Zhang F, Shao M, Li C, Xue Y, Li D, Lin Z, Gong Z, Wu J, Luo Z, Shi Z, Xia X, Wang H, Ma X, Jiang J, Gu X, Liu Y, Lu X, Lyu F.   +19 more
europepmc   +1 more source

RNA‐Based Therapies for Inherited Metabolic Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT Inherited metabolic disorders (IMDs) are a diverse and complex group of genetic conditions resulting from deficiencies in enzymes, transporters, or cofactors. These deficiencies lead to metabolic dysfunction and severe clinical consequences. Despite significant progress in understanding their molecular basis, treatment options remain limited ...
Reddy Sreekanth Vootukuri, Sonam Gurung, Roopkatha Ghosh, Philippa B. Mills, Julien Baruteau, Haiyan Zhou   +5 more
wiley   +1 more source

Integrated Analysis of CD1A Immune Infiltration and Competing Endogenous RNA Networks in COAD

International Journal of General Medicine
Houxi Xu,1,2,* Hongqun Zhang,1,3,* Songxian Sun,2,* Jingyuan Zhang,2 Jiege Huo,1,3 Chunxiang Zhou2 1Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing, University of Chinese Medicine, Nanjing, People’s ...
Xu H, Zhang H, Sun S, Zhang J, Huo J, Zhou C   +5 more
doaj  

Differences in the expression profiles of m6A-related genes and the prognostic role in immunotherapy for lung adenocarcinoma patients. [PDF]

Front Oncol
Zhang Z, Yang Y, Bai G, Xue C, Zhang X.
europepmc   +1 more source

HOXA5 Suppresses NEK7‐Mediated Alveolar Epithelial Pyroptosis in Acute Lung Injury by Transcriptionally Inhibiting KAT2A

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 3, March 2026.
ABSTRACT Alveolar epithelial cell pyroptosis exacerbates inflammation and tissue damage by releasing inflammatory mediators, thereby promoting the development of acute lung injury (ALI). However, the fundamental mechanism underlying alveolar epithelial cell pyroptosis in ALI has not yet been elucidated. Lipopolysaccharide (LPS) was used to simulate ALI
Lei Wang, Heng Fan, Qi Wang, Cheng‐Jie Jiang, Dan‐Hui Li, Ji‐Hui Ye   +5 more
wiley   +1 more source

The emerging role of m⁶A methylation in prostate-related diseases: mechanisms and clinical implications. [PDF]

Front Immunol
Xie Q, Zhao H, Yang X, Zhang H, Liu H, Pan J, Li Y, Fan D, Fan X.   +8 more
europepmc   +1 more source