Results 271 to 280 of about 836,621 (308)

The functional roles of m6A modification in prostate cancer

PROTEOMICS – Clinical Applications, 2023
AbstractProstate cancer (PCa) is the most prevalent malignancy of the male genitourinary system, and its etiology suggests that genetics is an essential risk factor for its development and progression, while exogenous factors may have an significant impact on this risk.
Fa Zhang, Feng Chen, Chao Wang, Feng‐Hai Zhou   +3 more
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RNA m6A modification and its function in diseases [PDF]

Frontiers of Medicine, 2018
N6-methyladenosine (m6A) is the most common post-transcriptional RNA modification throughout the transcriptome, affecting fundamental aspects of RNA metabolism. m6A modification could be installed by m6A "writers" composed of core catalytic components (METTL3/METTL14/WTAP) and newly defined regulators and removed by m6A "erasers" (FTO and ALKBH5).
Hua-Bing Li, Richard Flavell
exaly   +3 more sources

m6A Modification and Implications for microRNAs

MicroRNA, 2017
RNA is chemically modified with over 100 distinct reactions. Among these reactions, methylation is probably the most extensively studied modification on the RNA molecule. Studies suggest methylation of Adenine residues (m6A) to be widespread in the transcriptome with potentially important roles in biological processes.Here, we review recent literature ...
Ayse Elif, Erson-Bensan, Oguzhan, Begik
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RNA m6A modifications in mammalian gametogenesis and pregnancy

Reproduction, 2022
  In brief RNA modifications play key roles in regulating various biological processes. This article discusses and summarizes the recent advances of RNA m6A modifications related to mammalian gametogenesis, early embryonic development, and miscarriage.
Xuesong Sui, Arne Klungland, Lu Gao
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m6A epitranscriptomic modification in diabetic microvascular complications

Trends in Pharmacological Sciences, 2023
N6-methyladenosine (m6A) modifications are modulated by m6A methyltransferases, m6A demethylases, and m6A-binding proteins. The dynamic and reversible patterns of m6A modification control cell fate programming by regulating RNA splicing, translation, and decay.
Li-Chan Lin, Zhi-Yan Liu, Jing-Jing Yang, Jian-Yuan Zhao, Hui Tao   +4 more
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Advances in the profiling of N6-methyladenosine (m6A) modifications

Biotechnology Advances, 2020
Over 160 RNA modifications have been identified, including N7-methylguanine (m7G), N6-methyladenosine (m6A), and 5-methylcytosine (m5C). These modifications play key roles in regulating the fate of RNA. In eukaryotes, m6A is the most abundant mRNA modification, accounting for over 80% of all RNA methylation modifications.
Hong-Xiang, Zheng, Xian-Sheng, Zhang, Na, Sui   +2 more
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m6A mRNA modification regulates mammalian spermatogenesis

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2019
Mammalian spermatogenesis is a highly specialized differentiation process involving precise regulatory mechanisms at the transcriptional, posttranscriptional, and translational levels. Emerging evidence has shown that N6-methyladenosine (m6A), an epitranscriptomic regulator of gene expression, can influence pre-mRNA splicing, mRNA export, turnover, and
Zhen, Lin, Ming-Han, Tong
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The Role of RNA m6A Modification in Cancer Glycolytic Reprogramming

Current Gene Therapy, 2023
Abstract: As one of the main characteristics of neoplasia, metabolic reprogramming provides nutrition and energy to enhance cell proliferation and maintain environment homeostasis. Glycolysis is one of the most important components of cancer metabolism and the Warburg effect contributes to the competitive advantages of cancer cells in the threatened ...
Yuanqi, Li, Hao, Huang, Shaoxian, Wu, You, Zhou, Tao, Huang, Jingting, Jiang   +5 more
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RNA m6A modification meets plant hormones

Nature Plants
Plant hormones are essential signalling molecules that control and coordinate diverse physiological processes in plant development and adaptation to ever-fluctuating environments. This hormonal regulation of plant development and environmental responses has recently been shown to extensively involve the most widespread RNA modification, N6 ...
Lisha Shen, Hao Yu
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m6A and beyond: RNA modifications shaping angiogenesis

Trends in Molecular Medicine
RNA modifications are crucial post-transcriptional processes that significantly influence gene expression, RNA stability, nuclear transport, and translational capacity. Angiogenesis, the formation of new blood vessels, is a physiological process that is dysregulated in many pathological conditions, including ocular diseases, immune disorders, and ...
Yu, Luan, Renbing, Jia, Peiwei, Chai, Xianqun, Fan   +3 more
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