Description and characterization of a novel live-attenuated tri-segmented Machupo virus in Guinea pigs [PDF]
Virology Journal, 2018 Background Machupo virus (MACV) is a member of the Mammarenavirus genus, Arenaviridae family and is the etiologic agent of Bolivian hemorrhagic fever, which causes small outbreaks or sporadic cases. Several other arenaviruses in South America Junín virus
Amélie D. Zaza +2 more
doaj +6 more sources
Comparison of Vaccine Platforms for Machupo Virus [PDF]
VaccinesBackground/Objectives: Pathogenic mammarenaviruses cause severe hemorrhagic and neurologic disease in humans. Machupo virus (MACV), a New World (NW) mammarenavirus, causes Bolivian hemorrhagic fever in humans, and there are no approved vaccines. Methods:
Rachel Erickson +6 more
doaj +3 more sources
Unusual molecular architecture of the machupo virus attachment glycoprotein. [PDF]
J Virol, 2009 ABSTRACTNew World arenaviruses, which cause severe hemorrhagic fever, rely upon their envelope glycoproteins for attachment and fusion into their host cell. Here we present the crystal structure of the Machupo virus GP1 attachment glycoprotein, which is responsible for high-affinity binding at the cell surface to the transferrin receptor.
Bowden TA +6 more
europepmc +7 more sources
Isothermal real-time RT-RPA for Machupo virus detection: Field-adaptable sensitivity comparable with laboratory PCR. [PDF]
PLoS ONEIsothermal nucleic acid amplification methods, such as recombinase polymerase amplification (RPA), are becoming increasingly vital as diagnostic platforms for neglected tropical diseases by enabling rapid and accurate detection in under-resourced regions.
Marina A Kapitonova +5 more
doaj +5 more sources
The Ectodomain of Glycoprotein from the Candid#1 Vaccine Strain of Junin Virus Rendered Machupo Virus Partially Attenuated in Mice Lacking IFN-αβ/γ Receptor. [PDF]
PLoS Neglected Tropical Diseases, 2016 Machupo virus (MACV), a New World arenavirus, is the etiological agent of Bolivian hemorrhagic fever (BHF). Junin virus (JUNV), a close relative, causes Argentine hemorrhagic fever (AHF).
Takaaki Koma +7 more
doaj +4 more sources
RNA ligands activate the Machupo virus polymerase and guide promoter usage. [PDF]
Proc Natl Acad Sci U S A, 2019 Significance Atomic structures of the polymerase–endonuclease complex of the orthomyxovirus influenza and the orthobunyavirus La Crosse—two distinct segmented negative-sense (SNS) RNA viruses—demonstrate that binding of the genomic 5′ RNA rearranges the catalytic residues of the RNA-dependent RNA-polymerase (RdRP). Working with the arenavirus,
Pyle JD, Whelan SPJ.
europepmc +5 more sources
Simultaneous screening for selective SARS-CoV-2, Lassa, and Machupo virus entry inhibitors [PDF]
SLAS DiscoveryEmerging highly pathogenic viruses can pose profound impacts on global health, the economy, and society. To meet that challenge, the National Institute of Allergy and Infectious Diseases (NIAID) established nine Antiviral Drug Discovery (AViDD) centers ...
Yuka Otsuka +9 more
doaj +4 more sources
Assembly of a functional Machupo virus polymerase complex. [PDF]
Proc Natl Acad Sci U S A, 2010 Segmented negative-sense viruses of the family Arenaviridae encode a large polymerase (L) protein that contains all of the enzymatic activities required for RNA synthesis. These activities include an RNA-dependent RNA polymerase (RdRP) and an RNA endonuclease that cleaves capped primers from ...
Kranzusch PJ +6 more
europepmc +7 more sources
A hTfR1 Receptor-Specific VHH Antibody Neutralizes Pseudoviruses Expressing Glycoproteins from Junín and Machupo Viruses [PDF]
VirusesThe Junín virus (JUNV) is one of the New World arenaviruses that cause severe hemorrhagic fever. Human transferrin receptor 1 (hTfR1) has been identified as the main receptor for JUNV for virus entry into host cells.
Qinglin Kang +13 more
doaj +4 more sources
Machupo Virus Expressing GPC of the Candid#1 Vaccine Strain of Junin Virus Is Highly Attenuated and Immunogenic. [PDF]
J Virol, 2016 ABSTRACT Machupo virus (MACV) is the causative agent of Bolivian hemorrhagic fever. Our previous study demonstrated that a MACV strain with a single amino acid substitution (F438I) in the transmembrane domain of glycoprotein is attenuated but genetically unstable in mice.
Koma T +9 more
europepmc +6 more sources