Results 281 to 290 of about 1,875,792 (320)

N6‐methyladenosine (m6A) modification in gynecological malignancies

Journal of Cellular Physiology, 2022
AbstractN6‐methyladenosine (m6A) modification is one of the most abundant modifications in eukaryotic mRNA, regulated by m6A methyltransferase and demethylase. m6A modified RNA is specifically recognized and bound by m6A recognition proteins, which mediate splicing, maturation, exonucleation, degradation, and translation.
Chunmei Zhang, Ning Liu
openaire   +2 more sources

RNA m6A modification and its function in diseases [PDF]

Frontiers of Medicine, 2018
N6-methyladenosine (m6A) is the most common post-transcriptional RNA modification throughout the transcriptome, affecting fundamental aspects of RNA metabolism. m6A modification could be installed by m6A "writers" composed of core catalytic components (METTL3/METTL14/WTAP) and newly defined regulators and removed by m6A "erasers" (FTO and ALKBH5).
Richard A Flavell, Hua-Bing Li
exaly   +3 more sources

m6A Modification and Implications for microRNAs

MicroRNA, 2017
RNA is chemically modified with over 100 distinct reactions. Among these reactions, methylation is probably the most extensively studied modification on the RNA molecule. Studies suggest methylation of Adenine residues (m6A) to be widespread in the transcriptome with potentially important roles in biological processes.Here, we review recent literature ...
Ayse Elif, Erson-Bensan, Oguzhan, Begik
openaire   +2 more sources

RNA m6A modifications in mammalian gametogenesis and pregnancy

Reproduction, 2022
  In brief RNA modifications play key roles in regulating various biological processes. This article discusses and summarizes the recent advances of RNA m6A modifications related to mammalian gametogenesis, early embryonic development, and miscarriage.
Xuesong Sui, Arne Klungland, Lu Gao
openaire   +2 more sources

METTL5-mediated 18S rRNA m6A modification promotes oncogenic mRNA translation and intrahepatic cholangiocarcinoma progression.

Molecular Therapy, 2023
Intrahepatic cholangiocarcinoma (ICC) is a deadly cancer with rapid tumor progression. While hyperactive mRNA translation caused by mis-regulated mRNA or tRNA modifications promotes ICC development, the role of rRNA modifications remains elusive.
Z. Dai, Wanjie Zhu, Yingdong Hou, Xinyue Zhang, Xuxin Ren, K. Lei, Junbin Liao, Haining Liu, Zhi-hang Chen, Sui Peng, Shaoqiang Li, Shuibin Lin, Ming Kuang   +12 more
semanticscholar   +1 more source

Regulation and functions of non-m6A mRNA modifications

Nature Reviews Molecular Cell Biology, 2023
Nucleobase modifications are prevalent in eukaryotic mRNA and their discovery has resulted in the emergence of epitranscriptomics as a research field. The most abundant internal (non-cap) mRNA modification is N6-methyladenosine (m6A), the study of which has revolutionized our understanding of post-transcriptional gene regulation.
Hanxiao Sun, Kai Li, Cong Liu, Chengqi Yi   +3 more
openaire   +2 more sources

METTL14 is decreased and regulates m6A modification of α‐synuclein in Parkinson's disease

Journal of Neurochemistry, 2023
N6‐methyladenosine (m6A), an emerging modification of messenger RNA, has been implicated in many biological processes. However, its role in Parkinson's disease (PD) remains largely unknown.
Honghu He, Qinxin Zhang, Jiajia Liao, J. Lei, Man Luo, Jianyi Huang, Meiling Chen, Yuefei Shen, Jin Wang, P. Xu, Yousheng Xiao   +10 more
semanticscholar   +1 more source

Molecular Mechanisms Driving mRNA Degradation by m6A Modification [PDF]

Trends in Genetics, 2020
N6-Methyladenosine (m6A), the most prevalent internal modification associated with eukaryotic mRNAs, influences many steps of mRNA metabolism, including splicing, export, and translation, as well as stability. Recent studies have revealed that m6A-containing mRNAs undergo one of two distinct pathways of rapid degradation: deadenylation via the YT521-B ...
Junho Choe, Yoon Ki Kim
exaly   +3 more sources

The functional roles of m6A modification in prostate cancer

PROTEOMICS – Clinical Applications, 2023
AbstractProstate cancer (PCa) is the most prevalent malignancy of the male genitourinary system, and its etiology suggests that genetics is an essential risk factor for its development and progression, while exogenous factors may have an significant impact on this risk.
Fa Zhang, Feng Chen, Chao Wang, Feng‐Hai Zhou   +3 more
openaire   +2 more sources

METTL3-mediated m6A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance

Gut, 2019
Objective N6-methyladenosine (m6A) RNA methylation and its associated methyltransferase METTL3 are involved in tumour initiation and progression via the regulation of RNA function.
Qiang Wang, Chen Chen, Q. Ding, Yan Zhao, Zhangding Wang, Junjie Chen, Zerun Jiang, Yan Zhang, Guifang Xu, Jing-Jing Zhang, Jianwei Zhou, Beicheng Sun, X. Zou, Shouyu Wang   +13 more
semanticscholar   +1 more source