Results 261 to 270 of about 836,621 (308)

The regulatory role of circGDI2 in hepatocellular carcinoma proliferation and glycolysis with the involvement of m6A modification. [PDF]

Noncoding RNA Res
Chen S, Xia H, Chen S.
europepmc   +1 more source

RBM15B-mediated m6A modification of FOXM1 activates the AURKA/TPX2 axis to promote epithelial-mesenchymal transition-driven endometrial cancer progression. [PDF]

Cell Adh Migr
Zhang L, Wu P.
europepmc   +1 more source

Decoding osteosarcoma pathogenesis: the pivotal influence of m⁶A modification. [PDF]

Epigenetics
Huang C, Han Z, Su J, Zhang M, Lin Y, He H, Tang Y, Guo P, Wang Y, Chen H.   +9 more
europepmc   +1 more source

M6A demethylase ALKBH5 mediated Igfbp4 mRNA m6A modification drives fibroblast activation and pathological upper airway fibrosis. [PDF]

Clin Transl Med
Wang J, Liao Z, Xu M, Zheng Y, Hu B, Xia Q, Xu H.   +6 more
europepmc   +1 more source

Modulation of circRNA Metabolism by m6A Modification [PDF]

Cell Reports, 2020
N6-methyladenosine (m6A) is an RNA modification well-known for its contribution to different processes controlling RNA metabolism, including splicing, stability, and translation of mRNA. Conversely, the role of m6A on the biogenesis and function of circular RNAs (circRNAs) has yet to be addressed.
Francesca Rossi, Alessio Colantoni, Alessandro Fatica   +2 more
exaly   +4 more sources

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Regulation and functions of non-m6A mRNA modifications

Nature Reviews Molecular Cell Biology, 2023
Nucleobase modifications are prevalent in eukaryotic mRNA and their discovery has resulted in the emergence of epitranscriptomics as a research field. The most abundant internal (non-cap) mRNA modification is N6-methyladenosine (m6A), the study of which has revolutionized our understanding of post-transcriptional gene regulation.
Chengqi Yi
exaly   +3 more sources

Exploring the role of m6A modification in cancer

PROTEOMICS, 2022
Abstract m6A is one of the most common, abundant, and conserved post‐transcriptional modifications that regulate broad biological processes in the human body through m6A regulators. m6A regulators are figuratively classified according to their functions: writers, erasers, and readers, which can methylate RNAs, demethylate RNAs, and ...
Yongqi Wei, Yin Li, Chunlai Lu
openaire   +2 more sources

The role of m6A modification in pediatric cancer

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2022
With the development of RNA modification research, the importance of N6-methyladenosine (m6A) in tumors cannot be ignored. m6A promotes the self-renewal of tumor stem cells and the proliferation of tumor cells. It affects post-transcriptional gene expression through epigenetic mechanisms, combining various factors to determine proteins' fate and ...
Yongping, Chen, Lei, Miao, Huiran, Lin, Zhenjian, Zhuo, Jing, He   +4 more
openaire   +2 more sources

N6‐methyladenosine (m6A) Modification in Preeclampsia

Reproductive Sciences, 2023
Recently, epitranscriptional modification of N6-methyladenosine (m6A) has received growing attention in the research on the pathogenesis of preeclampsia. Advances in m6A sequencing have revealed the molecular mechanism and importance of m6A modification.
Tingting Zhang, Ziyan Jiang, Nana Yang, Zhiping Ge, Qing Zuo, Shiyun Huang, Lizhou Sun   +6 more
openaire   +2 more sources

N6‐methyladenosine (m6A) modification in gynecological malignancies

Journal of Cellular Physiology, 2022
AbstractN6‐methyladenosine (m6A) modification is one of the most abundant modifications in eukaryotic mRNA, regulated by m6A methyltransferase and demethylase. m6A modified RNA is specifically recognized and bound by m6A recognition proteins, which mediate splicing, maturation, exonucleation, degradation, and translation.
Chunmei Zhang, Ning Liu
openaire   +2 more sources