Results 31 to 40 of about 937,277 (225)
The role m6A RNA methylation is CNS development and glioma pathogenesis
Molecular Brain, 2021 Epigenetic abnormalities play a crucial role in many tumors, including glioma. RNA methylation occurs as an epigenetic modification similar to DNA methylation and histone modification.
Ting Pan +7 more
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Frontiers in Oncology, 2021 Accumulating evidence has proven that N6-methyladenosine (m6A) RNA methylation plays an essential role in tumorigenesis. However, the significance of m6A RNA methylation modulators in the malignant progression of papillary renal cell carcinoma (PRCC) and
Lianze Chen +28 more
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LncRNAs and Chromatin Modifications Pattern m6A Methylation at the Untranslated Regions of mRNAs
Frontiers in Genetics, 2022 New roles for RNA in mediating gene expression are being discovered at an alarming rate. A broad array of pathways control patterning of N6-methyladenosine (m6A) methylation on RNA transcripts.
Lee O. Vaasjo, Lee O. Vaasjo
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Ecotoxicology and Environmental Safety, 2022 Silicosis is one of the most severe interstitial lung fibrosis diseases worldwide, caused by crystalline silica exposure. While the mechanisms and pathogenesis underlying silicosis remained unknown.
Yingdie Zhang +8 more
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The Reversible Methylation of m6A Is Involved in Plant Virus Infection
Biology, 2022 In recent years, m6A RNA methylation has attracted broad interest and is becoming a hot research topic. It has been demonstrated that there is a strong association between m6A and viral infection in the human system.
Jianying Yue, Yao Wei, Mingmin Zhao
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The functions and prognostic values of m6A RNA methylation regulators in thyroid carcinoma
Cancer Cell International, 2021 Background N6-Methyladenosine (m6A) is the most common RNA modification and regulates RNA splicing, translation, translocation, and stability. Aberrant expression of m6A has been reported in various types of human cancers.
Zhi-Hao Yu +5 more
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METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells
Nature Communications, 2021 Natural killer (NK) cells exert critical roles in anti-tumor immunity but how their functions are regulated by epitranscriptional modification (e.g., N6-methyladenosine (m6A) methylation) is unclear. Here we report decreased expression of the m6A “writer”
Hao Song +13 more
semanticscholar +1 more source
TGF-β Regulates m6A RNA Methylation after PM2.5 Exposure
, 2023 PM2.5 exposure leads to a variety of respiratory diseases, including pulmonary fibrosis, metastatic lung cancer, etc. Exposure to PM2.5 results in the alteration of epigenetic modification. M6A RNA methylation is an essential epigenetic modification that
Zhigang Li +3 more
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Frontiers in Genetics, 2021 Ovarian cancer is the most deadly gynecologic malignancy worldwide and it is warranted to dissect the critical gene regulatory network in ovarian cancer. N6-methyladenosine (m6A) RNA methylation, as the most prevalent RNA modification, is orchestrated by
Qinglv Wei +7 more
doaj +1 more source
BMC Cancer, 2020 Background Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death in the world. N6-methyladenosine (m6A) RNA methylation is dynamically regulated by m6A RNA methylation modulators (“writer,” “eraser,” and “reader” proteins)
Nanfang Qu +7 more
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