Results 21 to 30 of about 937,277 (225)
m6A RNA methylation regulates the fate of endogenous retroviruses
Nature, 2021 Endogenous retroviruses (ERVs) are abundant and heterogenous groups of integrated retroviral sequences that affect genome regulation and cell physiology throughout their RNA-centred life cycle1. Failure to repress ERVs is associated with cancer, infertility, senescence and neurodegenerative diseases2,3.
Tomasz Chelmicki +9 more
semanticscholar +3 more sources
Altered m6A RNA methylation contributes to hippocampal memory deficits in Huntington’s disease mice [PDF]
Cellular and Molecular Life Sciences, 2022 N6-methyladenosine (m6A) regulates many aspects of RNA metabolism and is involved in learning and memory processes. Yet, the impact of a dysregulation of post-transcriptional m6A editing on synaptic impairments in neurodegenerative disorders remains ...
A. Pupak +9 more
semanticscholar +2 more sources
RNA m6A methylation regulators in ovarian cancer [PDF]
Cancer Cell International, 2021 AbstractN6-methyladenosine (m6A) is the most abundant RNA modification of mammalian mRNAs and plays a vital role in many diseases, especially tumours. In recent years, m6A has become the topic of intense discussion in epigenetics. M6A modification is dynamically regulated by methyltransferases, demethylases and RNA-binding proteins. Ovarian cancer (OC)
Jialu Guo +3 more
openaire +3 more sources
Frontiers in Pharmacology, 2022 N6-methyladenosine (m6A) RNA methylation has been considered the most prevalent, abundant, and conserved internal transcriptional modification throughout the eukaryotic mRNAs.
Zhaolin Chen +7 more
doaj +1 more source
N6-Methyladenosine Regulators Promote Malignant Progression of Gastric Adenocarcinoma
Frontiers in Oncology, 2022 N6-methyladenosine (m6A) RNA methylation is dynamically and reversibly regulated by methyltransferases, binding proteins, and demethylases. The restoration of m6A to adenosine could result in demethylation modifications.
Yibin Zhao +4 more
doaj +1 more source
The role of m6A RNA methylation regulator in meningioma
Aging, 2023 Meningiomas are common intracranial tumors, and the effect of surgical resection is often unsatisfactory. N6-Methyladenosine (m6A)-related regulator expression levels are related to cancer occurrence and development. This study aimed to investigate the roles of m6A RNA methylation regulators in meningiomas, as these are currently unclear.
Yang, Yu, Luo, Liqin, Zhou, Zhiwu
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Frontiers in Cell and Developmental Biology, 2023 Background:Helicobacter pylori (H.pylori) infection is an important factor in the occurrence of human gastric diseases, but its pathogenic mechanism is not clear.
Huan Li +11 more
doaj +1 more source
The Biogenesis and Precise Control of RNA m6A Methylation [PDF]
Trends in Genetics, 2020 N6-Methyladenosine (m6A) is the most prevalent internal RNA modification in mRNA, and has been found to be highly conserved and hard-coded in mammals and other eukaryotic species. The importance of m6A for gene expression regulation and cell fate decisions has been well acknowledged in the past few years.
Huilin, Huang +2 more
openaire +2 more sources
m6a RNA Methylation: The Implications for Health and Disease [PDF]
Journal of Cancer Science and Clinical Oncology, 2014 The recent resurgence of interest in m6a has been spurred by some intriguing findings detailing the effects and dynamics of this epigenetic modification. The m6a modification is a highly reactive and fluid modification which can respond rapidly to a broad variety of stimuli, and translate these signals into cellular activity.
Mcguinness, D.H., McGuinness, D.
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Effects of m6A RNA methylation regulators on endometrial cancer [PDF]
Journal of Clinical Laboratory Analysis, 2021 AbstractBackgroundThe modification 6‐methyladenine (m6A) is the most common type in RNA methylation. Our study aims to explore the bioinformatic analysis of m6A in endometrial cancer.MethodsThe expression of 23 m6A RNA methylation regulators was compared through The Cancer Genome Atlas (TCGA) database among 406 endometrial tissue and 19 normal tissue ...
Yanli Zhang, Yingjie Yang
openaire +2 more sources