Results 31 to 40 of about 58,783 (322)
Nature Communications, 2023 m6A modification has been reported to play roles in many developmental and pathological processes, but its role in AKI remains poorly understood.
Juntao Chen +10 more
semanticscholar +1 more source
Cyclin D1 integrates G9a-mediated histone methylation. [PDF]
, 2019 Lysine methylation of histones and non-histone substrates by the SET domain containing protein lysine methyltransferase (KMT) G9a/EHMT2 governs transcription contributing to apoptosis, aberrant cell growth, and pluripotency.
Casimiro, Mathew C. +13 more
core +2 more sources
The roles and mechanism of m6A RNA methylation regulators in cancer immunity.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023 N6-methyladenosine (m6A), the most common internal modification in RNA, can be regulated by three types of regulators, including methyltransferases (writers), demethylases (erasers), and m6A binding proteins (readers). Recently, immunotherapy represented
Lu Chen +11 more
semanticscholar +1 more source
Epigenetics, 2023 Cerebral ischaemiareperfusion injury is an important pathological process in nervous system diseases during which neurons undergo oxygenglucose deprivation and reoxygenation (OGD/R) injury. No study has used epitranscriptomics to explore the characteristics and mechanism of injury.
Chi Zhang +12 more
openaire +3 more sources
m6a RNA methylation: the implications for health and disease [PDF]
, 2014 The recent resurgence of interest in m6a has been spurred by some intriguing findings detailing the effects and dynamics of this epigenetic modification.
McGuinness, D., Mcguinness, D.H.
core +1 more source
Parkinson's Disease, 2013 Background. Parkinson’s disease (PD) is a neurodegenerative condition with complex subtleties, making it challenging for physicians to fully inform their patients.
Galit Kleiner-Fisman +2 more
doaj +1 more source
Signal Transduction and Targeted Therapy, 2021 N6-methyladenosine (m6A), and its reader protein YTHDF1, play a pivotal role in human tumorigenesis by affecting nearly every stage of RNA metabolism. Autophagy activation is one of the ways by which cancer cells survive hypoxia.
Qing Li +10 more
semanticscholar +1 more source
Nature Chemical Biology, 2020 The biological function and origin of m6A in DNA have been widely debated. A new study demonstrates that the majority of m6A in DNA originates from RNA catabolism via a nucleotide salvage pathway.
Spingardi, P, Kriaucionis, S
openaire +2 more sources
m6A RNA Methylation in Cardiovascular Diseases [PDF]
Molecular Therapy, 2020 Cardiovascular diseases (CVDs) remain the leading cause of death and disability worldwide, despite marked improvements in prevention, diagnosis, and early intervention. There is an urgent need to discover more effective therapeutic strategies, which would be facilitated by a more in-depth understanding of CVDs and their underlying molecular mechanisms.
Siyi, Wu +3 more
openaire +2 more sources
Improved $\alpha^4$ Term of the Electron Anomalous Magnetic Moment [PDF]
, 2005 We report a new value of electron $g-2$, or $a_e$, from 891 Feynman diagrams of order $\alpha^4$. The FORTRAN codes of 373 diagrams containing closed electron loops have been verified by at least two independent formulations.
A. Petermann +16 more
core +1 more source