Results 291 to 300 of about 1,875,792 (320)

ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression.

Translational research : the journal of laboratory and clinical medicine, 2023
Aberrant N6-methyladenosine (m6A) modification of mRNAs contributes significantly to the epigenetic tumorigenesis, however, its precise role and the key targets in osteosarcoma (OS) are not defined.
Xueying An, Wenshu Wu, L. Yang, Jian Dong, B. Liu, Junxia Guo, Jianmei Chen, Baosheng Guo, W. Cao, Q. Jiang   +9 more
semanticscholar   +1 more source

m6A mRNA modification regulates mammalian spermatogenesis

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2019
Mammalian spermatogenesis is a highly specialized differentiation process involving precise regulatory mechanisms at the transcriptional, posttranscriptional, and translational levels. Emerging evidence has shown that N6-methyladenosine (m6A), an epitranscriptomic regulator of gene expression, can influence pre-mRNA splicing, mRNA export, turnover, and
Zhen, Lin, Ming-Han, Tong
openaire   +2 more sources

DDX21 mediates co-transcriptional RNA m6A modification to promote transcription termination and genome stability.

Molecules and Cells
N6-methyladenosine (m6A) is a crucial RNA modification that regulates diverse biological processes in human cells, but its co-transcriptional deposition and functions remain poorly understood.
Jin Hao, Qian Liu, Mengxia Liu, Xing Yang, Liu Wang, Si-Yi Su, Wen Xiao, Mengfan Zhang, Yi-Chang Zhang, Lan Zhang, Yu-Sheng Chen, Yun-Gui Yang, Jie Ren   +12 more
semanticscholar   +1 more source

Advances in the profiling of N6-methyladenosine (m6A) modifications

Biotechnology Advances, 2020
Over 160 RNA modifications have been identified, including N7-methylguanine (m7G), N6-methyladenosine (m6A), and 5-methylcytosine (m5C). These modifications play key roles in regulating the fate of RNA. In eukaryotes, m6A is the most abundant mRNA modification, accounting for over 80% of all RNA methylation modifications.
Hong-Xiang, Zheng, Xian-Sheng, Zhang, Na, Sui   +2 more
openaire   +2 more sources

m6A epitranscriptomic modification in diabetic microvascular complications

Trends in Pharmacological Sciences, 2023
N6-methyladenosine (m6A) modifications are modulated by m6A methyltransferases, m6A demethylases, and m6A-binding proteins. The dynamic and reversible patterns of m6A modification control cell fate programming by regulating RNA splicing, translation, and decay.
Li-Chan Lin, Zhi-Yan Liu, Jing-Jing Yang, Jian-Yuan Zhao, Hui Tao   +4 more
openaire   +2 more sources

METTL3-mediated m6A modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression

Annals of the Rheumatic Diseases, 2021
Objective The aim of the study was to investigate the role and regulatory mechanisms of fibroblast-like synoviocytes (FLSs) and their senescence in the progression of osteoarthritis (OA). Methods Synovial tissues from normal patients and patients with OA
Xiang Chen, W. Gong, Xiaoyan Shao, T. Shi, Lei Zhang, Jian Dong, Yong-zhao Shi, Siyu Shen, Jianghui Qin, Q. Jiang, Baosheng Guo   +10 more
semanticscholar   +1 more source

The Role of RNA m6A Modification in Cancer Glycolytic Reprogramming

Current Gene Therapy, 2023
Abstract: As one of the main characteristics of neoplasia, metabolic reprogramming provides nutrition and energy to enhance cell proliferation and maintain environment homeostasis. Glycolysis is one of the most important components of cancer metabolism and the Warburg effect contributes to the competitive advantages of cancer cells in the threatened ...
Yuanqi, Li, Hao, Huang, Shaoxian, Wu, You, Zhou, Tao, Huang, Jingting, Jiang   +5 more
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PM2.5 induces pulmonary microvascular injury in COPD via METTL16-mediated m6A modification.

Environmental Pollution, 2022
Fine particulate matter (PM2.5) exposure is a significant cause of chronic obstructive pulmonary disease (COPD), but the detailed mechanisms involved in COPD remain unclear.
Xiaolan Guo, Yuyin Lin, Ying-Zhi Lin, Yue Zhong, Hongjiao Yu, Yibin Huang, Jingwen Yang, Ying Cai, Fengdong Liu, Yuanyuan Li, Qian Zhang, Jianwei Dai   +11 more
semanticscholar   +1 more source

m6A and beyond: RNA modifications shaping angiogenesis

Trends in Molecular Medicine
RNA modifications are crucial post-transcriptional processes that significantly influence gene expression, RNA stability, nuclear transport, and translational capacity. Angiogenesis, the formation of new blood vessels, is a physiological process that is dysregulated in many pathological conditions, including ocular diseases, immune disorders, and ...
Yu, Luan, Renbing, Jia, Peiwei, Chai, Xianqun, Fan   +3 more
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m6A epitranscriptomic modification of inflammation in cardiovascular disease

International Immunopharmacology
Cardiovascular disease is currently the number one cause of death endangering human health. There is currently a large body of research showing that the development of cardiovascular disease and its complications is often accompanied by inflammatory processes.
Yun-Sen Zhang, Zhi-Yan Liu, Zhen-Yu Liu, Li-Chan Lin, Qi Chen, Jian-Yuan Zhao, Hui Tao   +6 more
openaire   +2 more sources