Results 51 to 60 of about 24,574 (283)
The role of m6A RNA methylation in cancer
Biomedicine & Pharmacotherapy, 2019 N6-methyladenosine (m6A), the most abundant internal modification of RNA in eukaryotic cells, has gained increasing attention in recent years. The m6A modification affects multiple aspects of RNA metabolism, ranging from RNA processing, nuclear export, RNA translation to decay.
Ting, Sun, Ruiyan, Wu, Liang, Ming
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Current epigenetic aspects the clinical kidney researcher should embrace [PDF]
, 2017 Chronic kidney disease (CKD), affecting 10-12% of the world's adult population, is associated with a considerably elevated risk of serious comorbidities, in particular, premature vascular disease and death.
Ekström, Tomas J. +5 more
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RNA m6A Methylation Regulators Multi-Omics Analysis in Prostate Cancer [PDF]
Frontiers in Genetics, 2021 RNA N6-methyladenosine (m6A) methylation is known to be the most popular RNA modification in animals. Many research reports have elaborated on the effects of m6A regulators in medical practice, such as diagnosis, prognosis, and treatment. M6A modification has evident impacts on many aspects of RNA metabolism, just like RNA splicing, processing ...
Hao Su, Yutao Wang, Hongjun Li
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Frontiers in Oncology, 2020 N6-methyladenosine (m6A) RNA methylation, the most common form of mRNA modification and regulated by the m6A RNA methylation regulators (“writers,” “erasers,” and “readers”), has been reported to be associated with the progression of the malignant tumor.
Jianyang Du +15 more
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Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation [PDF]
, 2017 Transcription and translation are two main pillars of gene expression. Due to the different timings, spots of action, and mechanisms of regulation, these processes are mainly regarded as distinct and generally uncoupled, despite serving a common purpose.
Agami, R. (Reuven) +6 more
core +4 more sources
Frontiers in Endocrinology, 2021 BackgroundAdrenocortical carcinoma (ACC) is an aggressive and rare neoplasm that originates from the cortex of the adrenal gland. N6-methyladenosine (m6A) RNA methylation, the most common form of mRNA modification, has been reported to be correlated with
Chengquan Shen +4 more
doaj +1 more source
m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination [PDF]
, 2016 N6-methyladenosine (m6A) is the most common internal modification of eukaryotic messenger RNA (mRNA) and is decoded by YTH domain proteins1, 2, 3, 4, 5, 6, 7.
A Hilfiker +48 more
core +5 more sources
Frontiers in Oncology, 2021 The m6A RNA methylation modulators play a crucial role in regulating hepatocellular carcinoma (HCC) progression. The circular RNA (circRNA) regulatory network in regulating m6A RNA methylation modulators in HCC remains largely unknown.
Fanwu Chi, Yong Cao, Yuhan Chen
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Role of non-coding RNAs in the transgenerational epigenetic transmission of the effects of reprotoxicants [PDF]
, 2016 13 p.-1 fig.Non-coding RNAs (ncRNAs) are regulatory elements of gene expression and chromatin structure. Both long and small ncRNAs can also act as inductors and targets of epigenetic programs.
Del Mazo, Jesús, Larriba, E.
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Region-specific RNA m6A methylation represents a new layer of control in the gene regulatory network in the mouse brain [PDF]
Open Biology, 2017 N6-methyladenosine (m6A) is the most abundant epitranscriptomic mark found on mRNA and has important roles in various physiological processes. Despite the relatively high m6A levels in the brain, its potential functions in the brain remain largely ...
Mengqi Chang +10 more
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