Results 11 to 20 of about 24,574 (283)
m6a RNA methylation: the implications for health and disease [PDF]
Journal of Cancer Science and Clinical Oncology, 2014 The recent resurgence of interest in m6a has been spurred by some intriguing findings detailing the effects and dynamics of this epigenetic modification.
McGuinness, D., Mcguinness, D.H.
core +4 more sources
Multiple functions of m6A RNA methylation in cancer
Journal of Hematology & Oncology, 2018 First identified in 1974, m6A RNA methylation, which serves as a predominant internal modification of RNA in higher eukaryotes, has gained prodigious interest in recent years. Modifications of m6A are dynamic and reversible in mammalian cells, which have
Yutian Pan +4 more
doaj +3 more sources
RNA m6A methylation regulators in ovarian cancer [PDF]
Cancer Cell International, 2021 AbstractN6-methyladenosine (m6A) is the most abundant RNA modification of mammalian mRNAs and plays a vital role in many diseases, especially tumours. In recent years, m6A has become the topic of intense discussion in epigenetics. M6A modification is dynamically regulated by methyltransferases, demethylases and RNA-binding proteins. Ovarian cancer (OC)
Jialu Guo +3 more
openaire +3 more sources
Juvenile hormone regulates silk gene expression by m6A RNA methylation [PDF]
Cellular and Molecular Life Sciences, 2023 Abstract Juvenile hormone (JH) is an indispensable insect hormone that is critical in regulating insect development and physiology. N6-methyladenosine (m6A) is the most abundant modification of RNA that regulates RNA fate in eukaryotic organisms. However, the relationship between m6A and JH remains largely unknown.
Shuai‐Qi Liu +3 more
openalex +3 more sources
m6A RNA Methylation in Cardiovascular Diseases [PDF]
Molecular Therapy, 2020 Cardiovascular diseases (CVDs) remain the leading cause of death and disability worldwide, despite marked improvements in prevention, diagnosis, and early intervention. There is an urgent need to discover more effective therapeutic strategies, which would be facilitated by a more in-depth understanding of CVDs and their underlying molecular mechanisms.
Siyi, Wu +3 more
openaire +2 more sources
RNA m6A methylation across the transcriptome
Molecular Cell, 2023 Since the early days of foundational studies of nucleic acids, many chemical moieties have been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one of these chemical modifications, N6-methyl adenosine (m6A), is unique in a way that it is highly abundant not only on RNA polymerase II (RNAPII) transcribed, protein-coding ...
Erdem, Sendinc, Yang, Shi
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The role of m6A RNA methylation regulator in meningioma. [PDF]
Aging (Albany NY), 2023 Meningiomas are common intracranial tumors, and the effect of surgical resection is often unsatisfactory. N6-Methyladenosine (m6A)-related regulator expression levels are related to cancer occurrence and development. This study aimed to investigate the roles of m6A RNA methylation regulators in meningiomas, as these are currently unclear.
Yang Y, Luo L, Zhou Z.
europepmc +3 more sources
Expression and prognostic significance of the m6A RNA methylation regulator HNRNPC in HNSCC [PDF]
Front OncolZhang Y +10 more
europepmc +3 more sources
IET Systems Biology, 2022 N6‐methyladenosine (m6A) RNA methylation is correlated with carcinogenesis and dynamically possessed through the m6A RNA methylation regulators. This paper aimed to explore 13 m6A RNA methylation regulators' role in gastrointestinal cancer (GIC) and ...
Yandong Miao +6 more
doaj +1 more source
Frontiers in Pharmacology, 2022 N6-methyladenosine (m6A) RNA methylation has been considered the most prevalent, abundant, and conserved internal transcriptional modification throughout the eukaryotic mRNAs.
Zhaolin Chen +7 more
doaj +1 more source