Results 51 to 60 of about 937,277 (225)

m6A RNA methylation regulates the fate of endogenous retroviruses

bioRxiv, 2020
Endogenous retroviruses (ERVs) are abundant and heterogenous groups of integrated retroviral sequences that impact genome regulation and cell physiology throughout their RNA-centered life cycle1.
Tomasz Chelmicki, Emeline Roger, Aurélie Teissandier, Sofia Rucli, François Dossin, Mathilde Dura, C. Fouassier, S. Lameiras, D. Bourc'his   +8 more
semanticscholar   +1 more source

METTL3-mediated m6A RNA methylation induces the differentiation of lung resident mesenchymal stem cells into myofibroblasts via the miR-21/PTEN pathway

Respiratory Research, 2023
Background The accumulation of myofibroblasts is the key pathological feature of pulmonary fibrosis (PF). Aberrant differentiation of lung-resident mesenchymal stem cells (LR-MSCs) has been identified as a critical source of myofibroblasts, but the ...
Yi Lu, Zeyu Liu, Yun-Jiao Zhang, Xiuhua Wu, Wei Bian, Shan Shan, Danrong Yang, Tao Ren   +7 more
semanticscholar   +1 more source

m6 RNA methylation: an emerging common target in the immune response to cancer and severe acute respiratory syndrome-coronavirus-2 infection

Exploration of Medicine, 2023
m6A RNA methylation, a predominant type of RNA modification, is involved in regulating mRNA splicing, stability, and translation as well as the interaction between nucleoproteins and noncoding RNAs.
Hiromichi Sato, Tomoaki Hara, Chihiro Otsuka, Yasuko Arao, Yoshiko Tsuji, Yumiko Hamano, Mirei Ogita, Eric di Luccio, Takaaki Hirotsu, Andrea Vecchione, Hideshi Ishii   +10 more
doaj   +1 more source

Arginine methylation in subunits of mammalian pre-mRNA cleavage factor I [PDF]

, 2010
Mammalian cleavage factor I (CF Im) is composed of two polypeptides of 25 kDa and either a 59 or 68 kDa subunit (CF Im25, CF Im59, CF Im68). It is part of the cleavage and polyadenylation complex responsible for processing the 39 ends of messenger RNA ...
Antje Ostareck-Lederer, Neuenkirchen, N., Ostareck-Lederer, Antje, Keller, W., Dettwiler, Sabine, Sabine Dettwiler, Fischer, Utz, Martin, Georges, Rüegsegger, U., Fischer, U., Georges Martin, Ashwin Chari, Blank, Diana, Diana Blank, Neuenkirchen, Nils, Blank, D., Utz Fischer, Chari, Ashwin, Ostareck-Lederer, A., Nils Neuenkirchen, Walter Keller, Chari, A., Ursula Rüegsegger, Dettwiler, S., Martin, G., Keller, Walter, Rüegsegger, Ursula   +26 more
core   +1 more source

The crosstalk between m6A RNA methylation and other epigenetic regulators: a novel perspective in epigenetic remodeling

Theranostics, 2021
Epigenetic regulation involves a range of sophisticated processes which contribute to heritable alterations in gene expression without altering DNA sequence.
Yan-Chun Zhao, Yun-Hao Chen, Mei Jin, Jin Wang   +3 more
semanticscholar   +1 more source

Malignant Evaluation and Clinical Prognostic Values of m6A RNA Methylation Regulators in Glioblastoma

Frontiers in Oncology, 2020
N6-methyladenosine (m6A) RNA methylation, the most common form of mRNA modification and regulated by the m6A RNA methylation regulators (“writers,” “erasers,” and “readers”), has been reported to be associated with the progression of the malignant tumor.
Jianyang Du, Jianyang Du, Kuiyuan Hou, Kuiyuan Hou, Shan Mi, Shan Mi, Hang Ji, Hang Ji, Shuai Ma, Shuai Ma, Yixu Ba, Yixu Ba, Shaoshan Hu, Rui Xie, Lei Chen, Lei Chen   +15 more
doaj   +1 more source

Development and Validation of an m6A RNA Methylation Regulators-Based Signature for Predicting the Prognosis of Adrenocortical Carcinoma

Frontiers in Endocrinology, 2021
BackgroundAdrenocortical carcinoma (ACC) is an aggressive and rare neoplasm that originates from the cortex of the adrenal gland. N6-methyladenosine (m6A) RNA methylation, the most common form of mRNA modification, has been reported to be correlated with
Chengquan Shen, Jing Liu, Xiaokun Yang, Wei Jiao, Yonghua Wang   +4 more
doaj   +1 more source

Regulatory mechanisms of m6A RNA methylation in esophageal cancer: a comprehensive review. [PDF]

Front Genet
Esophageal cancer is an aggressively malignant neoplasm characterized by a high mortality rate. Frequently diagnosed at an advanced stage, it presents challenges for optimal therapeutic intervention due to its non-specific symptoms, resulting in lost ...
Wen L, Fu J, Wang Z, Xie R, Tang S, Yu L, Zhou H.   +6 more
europepmc   +2 more sources

Detecting m6A methylation regions from Methylated RNA Immunoprecipitation Sequencing

Bioinformatics, 2021
AbstractMotivationThe post-transcriptional epigenetic modification on mRNA is an emerging field to study the gene regulatory mechanism and their association with diseases. Recently developed high-throughput sequencing technology named Methylated RNA Immunoprecipitation Sequencing (MeRIP-seq) enables one to profile mRNA epigenetic modification ...
Zhenxing Guo 0001, Andrew M. Shafik, Peng Jin, Zhijin Wu, Hao Wu 0003   +4 more
openaire   +2 more sources

IL-37 Confers Anti-Tumor Activity by Regulation of m6A Methylation

Frontiers in Oncology, 2021
N6-methyladenosine (m6A) is a common transcriptomic modification in cancer. Recently, it has been found to be involved in the regulation of non-small cell lung cancer (NSCLC) formation and metastasis.
Xiaofeng Mu, Xiaofeng Mu, Qi Zhao, Wen Chen, Yuxiang Zhao, Yuxiang Zhao, Qing Yan, Rui Peng, Jie Zhu, Chunrui Yang, Ketao Lan, Xiaosong Gu, Ye Wang   +12 more
doaj   +1 more source