Results 1 to 10 of about 24,574 (283)

The functions and prognostic values of m6A RNA methylation regulators in thyroid carcinoma [PDF]

Cancer Cell International, 2021
Background N6-Methyladenosine (m6A) is the most common RNA modification and regulates RNA splicing, translation, translocation, and stability. Aberrant expression of m6A has been reported in various types of human cancers.
Zhi-Hao Yu, Shao-Ting Feng, Di Zhang, Xu-Chen Cao, Yue Yu, Xin Wang   +5 more
doaj   +2 more sources

The role of RNA m6A methylation in lipid metabolism

Frontiers in Endocrinology, 2022
The m6A methylation is the most numerous modification of mRNA in mammals, coordinated by RNA m6A methyltransferases, RNA m6A demethylases, and RNA m6A binding proteins. They change the RNA m6A methylation level in their specific manner.
Yuting Wang, Yujie Wang, Jiarui Gu, Tianhong Su, Xiaosong Gu, Yu Feng   +5 more
doaj   +3 more sources

m6A RNA methylation promotes XIST-mediated transcriptional repression [PDF]

, 2016
The long non-coding RNA X-inactive specific transcript (XIST) mediates the transcriptional silencing of genes on the X chromosome. Here we show that, in human cells, XIST is highly methylated with at least 78 N^6-methyladenosine (m^6A) residues—a ...
Deepak P. Patil, Chun‐Kan Chen, Brian F. Pickering, Amy Chow, Constanza Jackson, Mitchell Guttman, Samie R. Jaffrey   +6 more
openalex   +4 more sources

m6Acomet: large-scale functional prediction of individual m6A RNA methylation sites from an RNA co-methylation network [PDF]

BMC Bioinformatics, 2019
Background Over one hundred different types of post-transcriptional RNA modifications have been identified in human. Researchers discovered that RNA modifications can regulate various biological processes, and RNA methylation, especially N6 ...
Xiangyu Wu, Zhen Wei, Kunqi Chen, Qing Zhang, Jionglong Su, Hui Liu, Lin Zhang, Jia Meng   +7 more
doaj   +2 more sources

SSB cooperates with METTL16-mediated m6A RNA methylation to promote chemoresistance in colorectal cancer cells [PDF]

Cell Reports
Summary: m6A RNA methylation is the most prevalent internal modification in mammalian mRNAs and is involved in many biological processes. METTL16 is a recently identified RNA m6A methyltransferase.
Haixia Li, Emma Wilkinson, Yan-Hong Cui, Ming Sun, Kenneth Lu, Seungwon Yang, Marc Bissonnette, Yu-Ying He   +7 more
doaj   +2 more sources

Role of m6A RNA methylation regulators in pancreatic cancer: interactions and potential implications. [PDF]

Cancer Cell Int
Liao L, Xu X, Cao Y, Tang K, Xu Q.
europepmc   +3 more sources

Dynamic alterations in m⁶A RNA methylation profiles during involution of infantile hemangiomas. [PDF]

Front Oncol
Wu P, Cen Q, Shang Y, Liang J, Ma G.
europepmc   +3 more sources

Nurturing gut health: role of m6A RNA methylation in upholding the intestinal barrier. [PDF]

Cell Death Discov
Wang S, Yang Y, Jiang X, Zheng X, Wei Q, Dai W, Zhang X.   +6 more
europepmc   +3 more sources

Deregulation of m6A-RNA methylation impairs adaptive hypertrophic response and drives maladaptation via mTORC1-S6K1-hyperactivation and autophagy impairment. [PDF]

Cell Commun Signal
Annamalai K, Dilliker S, Buchholz E, Castro-Hernández R, Panyam N, Pommeranz A, Wiederhake P, Wery von Limont N, Hempel N, Ebner V, Swarnkar S, Mohamed BA, Streckfuss-Bömeke K, Steffens S, Herzig S, Ebert A, Fischer A, Toischer K.   +17 more
europepmc   +2 more sources

Ginsenoside Rh2 reduces m6A RNA methylation in cancer via the KIF26B-SRF positive feedback loop

Journal of Ginseng Research, 2021
Background: The underlying mechanisms of the potential tumor-suppressive effects of ginsenoside Rh2 are complex. N6-methyladenosine (m6A) RNA methylation is usually dysregulated in cancer.
Chunmei Hu, Linhan Yang, Yi Wang, Shijie Zhou, Jing Luo, Yi Gu   +5 more
doaj   +1 more source