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m6A epitranscriptomic modification of inflammation in cardiovascular disease
International ImmunopharmacologyCardiovascular disease is currently the number one cause of death endangering human health. There is currently a large body of research showing that the development of cardiovascular disease and its complications is often accompanied by inflammatory processes.
Yun-Sen Zhang +6 more
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m6A modification of mRNA in skin diseases.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2022N6-methyladenosine (m6A) is the predominant post-transcriptional modification for eukaryotic mRNA. It's regulated by methyltransferases, demethylases, and m6A binding proteins, and plays an important role in regulating splicing, translation, and degradation of mRNA.
Zhuoxian, Yan, Pengfei, Liang
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Regulation and application of m6A modification in tumor immunity
Science China Life SciencesThe m6A modification is an RNA modification that impacts various processes of RNA molecules, including transcription, splicing, stability, and translation. Recently, researchers have discovered that the presence of m6A modification can influence the interaction between tumor cells and immune cells and also play a role in regulating the expression of ...
Qunli, Xiong +3 more
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Roles of m6A modification in neurological diseases.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2022N6-methyladenosine (m6A) methylation modification is one of the most common epigenetic modifications for eukaryotic mRNA. Under the catalytic regulation of relevant enzymes, m6A participates in the body's pathophysiological processes via mediating RNA transcription, splicing, translation, and decay.
Yuan, Zhang +5 more
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Role of m6A modifications in immune evasion and immunotherapy
Medical OncologyRNA modification has garnered increasing attention in recent years due to its pivotal role in tumorigenesis and immune surveillance. N6-methyladenosine (m6A) modification is the most prevalent RNA modification, which can affect the expression of RNA by methylating adenylate at the sixth N position to regulate the occurrence and development of tumors ...
Chunyu Wu +7 more
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The role of N6-methyladenosine (m6A) modification in plants
Theoretical and Applied GeneticsN6-methyladenosine (m6A) modification is the most prevalent chemical modification identified in eukaryotic mRNA molecules, playing a pivotal role in plant growth, development, and responses to both biotic and abiotic stresses. m6A modification is co-regulated by methyltransferases and demethylases, with recognition proteins specifically binding to m6A ...
Cui-Xian Qin +9 more
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[Progress in epigenetic modification of mRNA and the function of m6A modification].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2019Messenger RNA (mRNA) can be modified by more than 100 chemical modifications. Among these modifications, N6-methyladenosine (m⁶A) is one of the most prevalent modifications. During the processes of cells differentiation, embryo development or stress, m⁶A can be modified on key mRNAs and regulate the progress of cells through modulating mRNA metabolism ...
Haili, Gan +5 more
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m6A modification and its clinical applications in gynaecological cancer
ApoptosisN6-methyladenosine (m6A) RNA modification plays a pivotal role in gynaecological cancers by regulating tumor initiation, progression, and therapeutic resistance. m6A RNA modification include writers (METTL3/14, RBM15, ZC3H13, WTAP), which catalyze methylation; erasers (ALKBH5, FTO), which remove methyl groups; and readers (YTHDC1, YTHDF1/2/3, IGF2BP1/2/
Chavi Ahlawat +5 more
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mRNA modifications in cardiovascular biology and disease: with a focus on m6A modification
Cardiovascular Research, 2022Suresh Kumar Verma +2 more
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