Results 61 to 70 of about 937,277 (225)

m6A-TSHub: Unveiling the Context-specific m6A Methylation and m6A-affecting Mutations in 23 Human Tissues

, 2023
As the most pervasive epigenetic marker present on mRNAs and long non-coding RNAs (lncRNAs), N6-methyladenosine (m6A) RNA methylation has been shown to participate in essential biological processes.
Yuxin Zhang, Pedro de Magalhães, J, João Pedro de Magalhães, Rigden, DJ, Zhang, Y, Kunqi Chen, Daniel J. Rigden, Huang, D, Chen, K, Su, J, Meng, J, Song, B, Jionglong Su, Bowen Song, Zhen Wei, Daiyun Huang, Jia Meng, Wei, Z   +17 more
core   +1 more source

Role of m6A RNA methylation in cardiovascular disease (Review)

International Journal of Molecular Medicine, 2020
N6-methyladenosine (m6A) is the most prevalent and abundant type of internal post-transcriptional RNA modification in eukaryotic cells. Multiple types of RNA, including mRNAs, rRNAs, tRNAs, long non-coding RNAs and microRNAs, are involved in m6A ...
Yuhan Qin, Lin-Qing Li, E. Luo, Jian-Tong Hou, G. Yan, Dong Wang, Yong Qiao, Cheng-Chun Tang   +7 more
semanticscholar   +1 more source

Fusaric acid decreases p53 expression by altering promoter methylation and m6A RNA methylation in human hepatocellular carcinoma (HepG2) cells

, 2021
Fusaric acid (FA) is a food-borne mycotoxin that mediates toxicity with limited information on its epigenetic properties. p53 is a tumour suppressor protein that regulates cell cycle arrest and apoptotic cell death.
Terisha Ghazi, Anil A. Chuturgoon, Savania Nagiah   +2 more
core   +1 more source

m6A RNA methylation regulators contribute to malignant progression and have clinical prognostic impact in gliomas

Aging, 2019
N6-methyladenosine (m6A) RNA methylation, associated with cancer initiation and progression, is dynamically regulated by the m6A RNA methylation regulators (“writers”, “erasers” and “readers”).
R. Chai, Fan Wu, Qi-xue Wang, Shu Zhang, Ke-Nan Zhang, Yu-Qing Liu, Zheng Zhao, T. Jiang, Yong-Zhi Wang, Chun-Sheng Kang   +9 more
semanticscholar   +1 more source

The Biology of m6A RNA Methylation in Normal and Malignant Hematopoiesis [PDF]

Cancer Discovery, 2019
Abstract Hematopoietic development and differentiation are highly regulated processes, and recent studies focusing on m6A mRNA methylation have uncovered how this mark controls cell fate in both normal and malignant hematopoietic states.
Ly P, Vu, Yuanming, Cheng, Michael G, Kharas   +2 more
openaire   +2 more sources

Ibuprofen promotes p75 neurotrophin receptor expression through modifying promoter methylation and N6-methyladenosine-RNA-methylation in human gastric cancer cells

, 2022
It is acknowledged that nonsteroidal anti-inflammatory drugs (NSAIDs) can participate in various signaling pathways, while information about their epigenetic effects are limited.
Bibo Tan (11102289), Zheng Wu (344022), Zhen Liu (74646), Yuwang Bi (12961068), Zhanfei Zu (12961065), Xiaoyun Wu (179670), Xingmao Hu (12961071), Haifeng Jin (341817)   +7 more
core   +1 more source

M6A RNA Methylation Regulates Histone Ubiquitination to Support Cancer Growth and Progression

Cancer Research, 2022
Osteosarcoma is the most common malignancy of the bone, yet the survival for patients with osteosarcoma is virtually unchanged over the past 30 years. This is principally because development of new therapies is hampered by a lack of recurrent mutations ...
Pooja Yadav, P. Subbarayalu, Daisy Medina, Saif Nirzhor, Santosh Timilsina, Subapriya Rajamanickam, V. Eedunuri, Yogesh K. Gupta, Si-Yuan Zheng, Nourhan Abdelfattah, Yufei Huang, R. Vadlamudi, R. Hromas, P. Meltzer, P. Houghton, Yi-Dong Chen, M. Rao   +16 more
semanticscholar   +1 more source

Table_4_Malignant Evaluation and Clinical Prognostic Values of m6A RNA Methylation Regulators in Glioblastoma.XLSX

, 2020
N6-methyladenosine (m6A) RNA methylation, the most common form of mRNA modification and regulated by the m6A RNA methylation regulators (“writers,” “erasers,” and “readers”), has been reported to be associated with the progression of the malignant tumor.
Kuiyuan Hou (8550516), Yixu Ba (8550522), Rui Xie (826938), Shuai Ma (414625), Shaoshan Hu (795277), Jianyang Du (257357), Lei Chen (54296), Shan Mi (8550519), Hang Ji (2432434)   +8 more
core   +1 more source

Region-specific RNA m6A methylation represents a new layer of control in the gene regulatory network in the mouse brain [PDF]

Open Biology, 2017
N6-methyladenosine (m6A) is the most abundant epitranscriptomic mark found on mRNA and has important roles in various physiological processes. Despite the relatively high m6A levels in the brain, its potential functions in the brain remain largely ...
Mengqi Chang, Hongyi Lv, Weilong Zhang, Chunhui Ma, Xue He, Shunli Zhao, Zhi-Wei Zhang, Yi-Xin Zeng, Shuhui Song, Yamei Niu, Wei-Min Tong   +10 more
doaj   +1 more source

Analysis and Validation of circRNA-miRNA Network in Regulating m6A RNA Methylation Modulators Reveals CircMAP2K4/miR-139-5p/YTHDF1 Axis Involving the Proliferation of Hepatocellular Carcinoma

Frontiers in Oncology, 2021
The m6A RNA methylation modulators play a crucial role in regulating hepatocellular carcinoma (HCC) progression. The circular RNA (circRNA) regulatory network in regulating m6A RNA methylation modulators in HCC remains largely unknown.
Fanwu Chi, Yong Cao, Yuhan Chen
doaj   +1 more source