Results 21 to 30 of about 1,040,510 (176)

A hTfR1 Receptor-Specific VHH Antibody Neutralizes Pseudoviruses Expressing Glycoproteins from Junín and Machupo Viruses [PDF]

Viruses
The Junín virus (JUNV) is one of the New World arenaviruses that cause severe hemorrhagic fever. Human transferrin receptor 1 (hTfR1) has been identified as the main receptor for JUNV for virus entry into host cells.
Qinglin Kang, Gege Li, Yan Wu, Shaoyan Wang, Zhengshan Chen, Xiaodong Zai, Xiaoyan Pan, Rong Wang, Jiansheng Lu, Peng Du, Zhixin Yang, Xiangyang Chi, Gengfu Xiao, Junjie Xu   +13 more
doaj   +2 more sources

High throughput screening for SARS-CoV-2 inhibitors targeting 5 helix bundle [PDF]

SLAS Discovery
SARS-CoV-2 and other related viruses enter host cells via receptor recognition and membrane fusion. A crucial part of this is mediated by 5HB which is capable of binding to the viral spike heptad repeats (HR2) making 5HB a potential druggable target of ...
Emery Smith, Qibin Geng, Justin Shumate, Yuka Otsuka, Louis Scampavia, Thomas D. Bannister, Timothy P. Spicer   +6 more
doaj   +2 more sources

Inhibitors of the Machupo Virus L Endonuclease for Bolivian Hemorrhagic Fever Treatments

Microorganisms
Machupo virus (MACV) is the causal agent of Bolivian Hemorrhagic fever. It is highly pathogenic, has a high mortality rate, and currently lacks specific treatments or vaccines. MACV belongs to the Arenaviridae family, which uses a cap-snatching mechanism
Oluwafoyinsola O. Faniyi, Kristin V. Lyles, Neva Agarwala, Haozhe Cheng, Elise Copeland, Teri Tran, Shuyue Yang, Bingchen Yu, Binghe Wang, Xiaoxiao Yang, Ming Luo   +10 more
doaj   +2 more sources

The History of Machupo Virus in Bolivia: Arenavirus Hemorrhagic Fever

, 2018
Yambuku is what the Africans called the Ebola virus that struck hundreds of victims in Sub-Sahara Africa in 1993 and received so much notoriety in the American news media. What most people do not know is that an outbreak of a "sister" virus to Ebola occurred in a small community in the Amazon Basin in Bolivia about one year later. Similar to its deadly
Tiffany Y. Strauchs (5460290)
openaire   +2 more sources

Assembly of a functional Machupo virus polymerase complex. [PDF]

Proc Natl Acad Sci U S A, 2010
Segmented negative-sense viruses of the family Arenaviridae encode a large polymerase (L) protein that contains all of the enzymatic activities required for RNA synthesis. These activities include an RNA-dependent RNA polymerase (RdRP) and an RNA endonuclease that cleaves capped primers from ...
Kranzusch PJ, Schenk AD, Rahmeh AA, Radoshitzky SR, Bavari S, Walz T, Whelan SP.   +6 more
europepmc   +6 more sources

RNA ligands activate the Machupo virus polymerase and guide promoter usage. [PDF]

Proc Natl Acad Sci U S A, 2019
Significance Atomic structures of the polymerase–endonuclease complex of the orthomyxovirus influenza and the orthobunyavirus La Crosse—two distinct segmented negative-sense (SNS) RNA viruses—demonstrate that binding of the genomic 5′ RNA rearranges the catalytic residues of the RNA-dependent RNA-polymerase (RdRP).
Pyle JD, Whelan SPJ.
europepmc   +3 more sources

Unusual molecular architecture of the machupo virus attachment glycoprotein. [PDF]

J Virol, 2009
ABSTRACTNew World arenaviruses, which cause severe hemorrhagic fever, rely upon their envelope glycoproteins for attachment and fusion into their host cell. Here we present the crystal structure of the Machupo virus GP1 attachment glycoprotein, which is responsible for high-affinity binding at the cell surface to the transferrin receptor.
Bowden TA, Crispin M, Graham SC, Harvey DJ, Grimes JM, Jones EY, Stuart DI.   +6 more
europepmc   +5 more sources

Validation of Сhoice of Laboratory Model for Preclinical Estimation of Medical Protectors Against Bolivian Hemorrhagic Fever

Вестник войск РХБ защиты, 2023
This review is dedicated to the peculiarities of pathogenesis of the experimental Bolivian hemorrhagic fever (BHF) - the disease, caused by Machupo virus (Arenaviridae family).
T. E. Sizikova, V. N. Lebedev, V. B. Pantukhov, E. Y. Vakhnov, S. V. Borisevich   +4 more
doaj   +1 more source

Understanding machupo virus: A neglected arenavirus with global health importance. [PDF]

World J Virol
Machupo virus (MACV), classified within the Mammarenavirus genus of the Arenaviridae family, serves as the causative agent of Bolivian hemorrhagic fever (BHF), a life-threatening zoonosis primarily confined to rural regions of Bolivia’s Beni Department.
Uppala PK, Karanam SK, Kandra NV, Edhi S.   +3 more
europepmc   +2 more sources

A substitution in the transmembrane region of the glycoprotein leads to an unstable attenuation of Machupo virus. [PDF]

J Virol, 2014
ABSTRACT Machupo virus (MACV) is the etiologic agent of Bolivian hemorrhagic fever (BHF). Utilizing a reverse-genetics system recently developed, we report the rescue of a rationally modified recombinant MACV containing a single mutation in the transmembrane region of the glycoprotein.
Patterson M, Koma T, Seregin A, Huang C, Miller M, Smith J, Yun N, Smith J, Paessler S.   +8 more
europepmc   +4 more sources