Results 21 to 30 of about 2,664 (183)

Isolation of Reconstructed Functional Ribonucleoprotein Complexes of Machupo Virus. [PDF]

J Virol, 2021
Arenaviruses are rodent-borne pathogens that can cause severe disease in humans. All arenaviruses begin the infection cycle with delivery of the virus replication machinery into the cytoplasm of the host cell.
Pyle JD, Whelan SPJ.
europepmc   +4 more sources

A review of emerging health threats from zoonotic New World mammarenaviruses [PDF]

BMC Microbiology
Despite repeated spillover transmission and their potential to cause significant morbidity and mortality in human hosts, the New World mammarenaviruses remain largely understudied.
Arianna Lendino, Adrian A. Castellanos, David M. Pigott, Barbara A. Han   +3 more
doaj   +2 more sources

Structure and stabilization of the antigenic glycoprotein building blocks of the New World mammarenavirus spike complex [PDF]

mBio
The spillover of New World (NW) arenaviruses from rodent reservoirs into human populations poses a continued risk to human health. NW arenaviruses present a glycoprotein (GP) complex on the envelope surface of the virion, which orchestrates host cell ...
Guido C. Paesen, Weng M. Ng, Simon Kimuda, Geoff Sutton, Katie J. Doores, Thomas A. Bowden   +5 more
doaj   +2 more sources

RNA ligands activate the Machupo virus polymerase and guide promoter usage. [PDF]

Proc Natl Acad Sci U S A, 2019
Significance Atomic structures of the polymerase–endonuclease complex of the orthomyxovirus influenza and the orthobunyavirus La Crosse—two distinct segmented negative-sense (SNS) RNA viruses—demonstrate that binding of the genomic 5′ RNA rearranges the catalytic residues of the RNA-dependent RNA-polymerase (RdRP). Working with the arenavirus,
Pyle JD, Whelan SPJ.
europepmc   +3 more sources

Assembly of a functional Machupo virus polymerase complex. [PDF]

Proc Natl Acad Sci U S A, 2010
Segmented negative-sense viruses of the family Arenaviridae encode a large polymerase (L) protein that contains all of the enzymatic activities required for RNA synthesis. These activities include an RNA-dependent RNA polymerase (RdRP) and an RNA endonuclease that cleaves capped primers from ...
Kranzusch PJ, Schenk AD, Rahmeh AA, Radoshitzky SR, Bavari S, Walz T, Whelan SP.   +6 more
europepmc   +5 more sources

Validation of Сhoice of Laboratory Model for Preclinical Estimation of Medical Protectors Against Bolivian Hemorrhagic Fever

Вестник войск РХБ защиты, 2023
This review is dedicated to the peculiarities of pathogenesis of the experimental Bolivian hemorrhagic fever (BHF) - the disease, caused by Machupo virus (Arenaviridae family).
T. E. Sizikova, V. N. Lebedev, V. B. Pantukhov, E. Y. Vakhnov, S. V. Borisevich   +4 more
doaj   +1 more source

Ribonucleoprotein transport in Negative Strand RNA viruses

Biology of the Cell, Volume 115, Issue 1, January 2023., 2023
The genome replication of Negative‐sense, single‐stranded RNA viruses most‐often segregate in membrane‐less environments called inclusion bodies (IBs). These “organelles” usually locate far from the cell surface from where new virions are released. Here, for each viral family, we discuss how the genome progeny is transported from the IBs to reach the ...
Cédric Diot, Gina Cosentino, Marie‐Anne Rameix‐Welti   +2 more
wiley   +1 more source

Chapare virus, a newly discovered arenavirus isolated from a fatal hemorrhagic fever case in Bolivia. [PDF]

PLoS Pathogens, 2008
A small focus of hemorrhagic fever (HF) cases occurred near Cochabamba, Bolivia, in December 2003 and January 2004. Specimens were available from only one fatal case, which had a clinical course that included fever, headache, arthralgia, myalgia, and ...
Simon Delgado, Bobbie R Erickson, Roberto Agudo, Patrick J Blair, Efrain Vallejo, César G Albariño, Jorge Vargas, James A Comer, Pierre E Rollin, Thomas G Ksiazek, James G Olson, Stuart T Nichol   +11 more
doaj   +1 more source

Recruitment of dynein and kinesin to viral particles

The FASEB Journal, Volume 36, Issue 5, May 2022., 2022
Abstract Dynein and kinesin are cytoskeletal motor proteins involved in transporting cellular cargos and viruses. Throughout viral infection, they actively participate in the virus life cycle in the cell during entry, genome replication, and departure.
Sayi’Mone Tati, Laleh Alisaraie
wiley   +1 more source

Observation of arenavirus nucleoprotein heptamer assembly

FEBS Open Bio, Volume 11, Issue 4, Page 1076-1083, April 2021., 2021
The nucleoprotein associates with RNA to form a ribonucleoprotein complex. The nucleoprotein trends to self‐assemble into heptameric rings. Theses rings represent stable intermediate states representative of the average full turn of the Arenaviridae ribonucleoprotein filament.
Nicolas Papageorgiou, Afroditi Vaitsopoulou, Awa Diop, Thi Hong Van Nguyen, Bruno Canard, Karine Alvarez, François Ferron   +6 more
wiley   +1 more source