Results 81 to 90 of about 63,662 (384)
Advanced Materials Technologies, EarlyView.This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang +4 more
wiley +1 more source
Epigenetics, 2023 The most prominent RNA modification – N6-methyladenosine (m6A) – affects gene regulation and cancer progression. The extent and effect of m6A on long non-coding RNAs (lncRNAs) is, however, still not clear. The most established method for m6A detection is
Raulas Krusnauskas +4 more
doaj +1 more source
Towards the higher point holographic momentum space amplitudes [PDF]
, 2019 In this paper, we calculate higher point tree level vector amplitudes propagating in AdS$_4$. We use bulk perturbation theory to compute tree level Witten diagrams.
Albayrak, Soner, Kharel, Savan
core +4 more sources
m6A reader suppression bolsters HSC expansion [PDF]
Cell Research, 2018 Comment on Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion. [Cell Res. 2018]
Huang, Xinxin, Broxmeyer, Hal E.
openaire +2 more sources
Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS
Advanced Science, EarlyView.This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu +14 more
wiley +1 more source
Identifying cortical specific long noncoding RNAs modified by m6A RNA methylation in mouse brains
Epigenetics, 2021 Proper development of the mammalian cerebral cortex relies on precise gene expression regulation. Increasing evidence shows that cortical development is regulated by both mRNAs and long noncoding RNAs (lncRNAs), which also are modified by N6 ...
Yanzhen Nie +6 more
doaj +1 more source
Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation [PDF]
, 2017 Transcription and translation are two main pillars of gene expression. Due to the different timings, spots of action, and mechanisms of regulation, these processes are mainly regarded as distinct and generally uncoupled, despite serving a common purpose.
Agami, R. (Reuven) +6 more
core +4 more sources
Cell & BioscienceN6-methyladenosine (m6A) is dynamically regulated by methyltransferases (termed “writers”) and demethylases (referred to as “erasers”), facilitating a reversible modulation.
Zewei Gao +4 more
semanticscholar +1 more source
Advanced Science, EarlyView.METTL1 and its mediated m7G tRNA modification are significantly up‐regulated after partial hepatectomy (PHx). Overexpression of METTL1 improves the efficiency of liver regeneration after PHx, increases the proliferation of hepatocytes, and accelerates the recovery of liver function.
Manling Huang +18 more
wiley +1 more source
Cancellation of Infrared Divergence in Inclusive Production of Heavy Quarkonia
, 2016 A scheme is presented here to cancel out the topologically unfactorized infrared divergences in the inclusive production of heavy quarkonia, which affect the NRQCD factorization of these processes.
Zhou, Gao-Liang
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