Results 1 to 10 of about 62,835 (157)
m6A RNA methylation regulates mitochondrial function. [PDF]
Human Molecular GeneticsXiaoxi Zhuang, Allen C Zhu, Yongchao C
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m6A RNA methylation: from mechanisms to therapeutic potential
EMBO Journal, 2021 RNA carries a diverse array of chemical modifications that play important roles in the regulation of gene expression. N6‐methyladenosine (m6A), installed onto mRNA by the METTL3/METTL14 methyltransferase complex, is the most prevalent mRNA modification ...
Philip Cody He, Chuan He
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IET Systems Biology, 2022 N6‐methyladenosine (m6A) RNA methylation is correlated with carcinogenesis and dynamically possessed through the m6A RNA methylation regulators. This paper aimed to explore 13 m6A RNA methylation regulators' role in gastrointestinal cancer (GIC) and ...
Jiangtao Wang, Yandong Miao, Denghai Mi
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m6A RNA methylation modulates IFN-γ-stimulated intestinal epithelial cell-intrinsic antiparasitic defense. [PDF]
PLoS PathogensN6-methyladenosine (m6A) RNA methylation is one of the most prevalent reversible post-transcriptional RNA modifications and has been recognized as a crucial regulator of host immune responses.
Chansorena Pok +9 more
doaj +2 more sources
Ginsenoside Rh2 reduces m6A RNA methylation in cancer via the KIF26B-SRF positive feedback loop
Journal of Ginseng Research, 2021 Background: The underlying mechanisms of the potential tumor-suppressive effects of ginsenoside Rh2 are complex. N6-methyladenosine (m6A) RNA methylation is usually dysregulated in cancer.
Shijie Zhou, Yi Gu
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Multiple functions of m6A RNA methylation in cancer
Journal of Hematology & Oncology, 2018 First identified in 1974, m6A RNA methylation, which serves as a predominant internal modification of RNA in higher eukaryotes, has gained prodigious interest in recent years. Modifications of m6A are dynamic and reversible in mammalian cells, which have
Yutian Pan +4 more
doaj +2 more sources
m6A RNA methylation promotes XIST-mediated transcriptional repression
Nature, 2016 The long non-coding RNA X-inactive specific transcript (XIST) mediates the transcriptional silencing of genes on the X chromosome. Here we show that, in human cells, XIST is highly methylated with at least 78 N6-methyladenosine (m6A) residues—a ...
Amy Chow, Deepak P Patil, Chun-Kan Chen
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m6A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment
Cell Reports, 2019 SUMMARY Stem cells balance cellular fates through asymmetric and symmetric divisions in order to self-renew or to generate downstream progenitors. Symmetric commitment divisions in stem cells are required for rapid regeneration during tissue damage and ...
Saroj Gourkanti +2 more
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m6A RNA methylation: a pivotal regulator of tumor immunity and a promising target for cancer immunotherapy. [PDF]
J Transl MedM6A modification is one of the most common regulatory mechanisms of gene expression in eukaryotic cells, influencing processes such as RNA splicing, degradation, stability, and protein translation.
Chen X +5 more
europepmc +2 more sources
m6A RNA Methylation in Cardiovascular Diseases
Molecular Therapy, 2020 Cardiovascular diseases (CVDs) remain the leading cause of death and disability worldwide, despite marked improvements in prevention, diagnosis, and early intervention.
Xiang Zhou, Shuchen Zhang, Xiaoguang Wu
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