Results 271 to 280 of about 1,875,792 (320)

m6A modification negatively regulates translation by switching mRNA from polysome to P-body via IGF2BP3

Molecular Cell, 2023
In the cytoplasm, mRNAs are dynamically partitioned into translating and non-translating pools, but the mechanism for this regulation has largely remained elusive.
Yafen, Yu Zhou
exaly   +2 more sources

Current Insights into Obesity and m6A Modification

open access: yesBiomedicines
Obesity has emerged as a global health challenge, closely associated with multiple metabolic diseases, such as cardiovascular diseases, type 2 diabetes, and non-alcoholic fatty liver disease.
Chen Meng, Di Yang
semanticscholar   +3 more sources

The roles and implications of RNA m6A modification in cancer

Nature Reviews Clinical Oncology, 2023
Xiaolan Deng, Ying Qing, Huilin Huang
exaly   +2 more sources

Modulation of circRNA Metabolism by m6A Modification [PDF]

open access: yesCell Reports, 2020
N6-methyladenosine (m6A) is an RNA modification well-known for its contribution to different processes controlling RNA metabolism, including splicing, stability, and translation of mRNA. Conversely, the role of m6A on the biogenesis and function of circular RNAs (circRNAs) has yet to be addressed.
Gaia Di TIMOTEO   +2 more
exaly   +4 more sources

N6‐methyladenosine (m6A) Modification in Preeclampsia

Reproductive Sciences, 2023
Recently, epitranscriptional modification of N6-methyladenosine (m6A) has received growing attention in the research on the pathogenesis of preeclampsia. Advances in m6A sequencing have revealed the molecular mechanism and importance of m6A modification.
Tingting Zhang   +6 more
openaire   +2 more sources

RNA m6A modification meets plant hormones

Nature Plants
Plant hormones are essential signalling molecules that control and coordinate diverse physiological processes in plant development and adaptation to ever-fluctuating environments. This hormonal regulation of plant development and environmental responses has recently been shown to extensively involve the most widespread RNA modification, N6 ...
Lisha Shen, Hao Yu
semanticscholar   +3 more sources

The role of m6A modification in pediatric cancer

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2022
With the development of RNA modification research, the importance of N6-methyladenosine (m6A) in tumors cannot be ignored. m6A promotes the self-renewal of tumor stem cells and the proliferation of tumor cells. It affects post-transcriptional gene expression through epigenetic mechanisms, combining various factors to determine proteins' fate and ...
Yongping, Chen   +4 more
openaire   +2 more sources

Exploring the role of m6A modification in cancer

PROTEOMICS, 2022
Abstract m6A is one of the most common, abundant, and conserved post‐transcriptional modifications that regulate broad biological processes in the human body through m6A regulators. m6A regulators are figuratively classified according to their functions: writers, erasers, and readers, which can methylate RNAs, demethylate RNAs, and ...
Yongqi Wei, Yin Li, Chunlai Lu
openaire   +2 more sources

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