Results 81 to 90 of about 58,783 (322)
Photon propagation in a cold axion condensate [PDF]
, 2013 We discuss some striking properties of photons propagating in a cold axion condensate oscillating coherently in time with a frequency $1/m_a$. Three effects are discussed in this contribution: (a) due to the time dependence of the background, photons ...
Espriu, Domenec, Renau, Albert
core +1 more source
Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders
Advanced Science, EarlyView.In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang +22 more
wiley +1 more source
Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism
Cell Research, 2018 N6-methyladenosine (m6A) is a chemical modification present in multiple RNA species, being most abundant in mRNAs. Studies on enzymes or factors that catalyze, recognize, and remove m6A have revealed its comprehensive roles in almost every aspect of mRNA
Ying Yang +3 more
semanticscholar +1 more source
Towards the higher point holographic momentum space amplitudes [PDF]
, 2019 In this paper, we calculate higher point tree level vector amplitudes propagating in AdS$_4$. We use bulk perturbation theory to compute tree level Witten diagrams.
Albayrak, Soner, Kharel, Savan
core +4 more sources
Advanced Science, EarlyView.This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang +11 more
wiley +1 more source
RNA m6A modification, signals for degradation or stabilisation?
Biochemical Society TransactionsThe RNA modification N6-methyladenosine (m6A) is conserved across eukaryotes, and profoundly influences RNA metabolism, including regulating RNA stability. METTL3 and METTL14, together with several accessory components, form a ‘writer’ complex catalysing
Guifeng Wei
semanticscholar +1 more source
$\kappa$-Deformations and Extended $\kappa$-Minkowski Spacetimes [PDF]
, 2014 We extend our previous study of Hopf-algebraic $\kappa$-deformations of all inhomogeneous orthogonal Lie algebras ${\rm iso}(g)$ as written in a tensorial and unified form.
Borowiec, Andrzej, Pachol, Anna
core +4 more sources
Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3
Advanced Science, EarlyView.In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang +16 more
wiley +1 more source
Cell & BioscienceN6-methyladenosine (m6A) is dynamically regulated by methyltransferases (termed “writers”) and demethylases (referred to as “erasers”), facilitating a reversible modulation.
Zewei Gao +4 more
semanticscholar +1 more source
The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation
Nucleic Acids Research, 2020 N 6-Methyladenosine (m6A) is the most abundant RNA modification in mammal mRNAs and increasing evidence suggests the key roles of m6A in human tumorigenesis.
Tao Liu +17 more
semanticscholar +1 more source