Results 11 to 20 of about 1,703 (147)

Tuning the binding interface between Machupo virus glycoprotein and human transferrin receptor [PDF]

Proteins: Structure, Function and Bioinformatics, 2021
Abstract Machupo virus, known to cause hemorrhagic fevers, enters human cells via binding with its envelope glycoprotein to transferrin receptor 1 (TfR). Similarly, the receptor interactions have been explored in biotechnological applications as a molecular system to ferry therapeutics across the cellular membranes and through the impenetrable blood ...
Anneli Lundgren, Scott J Garforth, Siniša Bjelic   +2 more
exaly   +9 more sources

Analyzing machupo virus-receptor binding by molecular dynamics simulations [PDF]

PeerJ, 2014
In many biological applications, we would like to be able to computationally predict mutational effects on affinity in protein–protein interactions. However, many commonly used methods to predict these effects perform poorly in important test cases.
Austin G. Meyer, Sara L. Sawyer, Andrew D. Ellington, Claus O. Wilke   +3 more
doaj   +11 more sources

Machupo virus glycoprotein determinants for human transferrin receptor 1 binding and cell entry. [PDF]

PLoS ONE, 2011
Machupo virus (MACV) is a highly pathogenic New World arenavirus that causes hemorrhagic fever in humans. MACV, as well as other pathogenic New World arenaviruses, enter cells after their GP1 attachment glycoprotein binds to their cellular receptor ...
Sheli R Radoshitzky, Lindsay E Longobardi, Jens H Kuhn, Cary Retterer, Lian Dong, Jeremiah C Clester, Krishna Kota, John Carra, Sina Bavari   +8 more
doaj   +8 more sources

Structure of Machupo virus polymerase in complex with matrix protein Z [PDF]

Nature Communications, 2021
The RNA polymerase L of arenaviruses is of interest for drug design and its activity is inhibited by the matrix protein Z. Here, the authors present the cryo-EM structure of the Machupo virus polymerase L in complex with matrix protein Z and discuss the ...
Jun Ma, Shuangyue Zhang, Xinzheng Zhang
doaj   +6 more sources

Immunoinformatics Approach to Design Multi-Epitope-Based Vaccine against Machupo Virus Taking Viral Nucleocapsid as a Potential Candidate [PDF]

Vaccines, 2022
The family members of Arenaviridae include members of the genus Machupo virus, which have bi-segmented negative sense RNA inside the envelope and can be transferred to humans through rodent carriers.
Muhammad Naveed, Syeda Izma Makhdoom, Urooj Ali, Khizra Jabeen, Tariq Aziz, Ayaz Ali Khan, Sumbal Jamil, Muhammad Shahzad, Metab Alharbi, Abdulrahman Alshammari   +9 more
doaj   +6 more sources

Characterization of a STAT-1 Knockout Mouse Model for Machupo Virus Infection and Pathogenesis [PDF]

Viruses
Machupo virus (MACV), a member of the Arenaviridae family and causative agent of Bolivian hemorrhagic fever, results in lethality rates of 25–35% in humans.
Stephanie R. Monticelli, Ana I. Kuehne, Russell R. Bakken, Susan R. Coyne, Kenise D. Lewis, Jo Lynne W. Raymond, Xiankun Zeng, Joshua B. Richardson, Zebulon Lapoint, Jennifer L. Williams, Christopher P. Stefan, Jeffrey R. Kugelman, Jeffrey W. Koehler, Andrew S. Herbert   +13 more
doaj   +5 more sources

A STAT-1 knockout mouse model for Machupo virus pathogenesis [PDF]

Virology Journal, 2011
Background Machupo virus (MACV), a member of the Arenaviridae, causes Bolivian hemorrhagic fever, with ~20% lethality in humans. The pathogenesis of MACV infection is poorly understood, and there are no clinically proven treatments for disease.
Shurtleff Amy C, Stuthman Kelly S, Bradfute Steven B, Bavari Sina   +3 more
doaj   +7 more sources

Monoclonal Antibodies with Neutralizing Activity and Fc-Effector Functions against the Machupo Virus Glycoprotein [PDF]

Journal of Virology, 2020
MACV infections are a significant public health concern and lead to high case fatality rates. No specific treatment or vaccine for MACV infections exist. However, cases of Junin virus infection, a related virus, can be treated with convalescent-phase serum. This indicates that a MAb-based therapy for MACV could be effective.
Fatima Amanat, James Duehr, Cheng Huang   +2 more
exaly   +7 more sources

Glycoprotein-Specific Polyclonal Antibodies Targeting Machupo Virus Protect Guinea Pigs against Lethal Infection [PDF]

Vaccines
Convalescent plasma has been shown to be effective at protecting humans against severe diseases caused by New World (NW) arenaviruses, including Junin virus (JUNV) and Machupo virus (MACV).
Joseph W. Golden, Steven A. Kwilas, Jay W. Hooper   +2 more
doaj   +6 more sources

Drug discovery technologies and strategies for Machupo virus and other New World arenaviruses [PDF]

Expert Opinion on Drug Discovery, 2012
Seven arenaviruses cause viral hemorrhagic fever in humans: the Old World arenaviruses Lassa and Lujo, and the New World Clade B arenaviruses Machupo (MACV), Junín (JUNV), Guanarito (GTOV), Sabiá (SABV), and Chapare (CHPV). All of these viruses are Risk Group 4 biosafety pathogens. MACV causes human disease outbreak with high case-fatality rates.
Sheli R Radoshitzky, , Peter B Jahrling
exaly   +7 more sources