Results 51 to 60 of about 58,783 (322)
m6A methyltransferase METTL3 promotes the progression of prostate cancer via m6A-modified LEF1.
European review for medical and pharmacological sciences, 2020 This study aims to uncover the regulatory effects of METTL3 on promoting the progression of prostate cancer (PCa) through N6-Methyladenosine (m6A) methylation on LEF1 mRNA.The relative levels of METTL3 and LEF1 in 48 paired PCa tissues and adjacent ones were determined by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR).
Ma, X.-X., Cao, Z.-G., Zhao, S.-L.
openaire +2 more sources
Crosstalk between RNA Metabolism and Cellular Stress Responses during Zika Virus Replication
Pathogens, 2020 Zika virus (ZIKV) is a mosquito-borne virus associated with neurological disorders such as Guillain-Barré syndrome and microcephaly. In humans, ZIKV is able to replicate in cell types from different tissues including placental cells, neurons, and ...
Aarón Oyarzún-Arrau +4 more
doaj +1 more source
Epigenetics, 2021 Accumulating evidence has demonstrated that N6-methyladenosine (m6A) plays important roles in various cancers, making it essential to profile m6A modifications at a transcriptome-wide scale in colorectal cancer (CRC).
Zhen Zhang +10 more
doaj +1 more source
Exploration of Medicine, 2023 m6A RNA methylation, a predominant type of RNA modification, is involved in regulating mRNA splicing, stability, and translation as well as the interaction between nucleoproteins and noncoding RNAs.
Hiromichi Sato +10 more
doaj +1 more source
m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer.
Cancer Cell, 2020 N6-Methyladenosine (m6A) RNA modification has emerged in recent years as a new layer of regulatory mechanism controlling gene expression in eukaryotes. As a reversible epigenetic modification found not only in messenger RNAs but also in non-coding RNAs ...
Huilin Huang, Hengyou Weng, Jianjun Chen
semanticscholar +1 more source
The how and why of lncRNA function: An innate immune perspective. [PDF]
, 2020 Next-generation sequencing has provided a more complete picture of the composition of the human transcriptome indicating that much of the "blueprint" is a vastness of poorly understood non-protein-coding transcripts.
Carpenter, Susan +2 more
core
Interactive influences of prior knowledge on episodic memory
iScienceSummary: Many species adapt to their environments by accruing relevant knowledge and expertise, which in turn shapes memory formation. Human experts remember items in their field better than novices, but different types of knowledge or exposure influence
Erik A. Wing +2 more
doaj +1 more source
Exploring the Epigenetic Regulatory Role of m6A-Associated SNPs in Type 2 Diabetes Pathogenesis
Pharmacogenomics and Personalized Medicine, 2021 Miao Chen,1,2 Weimin Lin,1 Jianru Yi,1,2 Zhihe Zhao1,2 1State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, People’s Republic of China; 2Department ...
Chen M, Lin W, Yi J, Zhao Z
doaj
Epigenetics, 2023 Doxorubicin (DOX) resistance in breast cancer (BC) poses a huge challenge for the therapeutic effect on BC. Lnc KCNQ1OT1 play crucial roles in chemotherapy resistance.
Zhiyang Zhou +4 more
doaj +1 more source
Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d [PDF]
, 2018 N6-methyladenosine (m6A) is the most abundant mRNA modification in eukaryotes, playing crucial roles in multiple biological processes. m6A is catalyzed by the activity of Mettl3, which depends on additional proteins whose precise functions remain poorly ...
Andrade-Navarro, Miguel A. +15 more
core +4 more sources