Results 31 to 40 of about 24,574 (283)

The Reversible Methylation of m6A Is Involved in Plant Virus Infection

Biology, 2022
In recent years, m6A RNA methylation has attracted broad interest and is becoming a hot research topic. It has been demonstrated that there is a strong association between m6A and viral infection in the human system.
Jianying Yue, Yao Wei, Mingmin Zhao
doaj   +1 more source

The Biogenesis and Precise Control of RNA m6A Methylation [PDF]

Trends in Genetics, 2020
N6-Methyladenosine (m6A) is the most prevalent internal RNA modification in mRNA, and has been found to be highly conserved and hard-coded in mammals and other eukaryotic species. The importance of m6A for gene expression regulation and cell fate decisions has been well acknowledged in the past few years.
Huilin, Huang, Hengyou, Weng, Jianjun, Chen   +2 more
openaire   +2 more sources

Effects of m6A RNA methylation regulators on endometrial cancer [PDF]

Journal of Clinical Laboratory Analysis, 2021
AbstractBackgroundThe modification 6‐methyladenine (m6A) is the most common type in RNA methylation. Our study aims to explore the bioinformatic analysis of m6A in endometrial cancer.MethodsThe expression of 23 m6A RNA methylation regulators was compared through The Cancer Genome Atlas (TCGA) database among 406 endometrial tissue and 19 normal tissue ...
Yanli Zhang, Yingjie Yang
openaire   +2 more sources

Exploration of the Role of m6 A RNA Methylation Regulators in Malignant Progression and Clinical Prognosis of Ovarian Cancer

Frontiers in Genetics, 2021
Ovarian cancer is the most deadly gynecologic malignancy worldwide and it is warranted to dissect the critical gene regulatory network in ovarian cancer. N6-methyladenosine (m6A) RNA methylation, as the most prevalent RNA modification, is orchestrated by
Qinglv Wei, Dan Yang, Xiaoyi Liu, Hongyan Zhao, Yu Yang, Jing Xu, Tao Liu, Ping Yi   +7 more
doaj   +1 more source

The m6A-related gene signature for predicting the prognosis of breast cancer [PDF]

PeerJ, 2021
N6-methyladenosine (m6A) modification has been shown to participate in tumorigenesis and metastasis of human cancers. The present study aimed to investigate the roles of m6A RNA methylation regulators in breast cancer.
Shanliang Zhong, Zhenzhong Lin, Huanwen Chen, Ling Mao, Jifeng Feng, Siying Zhou   +5 more
doaj   +2 more sources

Functional organization of box C/D RNA-guided RNA methyltransferase [PDF]

, 2020
Box C/D RNA protein complexes (RNPs) catalyze site-specific 2'-O-methylation of RNA with specificity determined by guide RNAs. In eukaryotic C/D RNP, the paralogous Nop58 and Nop56 proteins specifically associate with terminal C/D and internal C'/D ...
Huang, Lin, Lilley, David M. J., Wang, Jiayin, Yang, Zuxiao, Ye, Keqiong   +4 more
core   +2 more sources

m6A RNA methylation regulates the fate of endogenous retroviruses

Nature, 2021
Endogenous retroviruses (ERVs) are abundant and heterogenous groups of integrated retroviral sequences that affect genome regulation and cell physiology throughout their RNA-centred life cycle1. Failure to repress ERVs is associated with cancer, infertility, senescence and neurodegenerative diseases2,3.
Chelmicki, Tomasz, Roger, Emeline, Teissandier, Aurélie, Dura, Mathilde, Bonneville, Lorraine, Rucli, Sofia, Dossin, François, Fouassier, Camille, Lameiras, Sonia, Bourc’his, Deborah   +9 more
openaire   +2 more sources

m6A RNA methylation regulates mitochondrial function. [PDF]

Hum Mol Genet
Abstract RNA methylation of N6-methyladenosine (m6A) is emerging as a fundamental regulator of every aspect of RNA biology. RNA methylation directly impacts protein production to achieve quick modulation of dynamic biological processes. However, whether RNA methylation regulates mitochondrial function is not known, especially in neuronal
Kahl M, Xu Z, Arumugam S, Edens B, Fischietti M, Zhu AC, Platanias LC, He C, Zhuang X, Ma YC.   +9 more
europepmc   +3 more sources

Multiple m6A RNA methylation modulators promote the malignant progression of hepatocellular carcinoma and affect its clinical prognosis

BMC Cancer, 2020
Background Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death in the world. N6-methyladenosine (m6A) RNA methylation is dynamically regulated by m6A RNA methylation modulators (“writer,” “eraser,” and “reader” proteins)
Nanfang Qu, Sanyu Qin, Xuemei Zhang, Xiaotong Bo, Zhengchun Liu, Chao Tan, Guiqiong Wen, Haixing Jiang   +7 more
doaj   +1 more source

Interaction between m6A methylation and noncoding RNA in glioma

Cell Death Discovery, 2022
AbstractGlioma is considered to be the most common brain malignancy in the central nervous system. At present, the aetiology of glioma is not clear. Due to its rapidly growth and easily recurrence, the prognosis of patients with glioma is very poor.
Nairong Tao, Tongxuan Wen, Tong Li, Lan Luan, Hai Pan, Yong Wang   +5 more
openaire   +3 more sources